propofol-5306 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the propofol-5306 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACOX3 acyl-CoA oxidase 3, pristanoyl
ADAP1 ArfGAP with dual PH domains 1
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
ATF3 activating transcription factor 3
BAHCC1 BAH domain and coiled-coil containing 1
BAZ1B bromodomain adjacent to zinc finger domain, 1B
BCL2L1 BCL2-like 1
BTD biotinidase
CCL5 chemokine (C-C motif) ligand 5
CDC14A cell division cycle 14A
CEP162 centrosomal protein 162kDa
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CIC capicua transcriptional repressor
CIDEB cell death-inducing DFFA-like effector b
CNR2 cannabinoid receptor 2 (macrophage)
CUL9 cullin 9
CYHR1 cysteine/histidine-rich 1
DDIT4 DNA-damage-inducible transcript 4
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
DHRS3 dehydrogenase/reductase (SDR family) member 3
DNAJB12 DnaJ (Hsp40) homolog, subfamily B, member 12
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DTNA dystrobrevin, alpha
DTX2P1-UPK3BP1-PMS2P11 DTX2P1-UPK3BP1-PMS2P11 readthrough transcribed pseudogene
E2F4 E2F transcription factor 4, p107/p130-binding
EGR1 early growth response 1
ERN2 endoplasmic reticulum to nucleus signaling 2
HAUS5 HAUS augmin-like complex, subunit 5
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HIST1H1D histone cluster 1, H1d
HLA-B major histocompatibility complex, class I, B
HLA-G major histocompatibility complex, class I, G
HN1L hematological and neurological expressed 1-like
IFI27 interferon, alpha-inducible protein 27
IFI35 interferon-induced protein 35
IFI6 interferon, alpha-inducible protein 6
IFIH1 interferon induced with helicase C domain 1
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
IFIT5 interferon-induced protein with tetratricopeptide repeats 5
IFITM1 interferon induced transmembrane protein 1
INHBE inhibin, beta E
IQCK IQ motif containing K
IRF1 interferon regulatory factor 1
IRF7 interferon regulatory factor 7
IRF9 interferon regulatory factor 9
IRS2 insulin receptor substrate 2
ISG15 ISG15 ubiquitin-like modifier
ISG20 interferon stimulated exonuclease gene 20kDa
JUN jun proto-oncogene
KCNG1 potassium channel, voltage gated modifier subfamily G, member 1
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KLHL24 kelch-like family member 24
KRT17 keratin 17, type I
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGOH2P mago-nashi homolog 2, pseudogene
MAP4 microtubule-associated protein 4
MXD3 MAX dimerization protein 3
MZF1 myeloid zinc finger 1
NDUFA2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
OASL 2'-5'-oligoadenylate synthetase-like
PARP12 poly (ADP-ribose) polymerase family, member 12
PCGF2 polycomb group ring finger 2
PCLO piccolo presynaptic cytomatrix protein
PLA2G4C phospholipase A2, group IVC (cytosolic, calcium-independent)
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLCG1 phospholipase C, gamma 1
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
PLEKHO2 pleckstrin homology domain containing, family O member 2
PLSCR1 phospholipid scramblase 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha
PSG4 pregnancy specific beta-1-glycoprotein 4
QKI QKI, KH domain containing, RNA binding
RASAL1 RAS protein activator like 1 (GAP1 like)
RPGR retinitis pigmentosa GTPase regulator
S100A4 S100 calcium binding protein A4
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SP100 SP100 nuclear antigen
SP110 SP110 nuclear body protein
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STAT1 signal transducer and activator of transcription 1, 91kDa
STBD1 starch binding domain 1
STX5 syntaxin 5
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
SYBU syntabulin (syntaxin-interacting)
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TRIM21 tripartite motif containing 21
UBE2L6 ubiquitin-conjugating enzyme E2L 6
ZC3HAV1 zinc finger CCCH-type, antiviral 1
ZHX3 zinc fingers and homeoboxes 3

decreased expression

Symbol Name
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ACTN4 actinin, alpha 4
ADORA2B adenosine A2b receptor
ADRA2C adrenoceptor alpha 2C
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3
ANKZF1 ankyrin repeat and zinc finger domain containing 1
ARID5B AT rich interactive domain 5B (MRF1-like)
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
ATP13A2 ATPase type 13A2
AUH AU RNA binding protein/enoyl-CoA hydratase
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1
BIK BCL2-interacting killer (apoptosis-inducing)
C10ORF88 chromosome 10 open reading frame 88
CCNJ cyclin J
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CEPT1 choline/ethanolamine phosphotransferase 1
CNPY3 canopy FGF signaling regulator 3
COPS7A COP9 signalosome subunit 7A
CRYZ crystallin, zeta (quinone reductase)
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DUSP5 dual specificity phosphatase 5
DZANK1 double zinc ribbon and ankyrin repeat domains 1
EXOC5 exocyst complex component 5
F8 coagulation factor VIII, procoagulant component
FAM169A family with sequence similarity 169, member A
FAM172A family with sequence similarity 172, member A
FAM189B family with sequence similarity 189, member B
FPGT fucose-1-phosphate guanylyltransferase
GAR1 GAR1 ribonucleoprotein
GCA grancalcin, EF-hand calcium binding protein
GLI3 GLI family zinc finger 3
GMCL1 germ cell-less, spermatogenesis associated 1
GMEB1 glucocorticoid modulatory element binding protein 1
GNL3LP1 guanine nucleotide binding protein-like 3 (nucleolar)-like pseudogene 1
GPR19 G protein-coupled receptor 19
HECA headcase homolog (Drosophila)
HMGB3P1 high mobility group box 3 pseudogene 1
HOXC6 homeobox C6
HP1BP3 heterochromatin protein 1, binding protein 3
ICK intestinal cell (MAK-like) kinase
IRF6 interferon regulatory factor 6
KIAA1551 KIAA1551
LAMB2 laminin, beta 2 (laminin S)
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1
MAPKBP1 mitogen-activated protein kinase binding protein 1
MBTD1 mbt domain containing 1
MEIS2 Meis homeobox 2
MKNK2 MAP kinase interacting serine/threonine kinase 2
MPI mannose phosphate isomerase
MSX1 msh homeobox 1
MTCL1 microtubule crosslinking factor 1
MUTYH mutY homolog
NPY1R neuropeptide Y receptor Y1
OLFML3 olfactomedin-like 3
OPN3 opsin 3
OSGEPL1 O-sialoglycoprotein endopeptidase-like 1
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)
PGP phosphoglycolate phosphatase
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
PLGRKT plasminogen receptor, C-terminal lysine transmembrane protein
POMT1 protein-O-mannosyltransferase 1
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PTOV1 prostate tumor overexpressed 1
RAB33B RAB33B, member RAS oncogene family
RGS19 regulator of G-protein signaling 19
RIBC2 RIB43A domain with coiled-coils 2
RNF123 ring finger protein 123
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
RPL39L ribosomal protein L39-like
SCAI suppressor of cancer cell invasion
SCML1 sex comb on midleg-like 1 (Drosophila)
SCUBE2 signal peptide, CUB domain, EGF-like 2
SGPP1 sphingosine-1-phosphate phosphatase 1
SLC2A8 solute carrier family 2 (facilitated glucose transporter), member 8
SLC35F5 solute carrier family 35, member F5
SNHG3 small nucleolar RNA host gene 3
SOAT1 sterol O-acyltransferase 1
SOX12 SRY (sex determining region Y)-box 12
SYT17 synaptotagmin XVII
TARBP1 TAR (HIV-1) RNA binding protein 1
TESK1 testis-specific kinase 1
TMEM14B transmembrane protein 14B
TMEM38B transmembrane protein 38B
TNRC6B trinucleotide repeat containing 6B
TPST2 tyrosylprotein sulfotransferase 2
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TRIM52 tripartite motif containing 52
TRMT61A tRNA methyltransferase 61A
TUBA3C tubulin, alpha 3c
TWSG1 twisted gastrulation BMP signaling modulator 1
UBXN8 UBX domain protein 8
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae)
WWC2 WW and C2 domain containing 2
ZNF205 zinc finger protein 205
ZNF35 zinc finger protein 35
ZNF408 zinc finger protein 408
ZNF580 zinc finger protein 580
ZNF675 zinc finger protein 675