proglumide-3972 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the proglumide-3972 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ALDOB aldolase B, fructose-bisphosphate
ANO2 anoctamin 2, calcium activated chloride channel
ARMC4 armadillo repeat containing 4
ARTN artemin
ASIC2 acid sensing (proton gated) ion channel 2
ATP11A ATPase, class VI, type 11A
C1QTNF1 C1q and tumor necrosis factor related protein 1
C3 complement component 3
CABP1 calcium binding protein 1
CAMKV CaM kinase-like vesicle-associated
CARD10 caspase recruitment domain family, member 10
CCDC87 coiled-coil domain containing 87
CCL24 chemokine (C-C motif) ligand 24
CD8A CD8a molecule
CEBPE CCAAT/enhancer binding protein (C/EBP), epsilon
CHRDL1 chordin-like 1
CLEC2B C-type lectin domain family 2, member B
COL1A1 collagen, type I, alpha 1
COLGALT2 collagen beta(1-O)galactosyltransferase 2
CXXC4 CXXC finger protein 4
DNASE1L2 deoxyribonuclease I-like 2
DOCK3 dedicator of cytokinesis 3
EDA ectodysplasin A
EGR4 early growth response 4
EPB41L4B erythrocyte membrane protein band 4.1 like 4B
ERCC2 excision repair cross-complementation group 2
FGF2 fibroblast growth factor 2 (basic)
FMO6P flavin containing monooxygenase 6 pseudogene
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1
GNG13 guanine nucleotide binding protein (G protein), gamma 13
GPR68 G protein-coupled receptor 68
GRIA3 glutamate receptor, ionotropic, AMPA 3
GYG2 glycogenin 2
GYPB glycophorin B (MNS blood group)
HDAC7 histone deacetylase 7
HIST1H3I histone cluster 1, H3i
ICOSLG inducible T-cell co-stimulator ligand
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IGHA1 immunoglobulin heavy constant alpha 1
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
KIAA1462 KIAA1462
KIF24 kinesin family member 24
KIR2DL1 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1
KRT16 keratin 16, type I
LARP4B La ribonucleoprotein domain family, member 4B
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1
MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3
MC5R melanocortin 5 receptor
MECOM MDS1 and EVI1 complex locus
MEF2D myocyte enhancer factor 2D
MTMR1 myotubularin related protein 1
MYCNOS MYCN opposite strand
NDUFB7 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa
NUP88 nucleoporin 88kDa
OXCT2 3-oxoacid CoA transferase 2
PCDHGB6 protocadherin gamma subfamily B, 6
PCDHGC3 protocadherin gamma subfamily C, 3
PCNXL2 pecanex-like 2 (Drosophila)
PEG3 paternally expressed 3
PER1 period circadian clock 1
PHACTR1 phosphatase and actin regulator 1
PHLPP2 PH domain and leucine rich repeat protein phosphatase 2
PLCB2 phospholipase C, beta 2
PLCH1 phospholipase C, eta 1
PLLP plasmolipin
PMFBP1 polyamine modulated factor 1 binding protein 1
PPP2R1B protein phosphatase 2, regulatory subunit A, beta
PRM1 protamine 1
PTK2B protein tyrosine kinase 2 beta
RAB6B RAB6B, member RAS oncogene family
RECQL5 RecQ protein-like 5
RORC RAR-related orphan receptor C
RUNX1 runt-related transcription factor 1
SAFB scaffold attachment factor B
SEMG2 semenogelin II
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SNX29 sorting nexin 29
SPTBN1 spectrin, beta, non-erythrocytic 1
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
STMN2 stathmin 2
SYCP1 synaptonemal complex protein 1
SYNDIG1 synapse differentiation inducing 1
T T, brachyury homolog (mouse)
TAAR5 trace amine associated receptor 5
TCF4 transcription factor 4
TFR2 transferrin receptor 2
THAP3 THAP domain containing, apoptosis associated protein 3
TM4SF20 transmembrane 4 L six family member 20
TMEM259 transmembrane protein 259
TONSL tonsoku-like, DNA repair protein
TRAIP TRAF interacting protein
TSKS testis-specific serine kinase substrate
UBA6 ubiquitin-like modifier activating enzyme 6
UBR2 ubiquitin protein ligase E3 component n-recognin 2
URB1 URB1 ribosome biogenesis 1 homolog (S. cerevisiae)
VCAN versican
XYLB xylulokinase homolog (H. influenzae)

decreased expression

Symbol Name
ACPP acid phosphatase, prostate
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13
AFAP1 actin filament associated protein 1
ATP6V1G2 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2
BCAS1 breast carcinoma amplified sequence 1
BMP10 bone morphogenetic protein 10
C1ORF159 chromosome 1 open reading frame 159
CA1 carbonic anhydrase I
CCDC132 coiled-coil domain containing 132
CDON cell adhesion associated, oncogene regulated
CFHR4 complement factor H-related 4
CHRM3 cholinergic receptor, muscarinic 3
CLCN6 chloride channel, voltage-sensitive 6
CLGN calmegin
CNGB3 cyclic nucleotide gated channel beta 3
CPA4 carboxypeptidase A4
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
DUSP13 dual specificity phosphatase 13
EDN1 endothelin 1
EGFL7 EGF-like-domain, multiple 7
EHHADH enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase
EPB41L5 erythrocyte membrane protein band 4.1 like 5
FAM110B family with sequence similarity 110, member B
FGD1 FYVE, RhoGEF and PH domain containing 1
GAST gastrin
GFOD1 glucose-fructose oxidoreductase domain containing 1
GNA12 guanine nucleotide binding protein (G protein) alpha 12
GPR143 G protein-coupled receptor 143
GPRIN2 G protein regulated inducer of neurite outgrowth 2
GSTTP1 glutathione S-transferase theta pseudogene 1
HDAC11 histone deacetylase 11
HIST1H4D histone cluster 1, H4d
HYI hydroxypyruvate isomerase (putative)
IPO8 importin 8
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
KCNQ3 potassium channel, voltage gated KQT-like subfamily Q, member 3
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3
KIAA0754 KIAA0754
KRT15 keratin 15, type I
LAMP3 lysosomal-associated membrane protein 3
LMTK2 lemur tyrosine kinase 2
LRRC15 leucine rich repeat containing 15
MFSD6 major facilitator superfamily domain containing 6
MRPS18C mitochondrial ribosomal protein S18C
NES nestin
NIPSNAP3B nipsnap homolog 3B (C. elegans)
NME5 NME/NM23 family member 5
NOTCH4 notch 4
NSUN6 NOP2/Sun domain family, member 6
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
PAX9 paired box 9
PLAC4 placenta-specific 4
PLEKHO2 pleckstrin homology domain containing, family O member 2
PLSCR4 phospholipid scramblase 4
PREX2 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
PTPRM protein tyrosine phosphatase, receptor type, M
RAB3D RAB3D, member RAS oncogene family
RAB40C RAB40C, member RAS oncogene family
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2
RFXAP regulatory factor X-associated protein
RIBC2 RIB43A domain with coiled-coils 2
RND1 Rho family GTPase 1
RNF125 ring finger protein 125, E3 ubiquitin protein ligase
RRAGB Ras-related GTP binding B
SAG S-antigen; retina and pineal gland (arrestin)
SCGB2A2 secretoglobin, family 2A, member 2
SEMA6D sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
SLC10A1 solute carrier family 10 (sodium/bile acid cotransporter), member 1
SLC16A4 solute carrier family 16, member 4
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
SLC7A9 solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9
SLN sarcolipin
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SNTA1 syntrophin, alpha 1
SPRR1B small proline-rich protein 1B
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SYNC syncoilin, intermediate filament protein
TBX3 T-box 3
TG thyroglobulin
TM4SF5 transmembrane 4 L six family member 5
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
TRIM68 tripartite motif containing 68
TSPAN9 tetraspanin 9
VASH2 vasohibin 2
VCPIP1 valosin containing protein (p97)/p47 complex interacting protein 1
VEGFC vascular endothelial growth factor C
VIM vimentin
WDR62 WD repeat domain 62
YIF1B Yip1 interacting factor homolog B (S. cerevisiae)
ZFP37 ZFP37 zinc finger protein
ZIC3 Zic family member 3
ZNF41 zinc finger protein 41
ZNF506 zinc finger protein 506
ZNF532 zinc finger protein 532
ZNF652 zinc finger protein 652
ZSWIM1 zinc finger, SWIM-type containing 1