promazine-4308 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the promazine-4308 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCA2 ATP-binding cassette, sub-family A (ABC1), member 2
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
AGRN agrin
AIM2 absent in melanoma 2
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
ATN1 atrophin 1
BCL3 B-cell CLL/lymphoma 3
BGN biglycan
BIRC3 baculoviral IAP repeat containing 3
BTF3P11 basic transcription factor 3 pseudogene 11
C1ORF116 chromosome 1 open reading frame 116
CACNG4 calcium channel, voltage-dependent, gamma subunit 4
CD207 CD207 molecule, langerin
CDH15 cadherin 15, type 1, M-cadherin (myotubule)
CDK13 cyclin-dependent kinase 13
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHRNB3 cholinergic receptor, nicotinic, beta 3 (neuronal)
CLEC11A C-type lectin domain family 11, member A
CLTA clathrin, light chain A
CNPPD1 cyclin Pas1/PHO80 domain containing 1
CPZ carboxypeptidase Z
CRTC1 CREB regulated transcription coactivator 1
CRYGC crystallin, gamma C
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT3 DNA-damage-inducible transcript 3
DENND3 DENN/MADD domain containing 3
DEPDC5 DEP domain containing 5
DMBT1 deleted in malignant brain tumors 1
EIF3F eukaryotic translation initiation factor 3, subunit F
ELAVL3 ELAV like neuron-specific RNA binding protein 3
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
ENG endoglin
EXD3 exonuclease 3'-5' domain containing 3
FAM189A2 family with sequence similarity 189, member A2
FOXRED2 FAD-dependent oxidoreductase domain containing 2
GJA9 gap junction protein, alpha 9, 59kDa
GPR182 G protein-coupled receptor 182
GYPB glycophorin B (MNS blood group)
GYPC glycophorin C (Gerbich blood group)
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HFE hemochromatosis
HMGA1 high mobility group AT-hook 1
HR hair growth associated
HSF1 heat shock transcription factor 1
HSPB6 heat shock protein, alpha-crystallin-related, B6
HTR1F 5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled
ICAM1 intercellular adhesion molecule 1
ICOSLG inducible T-cell co-stimulator ligand
IDS iduronate 2-sulfatase
IGL immunoglobulin lambda locus
INPP5J inositol polyphosphate-5-phosphatase J
JUND jun D proto-oncogene
KCNMB1 potassium channel subfamily M regulatory beta subunit 1
KLK7 kallikrein-related peptidase 7
KRT34 keratin 34, type I
LRCH4 leucine-rich repeats and calponin homology (CH) domain containing 4
LRP1 low density lipoprotein receptor-related protein 1
LTB4R leukotriene B4 receptor
MAFK v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K
MAP2K7 mitogen-activated protein kinase kinase 7
MED25 mediator complex subunit 25
MEF2D myocyte enhancer factor 2D
MUC8 mucin 8
MYL4 myosin, light chain 4, alkali; atrial, embryonic
NCOA3 nuclear receptor coactivator 3
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NPY2R neuropeptide Y receptor Y2
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PKD1 polycystic kidney disease 1 (autosomal dominant)
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTAFR platelet-activating factor receptor
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PXN paxillin
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1
REEP2 receptor accessory protein 2
RGS4 regulator of G-protein signaling 4
ROBO4 roundabout, axon guidance receptor, homolog 4 (Drosophila)
RPLP2 ribosomal protein, large, P2
SARM1 sterile alpha and TIR motif containing 1
SBNO2 strawberry notch homolog 2 (Drosophila)
SLC22A7 solute carrier family 22 (organic anion transporter), member 7
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6
SLC9A3R2 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SORBS3 sorbin and SH3 domain containing 3
SULT4A1 sulfotransferase family 4A, member 1
TBX6 T-box 6
TMEM176A transmembrane protein 176A
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRIM3 tripartite motif containing 3
TTC38 tetratricopeptide repeat domain 38
ZNF710 zinc finger protein 710

decreased expression

Symbol Name
AHR aryl hydrocarbon receptor
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
BCKDHA branched chain keto acid dehydrogenase E1, alpha polypeptide
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BRCC3 BRCA1/BRCA2-containing complex, subunit 3
BRIP1 BRCA1 interacting protein C-terminal helicase 1
C11ORF30 chromosome 11 open reading frame 30
C11ORF73 chromosome 11 open reading frame 73
C17ORF75 chromosome 17 open reading frame 75
CCBL1 cysteine conjugate-beta lyase, cytoplasmic
CCDC88A coiled-coil domain containing 88A
CDC7 cell division cycle 7
CEP97 centrosomal protein 97kDa
CHCHD7 coiled-coil-helix-coiled-coil-helix domain containing 7
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1
DEPDC1 DEP domain containing 1
E2F8 E2F transcription factor 8
EHF ets homologous factor
ELOVL4 ELOVL fatty acid elongase 4
ELOVL6 ELOVL fatty acid elongase 6
FBXO2 F-box protein 2
FKBPL FK506 binding protein like
FOXJ2 forkhead box J2
FPGT fucose-1-phosphate guanylyltransferase
GALK1 galactokinase 1
GLCE glucuronic acid epimerase
GLDC glycine dehydrogenase (decarboxylating)
GLTP glycolipid transfer protein
GPATCH3 G patch domain containing 3
GRWD1 glutamate-rich WD repeat containing 1
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HAS2 hyaluronan synthase 2
HIST1H1D histone cluster 1, H1d
HIST1H1E histone cluster 1, H1e
HIST1H4C histone cluster 1, H4c
HOXC8 homeobox C8
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFT81 intraflagellar transport 81
IMPACT impact RWD domain protein
INCENP inner centromere protein antigens 135/155kDa
KIAA1551 KIAA1551
KPNA5 karyopherin alpha 5 (importin alpha 6)
LRRC37A4P leucine rich repeat containing 37, member A4, pseudogene
MANSC1 MANSC domain containing 1
MATN3 matrilin 3
MGC12488
MRPL44 mitochondrial ribosomal protein L44
MTMR6 myotubularin related protein 6
MUM1 melanoma associated antigen (mutated) 1
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric
NAA38 N(alpha)-acetyltransferase 38, NatC auxiliary subunit
NDC80 NDC80 kinetochore complex component
NDP Norrie disease (pseudoglioma)
NFIX nuclear factor I/X (CCAAT-binding transcription factor)
NHLRC2 NHL repeat containing 2
NRTN neurturin
NUPL2 nucleoporin like 2
NUTF2 nuclear transport factor 2
OXR1 oxidation resistance 1
PALMD palmdelphin
PARPBP PARP1 binding protein
PCDHGB5 protocadherin gamma subfamily B, 5
PCF11 PCF11 cleavage and polyadenylation factor subunit
PPIP5K2 diphosphoinositol pentakisphosphate kinase 2
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
PRR14L proline rich 14-like
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
RBL1 retinoblastoma-like 1
RFX7 regulatory factor X, 7
RGS20 regulator of G-protein signaling 20
RHOBTB1 Rho-related BTB domain containing 1
RHOBTB2 Rho-related BTB domain containing 2
RPAP2 RNA polymerase II associated protein 2
SLC25A40 solute carrier family 25, member 40
SMAD5 SMAD family member 5
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SMU1 smu-1 suppressor of mec-8 and unc-52 homolog (C. elegans)
SNX24 sorting nexin 24
SOX9 SRY (sex determining region Y)-box 9
SPRYD7 SPRY domain containing 7
SRD5A3 steroid 5 alpha-reductase 3
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma)
TAF12 TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa
TAF13 TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor)
TIPRL TOR signaling pathway regulator
TMEM254 transmembrane protein 254
TTF2 transcription termination factor, RNA polymerase II
TUBA4B tubulin, alpha 4b
UBA2 ubiquitin-like modifier activating enzyme 2
WDR43 WD repeat domain 43
ZDHHC13 zinc finger, DHHC-type containing 13
ZNF137P zinc finger protein 137, pseudogene
ZNF184 zinc finger protein 184
ZNF329 zinc finger protein 329
ZNF528 zinc finger protein 528
ZNF76 zinc finger protein 76