propafenone-1722 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the propafenone-1722 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase
AFF2 AF4/FMR2 family, member 2
AKAP8L A kinase (PRKA) anchor protein 8-like
AMT aminomethyltransferase
APLP2 amyloid beta (A4) precursor-like protein 2
ATP10B ATPase, class V, type 10B
BBC3 BCL2 binding component 3
BPIFA1 BPI fold containing family A, member 1
C1QTNF3 C1q and tumor necrosis factor related protein 3
C1QTNF9B-AS1 C1QTNF9B antisense RNA 1
C2CD2L C2CD2-like
CA5BP1 carbonic anhydrase VB pseudogene 1
CACNG4 calcium channel, voltage-dependent, gamma subunit 4
CAPN10 calpain 10
CD70 CD70 molecule
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
CDC5L cell division cycle 5-like
CDS2 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2
CELA3A chymotrypsin-like elastase family, member 3A
CIDEC cell death-inducing DFFA-like effector c
CIITA class II, major histocompatibility complex, transactivator
CLPTM1 cleft lip and palate associated transmembrane protein 1
COPS7B COP9 signalosome subunit 7B
CROT carnitine O-octanoyltransferase
CXCR3 chemokine (C-X-C motif) receptor 3
CYLD cylindromatosis (turban tumor syndrome)
DEF8 differentially expressed in FDCP 8 homolog (mouse)
DPP6 dipeptidyl-peptidase 6
DUS2 dihydrouridine synthase 2
EMC1 ER membrane protein complex subunit 1
EPB41L5 erythrocyte membrane protein band 4.1 like 5
EPM2A epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)
F12 coagulation factor XII (Hageman factor)
FAM214B family with sequence similarity 214, member B
FAM66D family with sequence similarity 66, member D
FAS Fas cell surface death receptor
FBXO42 F-box protein 42
FEM1C fem-1 homolog c (C. elegans)
FKBP6 FK506 binding protein 6, 36kDa
GFOD2 glucose-fructose oxidoreductase domain containing 2
GGA2 golgi-associated, gamma adaptin ear containing, ARF binding protein 2
GJD2 gap junction protein, delta 2, 36kDa
GPATCH3 G patch domain containing 3
HDAC11 histone deacetylase 11
HEXA hexosaminidase A (alpha polypeptide)
HIF1AN hypoxia inducible factor 1, alpha subunit inhibitor
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KIAA1549L KIAA1549-like
KLHL18 kelch-like family member 18
KLHL35 kelch-like family member 35
LENEP lens epithelial protein
LLGL1 lethal giant larvae homolog 1 (Drosophila)
LMF2 lipase maturation factor 2
LRRC41 leucine rich repeat containing 41
LZTS3 leucine zipper, putative tumor suppressor family member 3
MAPK10 mitogen-activated protein kinase 10
MFAP5 microfibrillar associated protein 5
MINK1 misshapen-like kinase 1
MMP19 matrix metallopeptidase 19
MOB3B MOB kinase activator 3B
MPPED1 metallophosphoesterase domain containing 1
MST1 macrophage stimulating 1
MTHFS 5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase)
NOV nephroblastoma overexpressed
NPFFR1 neuropeptide FF receptor 1
NUDT7 nudix (nucleoside diphosphate linked moiety X)-type motif 7
OCRL oculocerebrorenal syndrome of Lowe
OLFM1 olfactomedin 1
PARD3 par-3 family cell polarity regulator
PBX2 pre-B-cell leukemia homeobox 2
PCDH7 protocadherin 7
PCGF2 polycomb group ring finger 2
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PPME1 protein phosphatase methylesterase 1
PSPN persephin
PUS7L pseudouridylate synthase 7 homolog (S. cerevisiae)-like
RBM19 RNA binding motif protein 19
RGS3 regulator of G-protein signaling 3
RGSL1 regulator of G-protein signaling like 1
SGSH N-sulfoglucosamine sulfohydrolase
SIRT5 sirtuin 5
SLC1A7 solute carrier family 1 (glutamate transporter), member 7
SMG7 SMG7 nonsense mediated mRNA decay factor
TBX6 T-box 6
TEX261 testis expressed 261
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TM7SF2 transmembrane 7 superfamily member 2
TMEM127 transmembrane protein 127
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TP53I3 tumor protein p53 inducible protein 3
TTC3 tetratricopeptide repeat domain 3
WDR13 WD repeat domain 13
WDR61 WD repeat domain 61
WTAP Wilms tumor 1 associated protein
ZC3H7B zinc finger CCCH-type containing 7B
ZFYVE9 zinc finger, FYVE domain containing 9
ZNF142 zinc finger protein 142
ZNF248 zinc finger protein 248
ZNF518A zinc finger protein 518A

decreased expression

Symbol Name
ACO1 aconitase 1, soluble
ACP6 acid phosphatase 6, lysophosphatidic
ADRB2 adrenoceptor beta 2, surface
ANAPC15 anaphase promoting complex subunit 15
ANKRA2 ankyrin repeat, family A (RFXANK-like), 2
ANKRD36B ankyrin repeat domain 36B
ARHGEF10L Rho guanine nucleotide exchange factor (GEF) 10-like
ARL5A ADP-ribosylation factor-like 5A
ASB13 ankyrin repeat and SOCS box containing 13
ATAD2B ATPase family, AAA domain containing 2B
C5ORF15 chromosome 5 open reading frame 15
CARHSP1 calcium regulated heat stable protein 1, 24kDa
CD82 CD82 molecule
CDCA3 cell division cycle associated 3
CFL1 cofilin 1 (non-muscle)
CLDND1 claudin domain containing 1
CLK1 CDC-like kinase 1
COMMD8 COMM domain containing 8
CSF3R colony stimulating factor 3 receptor (granulocyte)
DCAF16 DDB1 and CUL4 associated factor 16
DCAF6 DDB1 and CUL4 associated factor 6
DCTN6 dynactin 6
DENND4A DENN/MADD domain containing 4A
DONSON downstream neighbor of SON
DYNC1I2 dynein, cytoplasmic 1, intermediate chain 2
DYNLL1 dynein, light chain, LC8-type 1
ERF Ets2 repressor factor
FAM114A1 family with sequence similarity 114, member A1
FAM188A family with sequence similarity 188, member A
FAM3C family with sequence similarity 3, member C
FAM50B family with sequence similarity 50, member B
FBXO5 F-box protein 5
FTH1P5 ferritin, heavy polypeptide 1 pseudogene 5
GDAP2 ganglioside induced differentiation associated protein 2
GMPS guanine monphosphate synthase
GTF2A2 general transcription factor IIA, 2, 12kDa
GTF2F2 general transcription factor IIF, polypeptide 2, 30kDa
H2BFS H2B histone family, member S (pseudogene)
HCAR3 hydroxycarboxylic acid receptor 3
HDAC4 histone deacetylase 4
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
HIST1H2BF histone cluster 1, H2bf
HJURP Holliday junction recognition protein
HMG20A high mobility group 20A
ICE2 interactor of little elongation complex ELL subunit 2
KDM5C lysine (K)-specific demethylase 5C
LPGAT1 lysophosphatidylglycerol acyltransferase 1
LRIF1 ligand dependent nuclear receptor interacting factor 1
MAGEF1 melanoma antigen family F1
MED17 mediator complex subunit 17
MED4 mediator complex subunit 4
MRPL28 mitochondrial ribosomal protein L28
MRPL33 mitochondrial ribosomal protein L33
MT1HL1 metallothionein 1H-like 1
MTMR6 myotubularin related protein 6
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric
NQO2 NAD(P)H dehydrogenase, quinone 2
NRIP3 nuclear receptor interacting protein 3
NT5DC3 5'-nucleotidase domain containing 3
NUBP2 nucleotide binding protein 2
OVGP1 oviductal glycoprotein 1, 120kDa
PAGR1 PAXIP1 associated glutamate-rich protein 1
PAQR3 progestin and adipoQ receptor family member III
PEX12 peroxisomal biogenesis factor 12
PLCD1 phospholipase C, delta 1
POTEKP POTE ankyrin domain family, member K, pseudogene
PPM1G protein phosphatase, Mg2+/Mn2+ dependent, 1G
RALA v-ral simian leukemia viral oncogene homolog A (ras related)
RIN1 Ras and Rab interactor 1
RSL24D1 ribosomal L24 domain containing 1
SEPW1 selenoprotein W, 1
SERPINB10 serpin peptidase inhibitor, clade B (ovalbumin), member 10
SKA1 spindle and kinetochore associated complex subunit 1
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC25A28 solute carrier family 25 (mitochondrial iron transporter), member 28
SLC25A40 solute carrier family 25, member 40
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SNRNP35 small nuclear ribonucleoprotein 35kDa (U11/U12)
STK26 serine/threonine protein kinase 26
STXBP3 syntaxin binding protein 3
TAF12 TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa
TAF5 TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa
TEX30 testis expressed 30
TIMM10B translocase of inner mitochondrial membrane 10 homolog B (yeast)
TINF2 TERF1 (TRF1)-interacting nuclear factor 2
TJP2 tight junction protein 2
TMA16 translation machinery associated 16 homolog (S. cerevisiae)
TMA7 translation machinery associated 7 homolog (S. cerevisiae)
TRAPPC11 trafficking protein particle complex 11
TRIM8 tripartite motif containing 8
TSPAN32 tetraspanin 32
TSR2 TSR2, 20S rRNA accumulation, homolog (S. cerevisiae)
TVP23B trans-golgi network vesicle protein 23 homolog B (S. cerevisiae)
TXLNA taxilin alpha
VCPKMT valosin containing protein lysine (K) methyltransferase
ZNF140 zinc finger protein 140
ZNF432 zinc finger protein 432
ZNF652 zinc finger protein 652
ZNHIT1 zinc finger, HIT-type containing 1