probucol-3223 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the probucol-3223 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain
ACE2 angiotensin I converting enzyme 2
ACO2 aconitase 2, mitochondrial
ALDOB aldolase B, fructose-bisphosphate
ALOX5 arachidonate 5-lipoxygenase
ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
ATP6V1C1 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1
ATPAF2 ATP synthase mitochondrial F1 complex assembly factor 2
ATXN2L ataxin 2-like
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2
CCL27 chemokine (C-C motif) ligand 27
CCPG1 cell cycle progression 1
CD58 CD58 molecule
CDC25A cell division cycle 25A
CDC25C cell division cycle 25C
CFHR4 complement factor H-related 4
CFLAR CASP8 and FADD-like apoptosis regulator
CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle)
CNOT3 CCR4-NOT transcription complex, subunit 3
COL13A1 collagen, type XIII, alpha 1
CXCR4 chemokine (C-X-C motif) receptor 4
CYHR1 cysteine/histidine-rich 1
DIO2 deiodinase, iodothyronine, type II
EFNA3 ephrin-A3
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1
FAM76A family with sequence similarity 76, member A
FCAR Fc fragment of IgA receptor
FHL1 four and a half LIM domains 1
GAS7 growth arrest-specific 7
GEMIN7 gem (nuclear organelle) associated protein 7
GNAT2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2
GNG13 guanine nucleotide binding protein (G protein), gamma 13
GPR85 G protein-coupled receptor 85
HES2 hes family bHLH transcription factor 2
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
ICA1 islet cell autoantigen 1, 69kDa
IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker)
IGL immunoglobulin lambda locus
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5
KIF2A kinesin heavy chain member 2A
LIG3 ligase III, DNA, ATP-dependent
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3
MATN3 matrilin 3
METTL7A methyltransferase like 7A
MFAP3L microfibrillar-associated protein 3-like
MIA melanoma inhibitory activity
MPP1 membrane protein, palmitoylated 1, 55kDa
NCF4 neutrophil cytosolic factor 4, 40kDa
NCOR2 nuclear receptor corepressor 2
NDRG2 NDRG family member 2
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NFIB nuclear factor I/B
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NRTN neurturin
NUP88 nucleoporin 88kDa
OCLM oculomedin
OPRL1 opiate receptor-like 1
ORAI2 ORAI calcium release-activated calcium modulator 2
PCDH1 protocadherin 1
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PITX1 paired-like homeodomain 1
PLAC4 placenta-specific 4
PLK3 polo-like kinase 3
PLXNB1 plexin B1
POU2F2 POU class 2 homeobox 2
PPP1R14D protein phosphatase 1, regulatory (inhibitor) subunit 14D
PPP5C protein phosphatase 5, catalytic subunit
PRB1 proline-rich protein BstNI subfamily 1
RNF125 ring finger protein 125, E3 ubiquitin protein ligase
RPL23AP32 ribosomal protein L23a pseudogene 32
RQCD1 RCD1 required for cell differentiation1 homolog (S. pombe)
SAPCD1 suppressor APC domain containing 1
SCRT1 scratch family zinc finger 1
SEMA6B sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B
SFTPB surfactant protein B
SH3BP2 SH3-domain binding protein 2
SIRT5 sirtuin 5
SLMO1 slowmo homolog 1 (Drosophila)
SOCS3 suppressor of cytokine signaling 3
SORT1 sortilin 1
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
SPON2 spondin 2, extracellular matrix protein
TBL1Y transducin (beta)-like 1, Y-linked
TCP11L1 t-complex 11, testis-specific-like 1
TLK1 tousled-like kinase 1
TMOD1 tropomodulin 1
TP53AIP1 tumor protein p53 regulated apoptosis inducing protein 1
TRIM3 tripartite motif containing 3
UBXN1 UBX domain protein 1
UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15
UHRF1BP1L UHRF1 binding protein 1-like
ZFP36L1 ZFP36 ring finger protein-like 1
ZSCAN2 zinc finger and SCAN domain containing 2
ZSWIM1 zinc finger, SWIM-type containing 1

decreased expression

Symbol Name
ABHD14A abhydrolase domain containing 14A
AKR1C2 aldo-keto reductase family 1, member C2
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle)
ANKRD40 ankyrin repeat domain 40
ARHGAP4 Rho GTPase activating protein 4
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARID3B AT rich interactive domain 3B (BRIGHT-like)
ARRB1 arrestin, beta 1
ART1 ADP-ribosyltransferase 1
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
BAHCC1 BAH domain and coiled-coil containing 1
BTF3P11 basic transcription factor 3 pseudogene 11
C14ORF105 chromosome 14 open reading frame 105
C14ORF132 chromosome 14 open reading frame 132
C22ORF46 chromosome 22 open reading frame 46
C8ORF60 chromosome 8 open reading frame 60
CARD8 caspase recruitment domain family, member 8
CCDC85C coiled-coil domain containing 85C
CDADC1 cytidine and dCMP deaminase domain containing 1
CES1 carboxylesterase 1
CFAP69 cilia and flagella associated protein 69
CIC capicua transcriptional repressor
CIDEB cell death-inducing DFFA-like effector b
CLSPN claspin
CORO7 coronin 7
CRIP1 cysteine-rich protein 1 (intestinal)
CRY2 cryptochrome circadian clock 2
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
DEAF1 DEAF1 transcription factor
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DUSP13 dual specificity phosphatase 13
DYSF dysferlin
DZANK1 double zinc ribbon and ankyrin repeat domains 1
EAF2 ELL associated factor 2
FAAH fatty acid amide hydrolase
FADS2 fatty acid desaturase 2
FKBP10 FK506 binding protein 10, 65 kDa
FLT4 fms-related tyrosine kinase 4
GEMIN8 gem (nuclear organelle) associated protein 8
GIF gastric intrinsic factor (vitamin B synthesis)
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GPATCH2L G patch domain containing 2-like
GPX2 glutathione peroxidase 2
HAMP hepcidin antimicrobial peptide
HIST1H2BC histone cluster 1, H2bc
HIST1H4D histone cluster 1, H4d
HNRNPA3P1 heterogeneous nuclear ribonucleoprotein A3 pseudogene 1
HOXC5 homeobox C5
HOXD11 homeobox D11
HSPA1L heat shock 70kDa protein 1-like
IL1RAPL2 interleukin 1 receptor accessory protein-like 2
KAT2A K(lysine) acetyltransferase 2A
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KCNQ3 potassium channel, voltage gated KQT-like subfamily Q, member 3
KIF13B kinesin family member 13B
KLK5 kallikrein-related peptidase 5
LMO2 LIM domain only 2 (rhombotin-like 1)
LRRC61 leucine rich repeat containing 61
LYZ lysozyme
MMP15 matrix metallopeptidase 15 (membrane-inserted)
MVD mevalonate (diphospho) decarboxylase
MVP major vault protein
MYO1E myosin IE
NAV2 neuron navigator 2
NBEAL2 neurobeachin-like 2
NPFFR1 neuropeptide FF receptor 1
ONECUT2 one cut homeobox 2
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
PAIP2B poly(A) binding protein interacting protein 2B
PARP12 poly (ADP-ribose) polymerase family, member 12
PDK2 pyruvate dehydrogenase kinase, isozyme 2
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PLD2 phospholipase D2
PODNL1 podocan-like 1
RCOR3 REST corepressor 3
RFTN1 raftlin, lipid raft linker 1
RNF2 ring finger protein 2
SDC3 syndecan 3
SLC22A14 solute carrier family 22, member 14
SPIDR scaffolding protein involved in DNA repair
STAB2 stabilin 2
STAG3 stromal antigen 3
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
SYNGR3 synaptogyrin 3
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TMEM120B transmembrane protein 120B
TMEM180 transmembrane protein 180
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TRAF2 TNF receptor-associated factor 2
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TSPAN15 tetraspanin 15
TTC23 tetratricopeptide repeat domain 23
TUBA3C tubulin, alpha 3c
WDR91 WD repeat domain 91
ZNF134 zinc finger protein 134
ZNF16 zinc finger protein 16
ZNF510 zinc finger protein 510
ZNF767P zinc finger family member 767, pseudogene