procarbazine-5452 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the procarbazine-5452 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
A4GNT alpha-1,4-N-acetylglucosaminyltransferase
ABI2 abl-interactor 2
ACRV1 acrosomal vesicle protein 1
APLP1 amyloid beta (A4) precursor-like protein 1
APOC4 apolipoprotein C-IV
BARX2 BARX homeobox 2
BTF3P11 basic transcription factor 3 pseudogene 11
C1ORF54 chromosome 1 open reading frame 54
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit
CACNB1 calcium channel, voltage-dependent, beta 1 subunit
CACNG1 calcium channel, voltage-dependent, gamma subunit 1
CASP10 caspase 10, apoptosis-related cysteine peptidase
CCDC132 coiled-coil domain containing 132
CFAP69 cilia and flagella associated protein 69
CLCN4 chloride channel, voltage-sensitive 4
CNKSR2 connector enhancer of kinase suppressor of Ras 2
COL1A2 collagen, type I, alpha 2
CRTC1 CREB regulated transcription coactivator 1
DGCR5 DiGeorge syndrome critical region gene 5 (non-protein coding)
DPF3 D4, zinc and double PHD fingers, family 3
DRD2 dopamine receptor D2
DUSP6 dual specificity phosphatase 6
EFNB3 ephrin-B3
EMC3 ER membrane protein complex subunit 3
ETV6 ets variant 6
F9 coagulation factor IX
FBXW4P1 F-box and WD repeat domain containing 4 pseudogene 1
FFAR3 free fatty acid receptor 3
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GM2A GM2 ganglioside activator
GRB10 growth factor receptor-bound protein 10
HIPK3 homeodomain interacting protein kinase 3
HIST1H4F histone cluster 1, H4f
HS3ST2 heparan sulfate (glucosamine) 3-O-sulfotransferase 2
IFNA2 interferon, alpha 2
IL10RA interleukin 10 receptor, alpha
IL17RC interleukin 17 receptor C
ING4 inhibitor of growth family, member 4
JAG1 jagged 1
MAOA monoamine oxidase A
MBD2 methyl-CpG binding domain protein 2
MBD3 methyl-CpG binding domain protein 3
MCAM melanoma cell adhesion molecule
MOG myelin oligodendrocyte glycoprotein
MPL MPL proto-oncogene, thrombopoietin receptor
MUC4 mucin 4, cell surface associated
N4BP2L1 NEDD4 binding protein 2-like 1
NAP1L3 nucleosome assembly protein 1-like 3
NR4A2 nuclear receptor subfamily 4, group A, member 2
OPRK1 opioid receptor, kappa 1
OSBPL10 oxysterol binding protein-like 10
PAIP2B poly(A) binding protein interacting protein 2B
PCDHGA8 protocadherin gamma subfamily A, 8
PEG10 paternally expressed 10
PID1 phosphotyrosine interaction domain containing 1
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLCD1 phospholipase C, delta 1
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PPP2R1B protein phosphatase 2, regulatory subunit A, beta
PRAMEF11 PRAME family member 11
PSG11 pregnancy specific beta-1-glycoprotein 11
PTP4A3 protein tyrosine phosphatase type IVA, member 3
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PYHIN1 pyrin and HIN domain family, member 1
RABEP2 rabaptin, RAB GTPase binding effector protein 2
RASAL2 RAS protein activator like 2
RETN resistin
RGS20 regulator of G-protein signaling 20
RIMS1 regulating synaptic membrane exocytosis 1
RIMS3 regulating synaptic membrane exocytosis 3
RNASE4 ribonuclease, RNase A family, 4
RNASE6 ribonuclease, RNase A family, k6
RPL23AP32 ribosomal protein L23a pseudogene 32
RPL35A ribosomal protein L35a
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RUNX1 runt-related transcription factor 1
SCAPER S-phase cyclin A-associated protein in the ER
SH3BP1 SH3-domain binding protein 1
SKAP1 src kinase associated phosphoprotein 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SMAD6 SMAD family member 6
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SPINK5 serine peptidase inhibitor, Kazal type 5
SPRR2B small proline-rich protein 2B
SRP72 signal recognition particle 72kDa
SSX3 synovial sarcoma, X breakpoint 3
STARD3 StAR-related lipid transfer (START) domain containing 3
SULT4A1 sulfotransferase family 4A, member 1
TBC1D22A TBC1 domain family, member 22A
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
THRB thyroid hormone receptor, beta
TRPA1 transient receptor potential cation channel, subfamily A, member 1
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VWA1 von Willebrand factor A domain containing 1
ZEB1 zinc finger E-box binding homeobox 1
ZNF155 zinc finger protein 155
ZNF592 zinc finger protein 592

decreased expression

Symbol Name
A2M alpha-2-macroglobulin
ACBD4 acyl-CoA binding domain containing 4
AHDC1 AT hook, DNA binding motif, containing 1
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ANXA2P3 annexin A2 pseudogene 3
ARHGAP10 Rho GTPase activating protein 10
ARMC4 armadillo repeat containing 4
ATP10D ATPase, class V, type 10D
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BFSP1 beaded filament structural protein 1, filensin
BST2 bone marrow stromal cell antigen 2
C11ORF80 chromosome 11 open reading frame 80
C2ORF54 chromosome 2 open reading frame 54
CD82 CD82 molecule
CDK3 cyclin-dependent kinase 3
CIDEC cell death-inducing DFFA-like effector c
CINP cyclin-dependent kinase 2 interacting protein
CLGN calmegin
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant
CORT cortistatin
CST6 cystatin E/M
CTAGE9 CTAGE family, member 9
DENND4A DENN/MADD domain containing 4A
DMTN dematin actin binding protein
FADS2 fatty acid desaturase 2
FAM212B family with sequence similarity 212, member B
FER fer (fps/fes related) tyrosine kinase
FKBP1B FK506 binding protein 1B, 12.6 kDa
FLJ22184
GMPR guanosine monophosphate reductase
GPR143 G protein-coupled receptor 143
H2AFY2 H2A histone family, member Y2
HIST1H1D histone cluster 1, H1d
HIST1H2AJ histone cluster 1, H2aj
HIST1H2BJ histone cluster 1, H2bj
HOXC5 homeobox C5
IDI2-AS1 IDI2 antisense RNA 1
IFI6 interferon, alpha-inducible protein 6
IGFBP6 insulin-like growth factor binding protein 6
INPP5J inositol polyphosphate-5-phosphatase J
IRF6 interferon regulatory factor 6
KLF3 Kruppel-like factor 3 (basic)
KPNA5 karyopherin alpha 5 (importin alpha 6)
LIN7A lin-7 homolog A (C. elegans)
LINC00597 long intergenic non-protein coding RNA 597
LRP3 low density lipoprotein receptor-related protein 3
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3
MRPL41 mitochondrial ribosomal protein L41
MYO1F myosin IF
NME5 NME/NM23 family member 5
NOL10 nucleolar protein 10
NPM3 nucleophosmin/nucleoplasmin 3
OSMR oncostatin M receptor
PER3 period circadian clock 3
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PMCHL1 pro-melanin-concentrating hormone-like 1, pseudogene
PODNL1 podocan-like 1
POMT2 protein-O-mannosyltransferase 2
PRKCE protein kinase C, epsilon
PROS1 protein S (alpha)
PRR4 proline rich 4 (lacrimal)
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
PSG4 pregnancy specific beta-1-glycoprotein 4
RASAL1 RAS protein activator like 1 (GAP1 like)
RGS17 regulator of G-protein signaling 17
RLN1 relaxin 1
RNF122 ring finger protein 122
RSPH14 radial spoke head 14 homolog (Chlamydomonas)
S100A9 S100 calcium binding protein A9
SARS2 seryl-tRNA synthetase 2, mitochondrial
SAYSD1 SAYSVFN motif domain containing 1
SCN1B sodium channel, voltage gated, type I beta subunit
SDC3 syndecan 3
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SPON2 spondin 2, extracellular matrix protein
SREK1IP1 SREK1-interacting protein 1
SSBP3 single stranded DNA binding protein 3
STEAP1 six transmembrane epithelial antigen of the prostate 1
STK16 serine/threonine kinase 16
TAGLN transgelin
TCTN2 tectonic family member 2
TMEM120B transmembrane protein 120B
TMEM121 transmembrane protein 121
TMPRSS3 transmembrane protease, serine 3
TNFRSF14 tumor necrosis factor receptor superfamily, member 14
TUBA3C tubulin, alpha 3c
TUBG2 tubulin, gamma 2
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific
TWSG1 twisted gastrulation BMP signaling modulator 1
VASH2 vasohibin 2
ZBTB48 zinc finger and BTB domain containing 48
ZC3H3 zinc finger CCCH-type containing 3
ZFP37 ZFP37 zinc finger protein
ZNF205 zinc finger protein 205
ZNF248 zinc finger protein 248
ZNF282 zinc finger protein 282
ZNF446 zinc finger protein 446