progeria Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores
Category disease or phenotype associations
Type disease
Description OMIM mapping confirmed by DO. [SN]. (Human Disease Ontology, DOID_3911)
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Genes

130 genes co-occuring with the disease progeria in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
LMNA lamin A/C 3.23085
ZMPSTE24 zinc metallopeptidase STE24 2.66802
LMNB1 lamin B1 1.78579
WRN Werner syndrome, RecQ helicase-like 1.64218
SUN1 Sad1 and UNC84 domain containing 1 1.55247
EMD emerin 1.54318
BANF1 barrier to autointegration factor 1 1.3987
LMNB2 lamin B2 1.35289
PGBD3 piggyBac transposable element derived 3 1.32236
XPA xeroderma pigmentosum, complementation group A 1.08999
PGGT1B protein geranylgeranyltransferase type I, beta subunit 1.08495
RCE1 Ras converting CAAX endopeptidase 1 1.0837
GTF2H4 general transcription factor IIH, polypeptide 4, 52kDa 1.00203
GGT2 gamma-glutamyltransferase 2 0.955361
ERCC4 excision repair cross-complementation group 4 0.918848
PCGF2 polycomb group ring finger 2 0.896641
ICMT isoprenylcysteine carboxyl methyltransferase 0.866321
TPR translocated promoter region, nuclear basket protein 0.829459
TRDMT1 tRNA aspartic acid methyltransferase 1 0.811001
NUP107 nucleoporin 107kDa 0.798282
SRSF6 serine/arginine-rich splicing factor 6 0.791721
NDC1 NDC1 transmembrane nucleoporin 0.767576
ERCC2 excision repair cross-complementation group 2 0.749237
PODXL podocalyxin-like 0.74883
BSCL2 Berardinelli-Seip congenital lipodystrophy 2 (seipin) 0.737054
ERCC1 excision repair cross-complementation group 1 0.729357
B4GALT3 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3 0.722886
GGT1 gamma-glutamyltransferase 1 0.721673
ING1 inhibitor of growth family, member 1 0.700722
GORAB golgin, RAB6-interacting 0.691896
NCAPD3 non-SMC condensin II complex, subunit D3 0.686291
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) 0.659215
ATM ATM serine/threonine kinase 0.652484
SF1 splicing factor 1 0.651694
NAP1L1 nucleosome assembly protein 1-like 1 0.651694
LBR lamin B receptor 0.646165
H2AFX H2A histone family, member X 0.622183
TAF10 TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa 0.615921
CHURC1 churchill domain containing 1 0.612401
PDGFA platelet-derived growth factor alpha polypeptide 0.607714
PYCR1 pyrroline-5-carboxylate reductase 1 0.6003
GPS1 G protein pathway suppressor 1 0.596012
ALDH18A1 aldehyde dehydrogenase 18 family, member A1 0.595623
RANBP1 RAN binding protein 1 0.590558
PNPT1 polyribonucleotide nucleotidyltransferase 1 0.58005
NAT10 N-acetyltransferase 10 (GCN5-related) 0.55945
PRELP proline/arginine-rich end leucine-rich repeat protein 0.554403
SIRT1 sirtuin 1 0.550134
UBE2I ubiquitin-conjugating enzyme E2I 0.535796
HSPB2 heat shock 27kDa protein 2 0.535796
AGPAT2 1-acylglycerol-3-phosphate O-acyltransferase 2 0.531154
ROBO3 roundabout, axon guidance receptor, homolog 3 (Drosophila) 0.524974
HGS hepatocyte growth factor-regulated tyrosine kinase substrate 0.524588
RFC5 replication factor C (activator 1) 5, 36.5kDa 0.512264
RFC3 replication factor C (activator 1) 3, 38kDa 0.498467
MAD2L1P1 MAD2 mitotic arrest deficient-like 1 (yeast) pseudogene 1 0.486646
CDKN3 cyclin-dependent kinase inhibitor 3 0.483604
FOXQ1 forkhead box Q1 0.471089
RFC4 replication factor C (activator 1) 4, 37kDa 0.465038
CBX5 chromobox homolog 5 0.462772
ME3 malic enzyme 3, NADP(+)-dependent, mitochondrial 0.457864
KL klotho 0.457487
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) 0.449194
IGF1 insulin-like growth factor 1 (somatomedin C) 0.442042
WRNIP1 Werner helicase interacting protein 1 0.437906
G6PD glucose-6-phosphate dehydrogenase 0.43753
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.431144
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 0.42364
CORT cortistatin 0.418019
ERCC6 excision repair cross-complementation group 6 0.402692
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 0.401945
TWIST2 twist family bHLH transcription factor 2 0.401199
MEOX2 mesenchyme homeobox 2 0.382966
NUP153 nucleoporin 153kDa 0.382223
RFC1 replication factor C (activator 1) 1, 145kDa 0.374438
HIP1 huntingtin interacting protein 1 0.369628
PTRF polymerase I and transcript release factor 0.366301
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) 0.357446
HIST1H4H histone cluster 1, H4h 0.356709
HIST1H4I histone cluster 1, H4i 0.356709
HIST1H4J histone cluster 1, H4j 0.356709
HIST1H4K histone cluster 1, H4k 0.356709
HIST1H4D histone cluster 1, H4d 0.356709
HIST1H4E histone cluster 1, H4e 0.356709
HIST2H4B histone cluster 2, H4b 0.356709
HIST1H4B histone cluster 1, H4b 0.356709
HIST1H4C histone cluster 1, H4c 0.356709
HIST1H4F histone cluster 1, H4f 0.356709
HIST1H4A histone cluster 1, H4a 0.356709
HIST2H4A histone cluster 2, H4a 0.355972
HIST4H4 histone cluster 4, H4 0.354131
HIST1H4L histone cluster 1, H4l 0.354131
LEMD3 LEM domain containing 3 0.353395
TP53 tumor protein p53 0.353027
TRPV2 transient receptor potential cation channel, subfamily V, member 2 0.345675
BCAN brevican 0.3292
CTRL chymotrypsin-like 0.320454
HPSE2 heparanase 2 (inactive) 0.316092
SET SET nuclear proto-oncogene 0.312827
PGD phosphogluconate dehydrogenase 0.311014
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.30848
MKL1 megakaryoblastic leukemia (translocation) 1 0.297291
SFRP5 secreted frizzled-related protein 5 0.286519
ATP6V0A2 ATPase, H+ transporting, lysosomal V0 subunit a2 0.284728
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D 0.28151
PCNT pericentrin 0.280082
CTSL cathepsin L 0.278297
RFC2 replication factor C (activator 1) 2, 40kDa 0.270819
SCAI suppressor of cancer cell invasion 0.270464
XPC xeroderma pigmentosum, complementation group C 0.269043
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta 0.264077
HIST2H3PS2 histone cluster 2, H3, pseudogene 2 0.261245
H3F3A H3 histone, family 3A 0.254888
H3F3B H3 histone, family 3B (H3.3B) 0.254888
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled 0.253127
AGPS alkylglycerone phosphate synthase 0.24715
MYOCD myocardin 0.220766
RAD51 RAD51 recombinase 0.211597
INS insulin 0.192031
BRD4 bromodomain containing 4 0.188326
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B 0.188022
GP2 glycoprotein 2 (zymogen granule membrane) 0.18621
KRT14 keratin 14, type I 0.18151
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 0.180367
DDB1 damage-specific DNA binding protein 1, 127kDa 0.180084
ACAN aggrecan 0.172799
HP haptoglobin 0.170299
BMP2 bone morphogenetic protein 2 0.168854
HPR haptoglobin-related protein 0.166544
PDX1 pancreatic and duodenal homeobox 1 0.159658