probucol-5261 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the probucol-5261 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
A2M alpha-2-macroglobulin
AADAC arylacetamide deacetylase
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
ADAMTS7 ADAM metallopeptidase with thrombospondin type 1 motif, 7
AIM1L absent in melanoma 1-like
AKAP8L A kinase (PRKA) anchor protein 8-like
APOC1 apolipoprotein C-I
ARL4C ADP-ribosylation factor-like 4C
ARSD arylsulfatase D
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
BAIAP3 BAI1-associated protein 3
BAZ2A bromodomain adjacent to zinc finger domain, 2A
BCL2 B-cell CLL/lymphoma 2
BRF1 BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit
C11ORF16 chromosome 11 open reading frame 16
C19ORF66 chromosome 19 open reading frame 66
C3 complement component 3
CALD1 caldesmon 1
CAMK2B calcium/calmodulin-dependent protein kinase II beta
CD82 CD82 molecule
CD83 CD83 molecule
CD93 CD93 molecule
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CLCN4 chloride channel, voltage-sensitive 4
CRTAC1 cartilage acidic protein 1
DCSTAMP dendrocyte expressed seven transmembrane protein
DENND1C DENN/MADD domain containing 1C
DLX4 distal-less homeobox 4
DTNA dystrobrevin, alpha
EDA ectodysplasin A
EFCAB11 EF-hand calcium binding domain 11
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2
EMID1 EMI domain containing 1
FBN1 fibrillin 1
FBXO2 F-box protein 2
FBXO40 F-box protein 40
FHL1 four and a half LIM domains 1
FUT3 fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group)
FUT4 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
GEM GTP binding protein overexpressed in skeletal muscle
GGA1 golgi-associated, gamma adaptin ear containing, ARF binding protein 1
GM2A GM2 ganglioside activator
GPER1 G protein-coupled estrogen receptor 1
GPR143 G protein-coupled receptor 143
GPR37L1 G protein-coupled receptor 37 like 1
GPT glutamic-pyruvate transaminase (alanine aminotransferase)
GRIP2 glutamate receptor interacting protein 2
GRK5 G protein-coupled receptor kinase 5
H6PD hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)
HNF4A hepatocyte nuclear factor 4, alpha
IGL immunoglobulin lambda locus
INO80D INO80 complex subunit D
KCNG1 potassium channel, voltage gated modifier subfamily G, member 1
KDM4B lysine (K)-specific demethylase 4B
KMT2A lysine (K)-specific methyltransferase 2A
LAT2 linker for activation of T cells family, member 2
LDB3 LIM domain binding 3
LTC4S leukotriene C4 synthase
MSI1 musashi RNA-binding protein 1
MUC5B mucin 5B, oligomeric mucus/gel-forming
MX1 MX dynamin-like GTPase 1
MYO15B myosin XVB
NDUFAF5 NADH dehydrogenase (ubiquinone) complex I, assembly factor 5
NLGN1 neuroligin 1
NOTCH4 notch 4
NR2E3 nuclear receptor subfamily 2, group E, member 3
PAPPA2 pappalysin 2
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PLA2R1 phospholipase A2 receptor 1, 180kDa
PLAC4 placenta-specific 4
PLAT plasminogen activator, tissue
PMEL premelanosome protein
POPDC3 popeye domain containing 3
PQBP1 polyglutamine binding protein 1
PRLH prolactin releasing hormone
PSG4 pregnancy specific beta-1-glycoprotein 4
PTGDS prostaglandin D2 synthase 21kDa (brain)
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RGS10 regulator of G-protein signaling 10
RPL35A ribosomal protein L35a
RSPH14 radial spoke head 14 homolog (Chlamydomonas)
RUNX1 runt-related transcription factor 1
SCAND2P SCAN domain containing 2 pseudogene
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2
SPG20 spastic paraplegia 20 (Troyer syndrome)
SVIL supervillin
SYT11 synaptotagmin XI
TAGLN3 transgelin 3
TBC1D22A TBC1 domain family, member 22A
TM4SF1 transmembrane 4 L six family member 1
TRAIP TRAF interacting protein
TRIM10 tripartite motif containing 10
TSC2 tuberous sclerosis 2
UPK3B uroplakin 3B
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae)
ZMAT4 zinc finger, matrin-type 4
ZMIZ2 zinc finger, MIZ-type containing 2
ZNF224 zinc finger protein 224
ZNF423 zinc finger protein 423

decreased expression

Symbol Name
ABHD17B abhydrolase domain containing 17B
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17
AXIN1 axin 1
BHLHB9 basic helix-loop-helix domain containing, class B, 9
BLNK B-cell linker
BMP15 bone morphogenetic protein 15
C16ORF59 chromosome 16 open reading frame 59
C1QTNF9B-AS1 C1QTNF9B antisense RNA 1
C2ORF44 chromosome 2 open reading frame 44
CA11 carbonic anhydrase XI
CAMK4 calcium/calmodulin-dependent protein kinase IV
CCDC9 coiled-coil domain containing 9
CCNO cyclin O
CCRN4L CCR4 carbon catabolite repression 4-like (S. cerevisiae)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLCN2 chloride channel, voltage-sensitive 2
CLCN5 chloride channel, voltage-sensitive 5
CLCN6 chloride channel, voltage-sensitive 6
CLDN1 claudin 1
CRABP1 cellular retinoic acid binding protein 1
CRELD1 cysteine-rich with EGF-like domains 1
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
DDIT3 DNA-damage-inducible transcript 3
DIXDC1 DIX domain containing 1
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EFNA3 ephrin-A3
ETV6 ets variant 6
EVPL envoplakin
FA2H fatty acid 2-hydroxylase
FAM53C family with sequence similarity 53, member C
FBXO31 F-box protein 31
FRS2 fibroblast growth factor receptor substrate 2
FSD1 fibronectin type III and SPRY domain containing 1
FUZ fuzzy planar cell polarity protein
GAS8 growth arrest-specific 8
GLB1L2 galactosidase, beta 1-like 2
GNG3 guanine nucleotide binding protein (G protein), gamma 3
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GPX2 glutathione peroxidase 2
GRAMD4 GRAM domain containing 4
GRINA glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)
GTF2I general transcription factor IIi
HIST1H2AM histone cluster 1, H2am
HIST1H4F histone cluster 1, H4f
HYI hydroxypyruvate isomerase (putative)
IFI27 interferon, alpha-inducible protein 27
IGFBP4 insulin-like growth factor binding protein 4
IREB2 iron-responsive element binding protein 2
KDM8 lysine (K)-specific demethylase 8
KIAA0319L KIAA0319-like
KIAA0754 KIAA0754
LAMB3 laminin, beta 3
LRRC20 leucine rich repeat containing 20
LRRC6 leucine rich repeat containing 6
MAP1S microtubule-associated protein 1S
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MAZ MYC-associated zinc finger protein (purine-binding transcription factor)
MITF microphthalmia-associated transcription factor
MRPS18C mitochondrial ribosomal protein S18C
MUC3A mucin 3A, cell surface associated
MUL1 mitochondrial E3 ubiquitin protein ligase 1
MVD mevalonate (diphospho) decarboxylase
MXD3 MAX dimerization protein 3
NEUROD4 neuronal differentiation 4
NME5 NME/NM23 family member 5
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein
OR1D2 olfactory receptor, family 1, subfamily D, member 2
PACS1 phosphofurin acidic cluster sorting protein 1
PADI2 peptidyl arginine deiminase, type II
PCDHB13 protocadherin beta 13
PILRB paired immunoglobin-like type 2 receptor beta
PLA2G4C phospholipase A2, group IVC (cytosolic, calcium-independent)
PLEKHA6 pleckstrin homology domain containing, family A member 6
PLEKHO2 pleckstrin homology domain containing, family O member 2
PMCH pro-melanin-concentrating hormone
POLR3D polymerase (RNA) III (DNA directed) polypeptide D, 44kDa
RAB3D RAB3D, member RAS oncogene family
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RAD54L2 RAD54-like 2 (S. cerevisiae)
RIPK4 receptor-interacting serine-threonine kinase 4
RNF2 ring finger protein 2
RNF39 ring finger protein 39
S100A4 S100 calcium binding protein A4
SLC27A6 solute carrier family 27 (fatty acid transporter), member 6
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SOX12 SRY (sex determining region Y)-box 12
SP1 Sp1 transcription factor
STX5 syntaxin 5
SYNGR3 synaptogyrin 3
TCTA T-cell leukemia translocation altered
TH tyrosine hydroxylase
TNS2 tensin 2
TOM1 target of myb1 (chicken)
TRIP10 thyroid hormone receptor interactor 10
ULBP2 UL16 binding protein 2
VLDLR very low density lipoprotein receptor
ZNF747 zinc finger protein 747