proguanil-3505 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the proguanil-3505 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACACB acetyl-CoA carboxylase beta
ADAMTS7 ADAM metallopeptidase with thrombospondin type 1 motif, 7
ALCAM activated leukocyte cell adhesion molecule
ANG angiogenin, ribonuclease, RNase A family, 5
ANXA10 annexin A10
ARID3B AT rich interactive domain 3B (BRIGHT-like)
ATPAF2 ATP synthase mitochondrial F1 complex assembly factor 2
BLNK B-cell linker
C21ORF2 chromosome 21 open reading frame 2
C7ORF69 chromosome 7 open reading frame 69
C9ORF16 chromosome 9 open reading frame 16
CASP2 caspase 2, apoptosis-related cysteine peptidase
CCDC186 coiled-coil domain containing 186
CD58 CD58 molecule
CHERP calcium homeostasis endoplasmic reticulum protein
DSG3 desmoglein 3
EDRF1 erythroid differentiation regulatory factor 1
ELL2 elongation factor, RNA polymerase II, 2
EML2 echinoderm microtubule associated protein like 2
FAM63B family with sequence similarity 63, member B
FANCA Fanconi anemia, complementation group A
FGF6 fibroblast growth factor 6
FOXN3 forkhead box N3
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
GAL galanin/GMAP prepropeptide
GLDC glycine dehydrogenase (decarboxylating)
GLS glutaminase
GSN-AS1 GSN antisense RNA 1
GTF2A1 general transcription factor IIA, 1, 19/37kDa
GUCY1A2 guanylate cyclase 1, soluble, alpha 2
HFE hemochromatosis
HIC2 hypermethylated in cancer 2
HIST1H4E histone cluster 1, H4e
IFFO1 intermediate filament family orphan 1
IFT54 intraflagellar transport 54
IGHMBP2 immunoglobulin mu binding protein 2
IL11 interleukin 11
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
IZUMO4 IZUMO family member 4
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
LOC646934 golgin A6 family, member D pseudogene
MAOA monoamine oxidase A
MMRN2 multimerin 2
MRPL41 mitochondrial ribosomal protein L41
MTSS1L metastasis suppressor 1-like
NCOA2 nuclear receptor coactivator 2
NEB nebulin
NUDT7 nudix (nucleoside diphosphate linked moiety X)-type motif 7
NUP88 nucleoporin 88kDa
PCDHA5 protocadherin alpha 5
PCDHGA11 protocadherin gamma subfamily A, 11
PCSK6 proprotein convertase subtilisin/kexin type 6
PER2 period circadian clock 2
PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
PHEX phosphate regulating endopeptidase homolog, X-linked
PHF8 PHD finger protein 8
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PLD1 phospholipase D1, phosphatidylcholine-specific
PML promyelocytic leukemia
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PPP1R37 protein phosphatase 1, regulatory subunit 37
PSD3 pleckstrin and Sec7 domain containing 3
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2
RB1 retinoblastoma 1
RETN resistin
RMND5A required for meiotic nuclear division 5 homolog A (S. cerevisiae)
SATB2 SATB homeobox 2
SC5D sterol-C5-desaturase
SCN2B sodium channel, voltage gated, type II beta subunit
SDC2 syndecan 2
SERGEF secretion regulating guanine nucleotide exchange factor
SIRT4 sirtuin 4
SKIL SKI-like proto-oncogene
SLC35D1 solute carrier family 35 (UDP-GlcA/UDP-GalNAc transporter), member D1
SOS2 son of sevenless homolog 2 (Drosophila)
SPDEF SAM pointed domain containing ETS transcription factor
SPON2 spondin 2, extracellular matrix protein
STK17A serine/threonine kinase 17a
STRN striatin, calmodulin binding protein
STS steroid sulfatase (microsomal), isozyme S
SUN1 Sad1 and UNC84 domain containing 1
TBC1D2B TBC1 domain family, member 2B
TCP11L1 t-complex 11, testis-specific-like 1
TENM1 teneurin transmembrane protein 1
TEP1 telomerase-associated protein 1
THY1 Thy-1 cell surface antigen
TIMP4 TIMP metallopeptidase inhibitor 4
TLE4 transducin-like enhancer of split 4
TMCC2 transmembrane and coiled-coil domain family 2
TNFRSF14 tumor necrosis factor receptor superfamily, member 14
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
TPMT thiopurine S-methyltransferase
TRAC T cell receptor alpha constant
TRIM68 tripartite motif containing 68
UBA7 ubiquitin-like modifier activating enzyme 7
WSB1 WD repeat and SOCS box containing 1
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4
ZFX zinc finger protein, X-linked
ZNF235 zinc finger protein 235

decreased expression

Symbol Name
ABHD14A abhydrolase domain containing 14A
ADM adrenomedullin
ASPHD1 aspartate beta-hydroxylase domain containing 1
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
B4GALT2 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2
BATF basic leucine zipper transcription factor, ATF-like
BCORL1 BCL6 corepressor-like 1
C10ORF95 chromosome 10 open reading frame 95
C11ORF80 chromosome 11 open reading frame 80
C14ORF132 chromosome 14 open reading frame 132
C16ORF62 chromosome 16 open reading frame 62
C1QTNF3 C1q and tumor necrosis factor related protein 3
CASZ1 castor zinc finger 1
CBX7 chromobox homolog 7
CCDC85C coiled-coil domain containing 85C
CD302 CD302 molecule
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11
CLCF1 cardiotrophin-like cytokine factor 1
CLDN9 claudin 9
CLUHP3 clustered mitochondria (cluA/CLU1) homolog pseudogene 3
CNGB3 cyclic nucleotide gated channel beta 3
CST6 cystatin E/M
CXCR2 chemokine (C-X-C motif) receptor 2
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DAGLA diacylglycerol lipase, alpha
EDC4 enhancer of mRNA decapping 4
EFNA3 ephrin-A3
ELMO3 engulfment and cell motility 3
FAAH fatty acid amide hydrolase
FAM155B family with sequence similarity 155, member B
FBXL6 F-box and leucine-rich repeat protein 6
FDXR ferredoxin reductase
FER fer (fps/fes related) tyrosine kinase
FGF23 fibroblast growth factor 23
FOXN2 forkhead box N2
FSCN1 fascin actin-bundling protein 1
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GNAT2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled
HYI hydroxypyruvate isomerase (putative)
IRF1 interferon regulatory factor 1
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KCTD20 potassium channel tetramerization domain containing 20
KIAA0556 KIAA0556
KIAA0894 KIAA0894 protein
LIME1 Lck interacting transmembrane adaptor 1
LRRC61 leucine rich repeat containing 61
LY6D lymphocyte antigen 6 complex, locus D
LYRM9 LYR motif containing 9
LZTR1 leucine-zipper-like transcription regulator 1
MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2
MAPK12 mitogen-activated protein kinase 12
MBTPS2 membrane-bound transcription factor peptidase, site 2
MCC mutated in colorectal cancers
MT1H metallothionein 1H
MYL5 myosin, light chain 5, regulatory
NACA2 nascent polypeptide-associated complex alpha subunit 2
NES nestin
NPFFR1 neuropeptide FF receptor 1
NUP62CL nucleoporin 62kDa C-terminal like
OLFML2A olfactomedin-like 2A
PIBF1 progesterone immunomodulatory binding factor 1
PPFIA3 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3
PPT2 palmitoyl-protein thioesterase 2
PRSS22 protease, serine, 22
RAB11FIP5 RAB11 family interacting protein 5 (class I)
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
RASL11B RAS-like, family 11, member B
RASSF7 Ras association (RalGDS/AF-6) domain family (N-terminal) member 7
RUSC2 RUN and SH3 domain containing 2
SCHIP1 schwannomin interacting protein 1
SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
SIRT6 sirtuin 6
SKI SKI proto-oncogene
SKIV2L superkiller viralicidic activity 2-like (S. cerevisiae)
SLC12A7 solute carrier family 12 (potassium/chloride transporter), member 7
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4
SLC25A22 solute carrier family 25 (mitochondrial carrier: glutamate), member 22
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SLC44A1 solute carrier family 44 (choline transporter), member 1
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa
STARD5 StAR-related lipid transfer (START) domain containing 5
STK16 serine/threonine kinase 16
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1
TCP10 t-complex 10
TMEM53 transmembrane protein 53
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
UBXN6 UBX domain protein 6
VGF VGF nerve growth factor inducible
VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae)
VWA1 von Willebrand factor A domain containing 1
WDR18 WD repeat domain 18
WDR19 WD repeat domain 19
ZBED1 zinc finger, BED-type containing 1
ZNF37BP zinc finger protein 37B, pseudogene
ZNF787 zinc finger protein 787