propafenone-6336 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

200 genes differentially expressed following the propafenone-6336 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCC9 ATP-binding cassette, sub-family C (CFTR/MRP), member 9
ADAM22 ADAM metallopeptidase domain 22
ADGRL1 adhesion G protein-coupled receptor L1
ALDH1L1 aldehyde dehydrogenase 1 family, member L1
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
AQP7 aquaporin 7
ASPHD1 aspartate beta-hydroxylase domain containing 1
B9D2 B9 protein domain 2
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C1QL1 complement component 1, q subcomponent-like 1
CABYR calcium binding tyrosine-(Y)-phosphorylation regulated
CACNG4 calcium channel, voltage-dependent, gamma subunit 4
CALD1 caldesmon 1
CASZ1 castor zinc finger 1
CCL27 chemokine (C-C motif) ligand 27
CCNO cyclin O
CD101 CD101 molecule
CFHR5 complement factor H-related 5
CHRNA9 cholinergic receptor, nicotinic, alpha 9 (neuronal)
CLPS colipase, pancreatic
CNTNAP2 contactin associated protein-like 2
COPA coatomer protein complex, subunit alpha
CRTAC1 cartilage acidic protein 1
CSF1R colony stimulating factor 1 receptor
CUZD1 CUB and zona pellucida-like domains 1
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase)
DENND3 DENN/MADD domain containing 3
DST dystonin
DTNA dystrobrevin, alpha
DYRK2 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
EPB41L4B erythrocyte membrane protein band 4.1 like 4B
FGF1 fibroblast growth factor 1 (acidic)
FOSL2 FOS-like antigen 2
FOXD2 forkhead box D2
GABARAPL1 GABA(A) receptor-associated protein like 1
GABARAPL3 GABA(A) receptors associated protein like 3, pseudogene
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
HAL histidine ammonia-lyase
HCFC1 host cell factor C1
HMOX1 heme oxygenase 1
HOXB5 homeobox B5
HPS1 Hermansky-Pudlak syndrome 1
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HTR7P1 5-hydroxytryptamine (serotonin) receptor 7 pseudogene 1
IFT122 intraflagellar transport 122
IKZF5 IKAROS family zinc finger 5 (Pegasus)
INPP5B inositol polyphosphate-5-phosphatase, 75kDa
KLF13 Kruppel-like factor 13
KRT33A keratin 33A, type I
KRT8P12 keratin 8 pseudogene 12
LINC00216 long intergenic non-protein coding RNA 216
MARK4 MAP/microtubule affinity-regulating kinase 4
MXD4 MAX dimerization protein 4
NF2 neurofibromin 2 (merlin)
NUPR1 nuclear protein, transcriptional regulator, 1
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OLFML3 olfactomedin-like 3
OSBPL10 oxysterol binding protein-like 10
OSGIN2 oxidative stress induced growth inhibitor family member 2
PAFAH2 platelet-activating factor acetylhydrolase 2, 40kDa
PCOLCE procollagen C-endopeptidase enhancer
PLIN2 perilipin 2
PML promyelocytic leukemia
PPP2R2B protein phosphatase 2, regulatory subunit B, beta
PRDX2 peroxiredoxin 2
PSEN2 presenilin 2
PTPRH protein tyrosine phosphatase, receptor type, H
PURA purine-rich element binding protein A
RGS7 regulator of G-protein signaling 7
RSPH14 radial spoke head 14 homolog (Chlamydomonas)
S100A13 S100 calcium binding protein A13
SARM1 sterile alpha and TIR motif containing 1
SCIN scinderin
SH2D3A SH2 domain containing 3A
SIRPB1 signal-regulatory protein beta 1
SLC15A1 solute carrier family 15 (oligopeptide transporter), member 1
SLC19A1 solute carrier family 19 (folate transporter), member 1
SLC1A7 solute carrier family 1 (glutamate transporter), member 7
SLC48A1 solute carrier family 48 (heme transporter), member 1
SRD5A3 steroid 5 alpha-reductase 3
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
SWAP70 SWAP switching B-cell complex 70kDa subunit
SYNDIG1 synapse differentiation inducing 1
SYNJ2 synaptojanin 2
TCP11L1 t-complex 11, testis-specific-like 1
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TGFB2 transforming growth factor, beta 2
TGFBI transforming growth factor, beta-induced, 68kDa
TRIM2 tripartite motif containing 2
TSSK2 testis-specific serine kinase 2
UBQLN4 ubiquilin 4
UNC13A unc-13 homolog A (C. elegans)
URB1 URB1 ribosome biogenesis 1 homolog (S. cerevisiae)
UROD uroporphyrinogen decarboxylase
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2)
WSB1 WD repeat and SOCS box containing 1
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase

decreased expression

Symbol Name
ADGRG2 adhesion G protein-coupled receptor G2
APLP1 amyloid beta (A4) precursor-like protein 1
BCL2A1 BCL2-related protein A1
C1ORF159 chromosome 1 open reading frame 159
CDH3 cadherin 3, type 1, P-cadherin (placental)
CLDN11 claudin 11
CLEC2B C-type lectin domain family 2, member B
CLIP4 CAP-GLY domain containing linker protein family, member 4
CNN2 calponin 2
COLGALT2 collagen beta(1-O)galactosyltransferase 2
COPS7B COP9 signalosome subunit 7B
CXORF56 chromosome X open reading frame 56
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6
DHX38 DEAH (Asp-Glu-Ala-His) box polypeptide 38
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJC22 DnaJ (Hsp40) homolog, subfamily C, member 22
ERN2 endoplasmic reticulum to nucleus signaling 2
FAM86C1 family with sequence similarity 86, member C1
FER fer (fps/fes related) tyrosine kinase
FUZ fuzzy planar cell polarity protein
GALE UDP-galactose-4-epimerase
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14
GPR87 G protein-coupled receptor 87
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HIST1H1D histone cluster 1, H1d
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1
HOXA4 homeobox A4
HOXC4 homeobox C4
HSPA2 heat shock 70kDa protein 2
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IL4R interleukin 4 receptor
IPPK inositol 1,3,4,5,6-pentakisphosphate 2-kinase
IREB2 iron-responsive element binding protein 2
KCNMB3 potassium channel subfamily M regulatory beta subunit 3
LYPLA2P1 lysophospholipase II pseudogene 1
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G
MAPK3 mitogen-activated protein kinase 3
MBIP MAP3K12 binding inhibitory protein 1
MBTPS2 membrane-bound transcription factor peptidase, site 2
MCRS1 microspherule protein 1
MICALL2 MICAL-like 2
MPDU1 mannose-P-dolichol utilization defect 1
MRPS27 mitochondrial ribosomal protein S27
MTERF4 mitochondrial transcription termination factor 4
MTG1 mitochondrial ribosome-associated GTPase 1
N6AMT1 N-6 adenine-specific DNA methyltransferase 1 (putative)
NXPE3 neurexophilin and PC-esterase domain family, member 3
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
ORAI3 ORAI calcium release-activated calcium modulator 3
PALMD palmdelphin
PCSK7 proprotein convertase subtilisin/kexin type 7
PCYT2 phosphate cytidylyltransferase 2, ethanolamine
PHKG2 phosphorylase kinase, gamma 2 (testis)
PIGL phosphatidylinositol glycan anchor biosynthesis, class L
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
POMT2 protein-O-mannosyltransferase 2
PRKCD protein kinase C, delta
PRMT7 protein arginine methyltransferase 7
PRPH peripherin
PTCD2 pentatricopeptide repeat domain 2
PTDSS2 phosphatidylserine synthase 2
QTRT1 queuine tRNA-ribosyltransferase 1
RANBP17 RAN binding protein 17
RBM14 RNA binding motif protein 14
RHBDF2 rhomboid 5 homolog 2 (Drosophila)
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4
SDC3 syndecan 3
SLC16A10 solute carrier family 16 (aromatic amino acid transporter), member 10
SLC46A3 solute carrier family 46, member 3
SMG9 SMG9 nonsense mediated mRNA decay factor
SMU1 smu-1 suppressor of mec-8 and unc-52 homolog (C. elegans)
SND1-IT1 SND1 intronic transcript 1
SP140L SP140 nuclear body protein-like
SPAG4 sperm associated antigen 4
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1
STAG3 stromal antigen 3
SUGP1 SURP and G patch domain containing 1
TBL3 transducin (beta)-like 3
TCTN2 tectonic family member 2
TFF2 trefoil factor 2
TGFB3 transforming growth factor, beta 3
TMEM8B transmembrane protein 8B
TPRA1 transmembrane protein, adipocyte asscociated 1
TRAPPC11 trafficking protein particle complex 11
TRAPPC13 trafficking protein particle complex 13
TRIM9 tripartite motif containing 9
TRMT1L tRNA methyltransferase 1 homolog (S. cerevisiae)-like
TRMU tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
TSPAN15 tetraspanin 15
TUBG2 tubulin, gamma 2
USP27X ubiquitin specific peptidase 27, X-linked
YIPF1 Yip1 domain family, member 1
ZAK sterile alpha motif and leucine zipper containing kinase AZK
ZC3H12A zinc finger CCCH-type containing 12A
ZNF253 zinc finger protein 253
ZNF254 zinc finger protein 254
ZNF324 zinc finger protein 324
ZNF528 zinc finger protein 528