pronucleus Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description The nucleus of either the ovum or the spermatozoon following fertilization. Thus, in the fertilized ovum, there are two pronuclei, one originating from the ovum, the other from the spermatozoon that brought about fertilization; they approach each other, but do not fuse until just before the first cleavage, when each pronucleus loses its membrane to release its contents. (Gene Ontology, GO_0045120)
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246 proteins co-occuring with the pronucleus cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
PLCZ1 phospholipase C, zeta 1 1.6071
H3F3B H3 histone, family 3B (H3.3B) 1.11174
H3F3A H3 histone, family 3A 1.11174
WBP2NL WBP2 N-terminal like 1.10053
CDK1 cyclin-dependent kinase 1 1.08272
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone) 1.066
HIST2H3PS2 histone cluster 2, H3, pseudogene 2 1.04833
CCNB1 cyclin B1 1.01585
TET3 tet methylcytosine dioxygenase 3 0.993183
ACTB actin, beta 0.964549
ACTG1 actin gamma 1 0.932187
COLEC12 collectin sub-family member 12 0.929833
IFI30 interferon, gamma-inducible protein 30 0.902281
CPXM2 carboxypeptidase X (M14 family), member 2 0.85342
C19ORF26 chromosome 19 open reading frame 26 0.84791
HIST1H4K histone cluster 1, H4k 0.844696
HIST1H4J histone cluster 1, H4j 0.844696
HIST1H4F histone cluster 1, H4f 0.844696
HIST2H4A histone cluster 2, H4a 0.844696
HIST1H4E histone cluster 1, H4e 0.844696
HIST1H4I histone cluster 1, H4i 0.844696
HIST1H4A histone cluster 1, H4a 0.844696
HIST1H4B histone cluster 1, H4b 0.844696
HIST1H4C histone cluster 1, H4c 0.844696
HIST1H4H histone cluster 1, H4h 0.844696
HIST1H4D histone cluster 1, H4d 0.844696
HIST2H4B histone cluster 2, H4b 0.844696
HIST1H4L histone cluster 1, H4l 0.844237
HIST4H4 histone cluster 4, H4 0.844237
ALB albumin 0.800187
DPPA2 developmental pluripotency associated 2 0.790106
HSPA1B heat shock 70kDa protein 1B 0.785986
PSG11 pregnancy specific beta-1-glycoprotein 11 0.763617
PRM1 protamine 1 0.754983
HIST2H2AC histone cluster 2, H2ac 0.737813
HIST2H2AA4 histone cluster 2, H2aa4 0.737363
HIST2H2AA3 histone cluster 2, H2aa3 0.737363
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.729284
PSG6 pregnancy specific beta-1-glycoprotein 6 0.719906
NLRP9 NLR family, pyrin domain containing 9 0.685517
TUBA1A tubulin, alpha 1a 0.684644
NPB neuropeptide B 0.668126
DPPA3 developmental pluripotency associated 3 0.6638
LEMD1 LEM domain containing 1 0.663368
HSPA1A heat shock 70kDa protein 1A 0.641858
BSPRY B-box and SPRY domain containing 0.638434
GGTA1P glycoprotein, alpha-galactosyltransferase 1 pseudogene 0.629465
TSPO translocator protein (18kDa) 0.625206
NUMA1 nuclear mitotic apparatus protein 1 0.615013
PORCN porcupine homolog (Drosophila) 0.59896
BPIFA1 BPI fold containing family A, member 1 0.598538
NANOG Nanog homeobox 0.588456
FOXE1 forkhead box E1 0.584686
CCT6B chaperonin containing TCP1, subunit 6B (zeta 2) 0.576747
FBLL1 fibrillarin-like 1 0.57008
AGO3 argonaute RISC catalytic component 3 0.561772
RAD51D RAD51 paralog D 0.5597
H1FX H1 histone family, member X 0.552664
WBP2 WW domain binding protein 2 0.551838
H2AFX H2A histone family, member X 0.539472
PHF7 PHD finger protein 7 0.53906
TDG thymine-DNA glycosylase 0.512862
LALBA lactalbumin, alpha- 0.50879
HSF2 heat shock transcription factor 2 0.505131
POU5F1 POU class 5 homeobox 1 0.49418
ZP2 zona pellucida glycoprotein 2 (sperm receptor) 0.487307
PSG2 pregnancy specific beta-1-glycoprotein 2 0.484886
LBR lamin B receptor 0.484483
PSG8 pregnancy specific beta-1-glycoprotein 8 0.476831
F9 coagulation factor IX 0.474822
SSFA2 sperm specific antigen 2 0.472813
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 0.471609
TXNDC8 thioredoxin domain containing 8 (spermatozoa) 0.4676
ACSM2A acyl-CoA synthetase medium-chain family member 2A 0.466399
MBD3L2 methyl-CpG binding domain protein 3-like 2 0.458803
PSG1 pregnancy specific beta-1-glycoprotein 1 0.454418
CSN2 casein beta 0.452427
MT1A metallothionein 1A 0.4425
DPPA5 developmental pluripotency associated 5 0.4425
FIGLA folliculogenesis specific basic helix-loop-helix 0.435775
CCNB2 cyclin B2 0.43538
POU5F1B POU class 5 homeobox 1B 0.426318
USP47 ubiquitin specific peptidase 47 0.421604
MAPK15 mitogen-activated protein kinase 15 0.413773
OVGP1 oviductal glycoprotein 1, 120kDa 0.41182
GLB1 galactosidase, beta 1 0.41143
WEE2 WEE1 homolog 2 (S. pombe) 0.40675
TOP2B topoisomerase (DNA) II beta 180kDa 0.403637
HILS1 histone linker H1 domain, spermatid-specific 1, pseudogene 0.401304
ZFP57 ZFP57 zinc finger protein 0.400527
PSG9 pregnancy specific beta-1-glycoprotein 9 0.400527
PSG3 pregnancy specific beta-1-glycoprotein 3 0.397035
CSN1S1 casein alpha s1 0.392001
MED29 mediator complex subunit 29 0.390068
HSF1 heat shock transcription factor 1 0.389682
ISPD isoprenoid synthase domain containing 0.388137
MBD3L1 methyl-CpG binding domain protein 3-like 1 0.388137
PLK2 polo-like kinase 2 0.381969
EPHA8 EPH receptor A8 0.380429
ZP3 zona pellucida glycoprotein 3 (sperm receptor) 0.37966
CDK2 cyclin-dependent kinase 2 0.375434
KRT71 keratin 71, type II 0.373899
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.367771
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) 0.364331
CLNK cytokine-dependent hematopoietic cell linker 0.362422
LMNA lamin A/C 0.357847
SUZ12 SUZ12 polycomb repressive complex 2 subunit 0.355183
NUCLEOLIN nucleolin multifunctional protein 0.351002
DSE dermatan sulfate epimerase 0.344556
PPP1R12C protein phosphatase 1, regulatory subunit 12C 0.343421
TYR tyrosinase 0.336996
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.336241
MAP2K2 mitogen-activated protein kinase kinase 2 0.335487
DUSP16 dual specificity phosphatase 16 0.33511
BCL2L10 BCL2-like 10 (apoptosis facilitator) 0.334356
MSH6 mutS homolog 6 0.331342
WDR83 WD repeat domain 83 0.32195
IGF2 insulin-like growth factor 2 0.319328
GPI glucose-6-phosphate isomerase 0.314091
HIRA histone cell cycle regulator 0.313344
OR3A1 olfactory receptor, family 3, subfamily A, member 1 0.310358
FGF4 fibroblast growth factor 4 0.306632
CYP3A7 cytochrome P450, family 3, subfamily A, polypeptide 7 0.304027
AVIL advillin 0.298826
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin) 0.296601
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related) 0.295489
SRI sorcin 0.292527
NLRP5 NLR family, pyrin domain containing 5 0.291787
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 0.287721
OR10T2 olfactory receptor, family 10, subfamily T, member 2 0.284769
BMP10 bone morphogenetic protein 10 0.280716
LRMP lymphoid-restricted membrane protein 0.279612
CHRFAM7A CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion 0.278877
SNRPN small nuclear ribonucleoprotein polypeptide N 0.278141
PRM2 protamine 2 0.277406
HOXB8 homeobox B8 0.276304
CEACAM3 carcinoembryonic antigen-related cell adhesion molecule 3 0.271533
CSH1 chorionic somatomammotropin hormone 1 (placental lactogen) 0.268969
TOP1 topoisomerase (DNA) I 0.268603
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 0.266408
SOD2 superoxide dismutase 2, mitochondrial 0.266042
PLK1 polo-like kinase 1 0.264946
PLB1 phospholipase B1 0.264946
LIG3 ligase III, DNA, ATP-dependent 0.262755
BPIFA2 BPI fold containing family A, member 2 0.262025
CDV3 CDV3 homolog (mouse) 0.26166
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.260202
CALM3 calmodulin 3 (phosphorylase kinase, delta) 0.260202
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.259837
FYN FYN proto-oncogene, Src family tyrosine kinase 0.256925
CFAP74 cilia and flagella associated protein 74 0.25438
H2AFB1 H2A histone family, member B1 0.253291
DPT dermatopontin 0.252927
TICAM2 toll-like receptor adaptor molecule 2 0.252564
CSH2 chorionic somatomammotropin hormone 2 0.251839
NNAT neuronatin 0.251114
H2AFB2 H2A histone family, member B2 0.250026
ADAR adenosine deaminase, RNA-specific 0.250026
SLC4A8 solute carrier family 4, sodium bicarbonate cotransporter, member 8 0.249664
HDAC1 histone deacetylase 1 0.248578
HSPE1 heat shock 10kDa protein 1 0.246769
CDC25B cell division cycle 25B 0.246769
GH1 growth hormone 1 0.243879
EHMT2 euchromatic histone-lysine N-methyltransferase 2 0.242437
ZAR1 zygote arrest 1 0.240636
MID2 midline 2 0.240276
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1 0.238119
H1FOO H1 histone family, member O, oocyte-specific 0.233817
ZFR zinc finger RNA binding protein 0.233459
CDC25C cell division cycle 25C 0.232744
AKAP8 A kinase (PRKA) anchor protein 8 0.231672
DNTT DNA nucleotidylexotransferase 0.231672
GBX2 gastrulation brain homeobox 2 0.230958
NLRP7 NLR family, pyrin domain containing 7 0.229176
RHOBTB2 Rho-related BTB domain containing 2 0.22385
GREM1 gremlin 1, DAN family BMP antagonist 0.223497
CRYAA crystallin, alpha A 0.219969
SRY sex determining region Y 0.219617
TXN thioredoxin 0.219265
NPM2 nucleophosmin/nucleoplasmin 2 0.219265
SLCO2A1 solute carrier organic anion transporter family, member 2A1 0.215063
SPIN1 spindlin 1 0.214366
SLBP stem-loop binding protein 0.213669
EIF4A2 eukaryotic translation initiation factor 4A2 0.211587
CDX2 caudal type homeobox 2 0.208481
SMCP sperm mitochondria-associated cysteine-rich protein 0.204718
NLRP2 NLR family, pyrin domain containing 2 0.203361
ANAPC4 anaphase promoting complex subunit 4 0.199993
UMOD uromodulin 0.199659
ITGB5 integrin, beta 5 0.195681
INS insulin 0.193394
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.192746
SIX4 SIX homeobox 4 0.187646
PDCD6IP programmed cell death 6 interacting protein 0.187333
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta 0.187333
COIL coilin 0.186087
ACVR2B activin A receptor, type IIB 0.183935
IGF1 insulin-like growth factor 1 (somatomedin C) 0.18093
PSG5 pregnancy specific beta-1-glycoprotein 5 0.178011
TBP TATA box binding protein 0.17528
PSAT1 phosphoserine aminotransferase 1 0.175188
RAG1 recombination activating gene 1 0.173273
RBM3 RNA binding motif (RNP1, RRM) protein 3 0.173273
CXCL14 chemokine (C-X-C motif) ligand 14 0.173273
CYP21A2 cytochrome P450, family 21, subfamily A, polypeptide 2 0.172735
ELOVL4 ELOVL fatty acid elongase 4 0.171149
CD46 CD46 molecule, complement regulatory protein 0.170114
ECM1 extracellular matrix protein 1 0.169859
CS citrate synthase 0.169859
TAF1L TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like 0.168349
PLAG1 pleiomorphic adenoma gene 1 0.16342
PDCD5 programmed cell death 5 0.16298
CXCL3 chemokine (C-X-C motif) ligand 3 0.161484
POLI polymerase (DNA directed) iota 0.159074
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.15776
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 0.151206
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 0.150877
PARD6A par-6 family cell polarity regulator alpha 0.147177
WDR20 WD repeat domain 20 0.140385
ERG v-ets avian erythroblastosis virus E26 oncogene homolog 0.139186
DSPP dentin sialophosphoprotein 0.138208
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 0.137286
TACSTD2 tumor-associated calcium signal transducer 2 0.137136
DNMT3L DNA (cytosine-5-)-methyltransferase 3-like 0.136511
OR10A4 olfactory receptor, family 10, subfamily A, member 4 0.134682
SETDB1 SET domain, bifurcated 1 0.13441
TNP2 transition protein 2 (during histone to protamine replacement) 0.134131
ZP4 zona pellucida glycoprotein 4 0.133604
LDHB lactate dehydrogenase B 0.133468
LIG1 ligase I, DNA, ATP-dependent 0.133149
KIF5B kinesin family member 5B 0.133035
G6PD glucose-6-phosphate dehydrogenase 0.132583
PRIM1 primase, DNA, polypeptide 1 (49kDa) 0.132538
CHD1 chromodomain helicase DNA binding protein 1 0.132418
CENPA centromere protein A 0.132111
FUT3 fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group) 0.131617
PGRMC1 progesterone receptor membrane component 1 0.131403
RAN RAN, member RAS oncogene family 0.130556
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta 0.130375
STAT4 signal transducer and activator of transcription 4 0.130283
CENPB centromere protein B, 80kDa 0.130247
SPAG9 sperm associated antigen 9 0.129737
LIG4 ligase IV, DNA, ATP-dependent 0.129543
RGPD3 RANBP2-like and GRIP domain containing 3 0.129123
PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent) 0.128517
DLK1 delta-like 1 homolog (Drosophila) 0.128168