procainamide-5663 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the procainamide-5663 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABO ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
AFF2 AF4/FMR2 family, member 2
APBA2 amyloid beta (A4) precursor protein-binding, family A, member 2
BCL2A1 BCL2-related protein A1
BHMT2 betaine--homocysteine S-methyltransferase 2
BMP8A bone morphogenetic protein 8a
CAMK2B calcium/calmodulin-dependent protein kinase II beta
CD48 CD48 molecule
CDRT1 CMT1A duplicated region transcript 1
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEP97 centrosomal protein 97kDa
CFAP69 cilia and flagella associated protein 69
CNTNAP2 contactin associated protein-like 2
CPED1 cadherin-like and PC-esterase domain containing 1
CXCR4 chemokine (C-X-C motif) receptor 4
DNAJB12 DnaJ (Hsp40) homolog, subfamily B, member 12
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DUSP6 dual specificity phosphatase 6
EFHC2 EF-hand domain (C-terminal) containing 2
EGF epidermal growth factor
ESR1 estrogen receptor 1
EXOSC2 exosome component 2
FAM149B1 family with sequence similarity 149, member B1
FCGR2C Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
FGFR1 fibroblast growth factor receptor 1
FHIT fragile histidine triad
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
GCNT4 glucosaminyl (N-acetyl) transferase 4, core 2
GH1 growth hormone 1
GPR153 G protein-coupled receptor 153
HCLS1 hematopoietic cell-specific Lyn substrate 1
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DRB6 major histocompatibility complex, class II, DR beta 6 (pseudogene)
ICAM1 intercellular adhesion molecule 1
IDUA iduronidase, alpha-L-
IGFBP5 insulin-like growth factor binding protein 5
IL9 interleukin 9
INPP5B inositol polyphosphate-5-phosphatase, 75kDa
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6
LINC00574 long intergenic non-protein coding RNA 574
LOXL3 lysyl oxidase-like 3
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1
MCAM melanoma cell adhesion molecule
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MMP3 matrix metallopeptidase 3
NF1 neurofibromin 1
NMT1 N-myristoyltransferase 1
NOD1 nucleotide-binding oligomerization domain containing 1
P2RY1 purinergic receptor P2Y, G-protein coupled, 1
PCDH7 protocadherin 7
PCDHB17P protocadherin beta 17 pseudogene
PCDHGA8 protocadherin gamma subfamily A, 8
PDZD2 PDZ domain containing 2
PHLPP2 PH domain and leucine rich repeat protein phosphatase 2
PIK3R5 phosphoinositide-3-kinase, regulatory subunit 5
PLA2G5 phospholipase A2, group V
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha
PPP4R4 protein phosphatase 4, regulatory subunit 4
PRAMEF12 PRAME family member 12
PRB1 proline-rich protein BstNI subfamily 1
PRB3 proline-rich protein BstNI subfamily 3
PXN paxillin
RAI2 retinoic acid induced 2
RHAG Rh-associated glycoprotein
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
SCN11A sodium channel, voltage gated, type XI alpha subunit
SEMA3G sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SGK2 serum/glucocorticoid regulated kinase 2
SH3BP2 SH3-domain binding protein 2
SIX3 SIX homeobox 3
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC22A18AS solute carrier family 22 (organic cation transporter), member 18 antisense
SMC1A structural maintenance of chromosomes 1A
SNTA1 syntrophin, alpha 1
SPTBN1 spectrin, beta, non-erythrocytic 1
SSTR4 somatostatin receptor 4
STOML1 stomatin (EPB72)-like 1
SV2C synaptic vesicle glycoprotein 2C
TBL2 transducin (beta)-like 2
TCF7L1 transcription factor 7-like 1 (T-cell specific, HMG-box)
TCP10 t-complex 10
TEX15 testis expressed 15
TEX40 testis expressed 40
TLR4 toll-like receptor 4
TMEM242 transmembrane protein 242
TMPRSS15 transmembrane protease, serine 15
TNFRSF9 tumor necrosis factor receptor superfamily, member 9
TNP2 transition protein 2 (during histone to protamine replacement)
TP53I11 tumor protein p53 inducible protein 11
TRAV8-3 T cell receptor alpha variable 8-3
TTLL4 tubulin tyrosine ligase-like family member 4
UBE2B ubiquitin-conjugating enzyme E2B
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae)
WDR62 WD repeat domain 62
ZMAT4 zinc finger, matrin-type 4

decreased expression

Symbol Name
ACVR2B activin A receptor, type IIB
ADAM15 ADAM metallopeptidase domain 15
ADGRE5 adhesion G protein-coupled receptor E5
AGBL5 ATP/GTP binding protein-like 5
AMT aminomethyltransferase
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26
ARRB1 arrestin, beta 1
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
BCAS1 breast carcinoma amplified sequence 1
BMP4 bone morphogenetic protein 4
BSG basigin (Ok blood group)
BST2 bone marrow stromal cell antigen 2
C11ORF80 chromosome 11 open reading frame 80
CALCOCO1 calcium binding and coiled-coil domain 1
CCDC132 coiled-coil domain containing 132
CCNO cyclin O
CCT6B chaperonin containing TCP1, subunit 6B (zeta 2)
CD302 CD302 molecule
COG4 component of oligomeric golgi complex 4
CORT cortistatin
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
CTSV cathepsin V
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
DGAT1 diacylglycerol O-acyltransferase 1
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DUSP2 dual specificity phosphatase 2
EFCAB2 EF-hand calcium binding domain 2
FAAH fatty acid amide hydrolase
FAM110B family with sequence similarity 110, member B
FBXL15 F-box and leucine-rich repeat protein 15
FLT4 fms-related tyrosine kinase 4
FSTL3 follistatin-like 3 (secreted glycoprotein)
GNL1 guanine nucleotide binding protein-like 1
GTF2I general transcription factor IIi
HOMER2 homer scaffolding protein 2
HOXD11 homeobox D11
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled
IFT54 intraflagellar transport 54
INCENP inner centromere protein antigens 135/155kDa
IRF2 interferon regulatory factor 2
ITGA10 integrin, alpha 10
JMJD4 jumonji domain containing 4
KLF3 Kruppel-like factor 3 (basic)
KRT8P12 keratin 8 pseudogene 12
LINC00115 long intergenic non-protein coding RNA 115
LOC100286895 cell division cycle 27 homolog pseudogene
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MDM4 MDM4, p53 regulator
MGC12488
MTHFD2L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like
MYL5 myosin, light chain 5, regulatory
NIT1 nitrilase 1
NKX3-2 NK3 homeobox 2
NR1H3 nuclear receptor subfamily 1, group H, member 3
NTHL1 nth endonuclease III-like 1 (E. coli)
NXPE3 neurexophilin and PC-esterase domain family, member 3
ODF2 outer dense fiber of sperm tails 2
OTUD3 OTU deubiquitinase 3
PARP12 poly (ADP-ribose) polymerase family, member 12
PCDHB3 protocadherin beta 3
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime
PGR progesterone receptor
PITX2 paired-like homeodomain 2
PLA2G10 phospholipase A2, group X
PLCXD1 phosphatidylinositol-specific phospholipase C, X domain containing 1
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRKX protein kinase, X-linked
RAB3D RAB3D, member RAS oncogene family
RCAN3 RCAN family member 3
RPGRIP1L RPGRIP1-like
RPL13P5 ribosomal protein L13 pseudogene 5
RRNAD1 ribosomal RNA adenine dimethylase domain containing 1
SH2D4A SH2 domain containing 4A
SIL1 SIL1 nucleotide exchange factor
SIRAL2 SIR2 antiphage like 2
SIRT2 sirtuin 2
SLC26A6 solute carrier family 26 (anion exchanger), member 6
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SPINK5 serine peptidase inhibitor, Kazal type 5
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1
TAOK1 TAO kinase 1
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TESK1 testis-specific kinase 1
THYN1 thymocyte nuclear protein 1
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein
UNC119 unc-119 homolog (C. elegans)
VWA1 von Willebrand factor A domain containing 1
ZKSCAN3 zinc finger with KRAB and SCAN domains 3
ZNF250 zinc finger protein 250
ZNF324 zinc finger protein 324
ZNF606 zinc finger protein 606
ZNF8 zinc finger protein 8
ZSCAN26 zinc finger and SCAN domain containing 26