promethazine-3100 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the promethazine-3100 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACTL8 actin-like 8
ADD2 adducin 2 (beta)
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
APOC4 apolipoprotein C-IV
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
B3GALNT1 beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group)
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
BAZ2A bromodomain adjacent to zinc finger domain, 2A
C11ORF16 chromosome 11 open reading frame 16
C19ORF73 chromosome 19 open reading frame 73
CACNA1I calcium channel, voltage-dependent, T type, alpha 1I subunit
CADM4 cell adhesion molecule 4
CAMTA1 calmodulin binding transcription activator 1
CARD14 caspase recruitment domain family, member 14
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2
CCDC85B coiled-coil domain containing 85B
CD40LG CD40 ligand
CD44 CD44 molecule (Indian blood group)
CLCA1 chloride channel accessory 1
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
CNGB3 cyclic nucleotide gated channel beta 3
COMT catechol-O-methyltransferase
COPE coatomer protein complex, subunit epsilon
CPED1 cadherin-like and PC-esterase domain containing 1
CPT1A carnitine palmitoyltransferase 1A (liver)
CREM cAMP responsive element modulator
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
DAPK3 death-associated protein kinase 3
DDN dendrin
DGCR8 DGCR8 microprocessor complex subunit
DMP1 dentin matrix acidic phosphoprotein 1
DUSP13 dual specificity phosphatase 13
EFNA3 ephrin-A3
EFR3B EFR3 homolog B (S. cerevisiae)
EGFR epidermal growth factor receptor
EML2 echinoderm microtubule associated protein like 2
EPHB2 EPH receptor B2
EPM2A epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)
FAM65B family with sequence similarity 65, member B
FHL3 four and a half LIM domains 3
FOSL2 FOS-like antigen 2
FSCN3 fascin actin-bundling protein 3, testicular
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
HRH2 histamine receptor H2
HTR1F 5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled
IGHMBP2 immunoglobulin mu binding protein 2
IL16 interleukin 16
IZUMO4 IZUMO family member 4
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KDSR 3-ketodihydrosphingosine reductase
KLF12 Kruppel-like factor 12
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LMNA lamin A/C
LTBP1 latent transforming growth factor beta binding protein 1
MAP4 microtubule-associated protein 4
MAPK11 mitogen-activated protein kinase 11
MC2R melanocortin 2 receptor (adrenocorticotropic hormone)
MIA melanoma inhibitory activity
MIIP migration and invasion inhibitory protein
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
MNMIP1 manchette microtubule inner protein 1
MRPS12 mitochondrial ribosomal protein S12
MUL1 mitochondrial E3 ubiquitin protein ligase 1
MYH10 myosin, heavy chain 10, non-muscle
MYO7A myosin VIIA
NEK1 NIMA-related kinase 1
NF2 neurofibromin 2 (merlin)
PAPPA pregnancy-associated plasma protein A, pappalysin 1
PAPPA2 pappalysin 2
PHYHIP phytanoyl-CoA 2-hydroxylase interacting protein
PIGQ phosphatidylinositol glycan anchor biosynthesis, class Q
PLA2G1B phospholipase A2, group IB (pancreas)
PLD1 phospholipase D1, phosphatidylcholine-specific
PPT2 palmitoyl-protein thioesterase 2
PRAMEF11 PRAME family member 11
RAMP1 receptor (G protein-coupled) activity modifying protein 1
SCIN scinderin
SCN5A sodium channel, voltage gated, type V alpha subunit
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SIRPA signal-regulatory protein alpha
SIRT3 sirtuin 3
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7
SLC25A22 solute carrier family 25 (mitochondrial carrier: glutamate), member 22
SLC9A5 solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5
SLCO1A2 solute carrier organic anion transporter family, member 1A2
SPAG8 sperm associated antigen 8
SPINK5 serine peptidase inhibitor, Kazal type 5
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
SUN1 Sad1 and UNC84 domain containing 1
THSD7A thrombospondin, type I, domain containing 7A
TRIP11 thyroid hormone receptor interactor 11
TTLL5 tubulin tyrosine ligase-like family member 5
TYRO3 TYRO3 protein tyrosine kinase
UPK1B uroplakin 1B
ZNF185 zinc finger protein 185 (LIM domain)
ZNF219 zinc finger protein 219
ZNF668 zinc finger protein 668

decreased expression

Symbol Name
A2M alpha-2-macroglobulin
AEN apoptosis enhancing nuclease
AKTIP AKT interacting protein
ARHGAP10 Rho GTPase activating protein 10
ASGR2 asialoglycoprotein receptor 2
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
BEND5 BEN domain containing 5
BEST1 bestrophin 1
BTBD3 BTB (POZ) domain containing 3
C2ORF44 chromosome 2 open reading frame 44
C5ORF45 chromosome 5 open reading frame 45
CCDC9 coiled-coil domain containing 9
CCRN4L CCR4 carbon catabolite repression 4-like (S. cerevisiae)
CD38 CD38 molecule
CDKL3 cyclin-dependent kinase-like 3
CEP97 centrosomal protein 97kDa
CHPF chondroitin polymerizing factor
CHRNA10 cholinergic receptor, nicotinic, alpha 10 (neuronal)
CHRNA9 cholinergic receptor, nicotinic, alpha 9 (neuronal)
CINP cyclin-dependent kinase 2 interacting protein
CLCN5 chloride channel, voltage-sensitive 5
CMTR1 cap methyltransferase 1
CRYL1 crystallin, lambda 1
DECR2 2,4-dienoyl CoA reductase 2, peroxisomal
DHRS3 dehydrogenase/reductase (SDR family) member 3
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha)
DVL1 dishevelled segment polarity protein 1
EDAR ectodysplasin A receptor
ELSPBP1 epididymal sperm binding protein 1
FAM189B family with sequence similarity 189, member B
FGGY FGGY carbohydrate kinase domain containing
FLJ21369 uncharacterized protein FLJ21369
FLT4 fms-related tyrosine kinase 4
FOXO4 forkhead box O4
GPR3 G protein-coupled receptor 3
GPRASP1 G protein-coupled receptor associated sorting protein 1
GTF2A1 general transcription factor IIA, 1, 19/37kDa
HAMP hepcidin antimicrobial peptide
HECTD3 HECT domain containing E3 ubiquitin protein ligase 3
HGSNAT heparan-alpha-glucosaminide N-acetyltransferase
HIST1H1B histone cluster 1, H1b
HIST1H2AE histone cluster 1, H2ae
HTR2B 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
INO80D INO80 complex subunit D
INPP5E inositol polyphosphate-5-phosphatase, 72 kDa
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
ITGB7 integrin, beta 7
KIAA0319L KIAA0319-like
KIAA0754 KIAA0754
KIF23 kinesin family member 23
KLHDC4 kelch domain containing 4
KPTN kaptin (actin binding protein)
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2
LPAR6 lysophosphatidic acid receptor 6
LRRK1 leucine-rich repeat kinase 1
MAP3K14 mitogen-activated protein kinase kinase kinase 14
METTL21B methyltransferase like 21B
MTG1 mitochondrial ribosome-associated GTPase 1
MXD3 MAX dimerization protein 3
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NAB2 NGFI-A binding protein 2 (EGR1 binding protein 2)
NACA2 nascent polypeptide-associated complex alpha subunit 2
NAG18 NAG18 mRNA
NOD1 nucleotide-binding oligomerization domain containing 1
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime
PERP PERP, TP53 apoptosis effector
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1
POM121 POM121 transmembrane nucleoporin
PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4
RAB17 RAB17, member RAS oncogene family
RABL6 RAB, member RAS oncogene family-like 6
RFXAP regulatory factor X-associated protein
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1
RPA4 replication protein A4, 30kDa
RPL13P5 ribosomal protein L13 pseudogene 5
RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2
S1PR4 sphingosine-1-phosphate receptor 4
SCAMP4 secretory carrier membrane protein 4
SCN10A sodium channel, voltage gated, type X alpha subunit
SCRN3 secernin 3
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SPTLC3 serine palmitoyltransferase, long chain base subunit 3
STX1A syntaxin 1A (brain)
THAP10 THAP domain containing 10
TIGD6 tigger transposable element derived 6
TIMP2 TIMP metallopeptidase inhibitor 2
TMEM120B transmembrane protein 120B
TMEM140 transmembrane protein 140
TMEM19 transmembrane protein 19
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TNFRSF14 tumor necrosis factor receptor superfamily, member 14
TPCN1 two pore segment channel 1
TRPV1 transient receptor potential cation channel, subfamily V, member 1
UBQLN4 ubiquilin 4
UPP1 uridine phosphorylase 1
XKR8 XK, Kell blood group complex subunit-related family, member 8
ZC3H12A zinc finger CCCH-type containing 12A
ZDHHC24 zinc finger, DHHC-type containing 24
ZNF428 zinc finger protein 428