propofol-6707 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the propofol-6707 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
A1CF APOBEC1 complementation factor
ADAM23 ADAM metallopeptidase domain 23
ADGRE2 adhesion G protein-coupled receptor E2
APC adenomatous polyposis coli
ARHGAP22 Rho GTPase activating protein 22
ATN1 atrophin 1
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1
BBC3 BCL2 binding component 3
BMP3 bone morphogenetic protein 3
BMP7 bone morphogenetic protein 7
BRSK2 BR serine/threonine kinase 2
CASS4 Cas scaffolding protein family member 4
CCDC170 coiled-coil domain containing 170
CD58 CD58 molecule
CFAP43 cilia and flagella associated protein 43
CHI3L2 chitinase 3-like 2
CHRNA9 cholinergic receptor, nicotinic, alpha 9 (neuronal)
CHRNE cholinergic receptor, nicotinic, epsilon (muscle)
CNGB3 cyclic nucleotide gated channel beta 3
COBL cordon-bleu WH2 repeat protein
COL9A2 collagen, type IX, alpha 2
CRMP1 collapsin response mediator protein 1
CSPG4 chondroitin sulfate proteoglycan 4
DCT dopachrome tautomerase
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DZIP1 DAZ interacting zinc finger protein 1
EDA ectodysplasin A
EPS8L1 EPS8-like 1
ERAP1 endoplasmic reticulum aminopeptidase 1
FAM46C family with sequence similarity 46, member C
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
FLT3LG fms-related tyrosine kinase 3 ligand
FOS FBJ murine osteosarcoma viral oncogene homolog
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GPR19 G protein-coupled receptor 19
GPR75 G protein-coupled receptor 75
GSTTP1 glutathione S-transferase theta pseudogene 1
HAUS5 HAUS augmin-like complex, subunit 5
HEMK1 HemK methyltransferase family member 1
HOXC4 homeobox C4
HOXD11 homeobox D11
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
IGF1 insulin-like growth factor 1 (somatomedin C)
IGFBP7 insulin-like growth factor binding protein 7
IGSF6 immunoglobulin superfamily, member 6
IL12B interleukin 12B
IL16 interleukin 16
IL6R interleukin 6 receptor
KCNE2 potassium channel, voltage gated subfamily E regulatory beta subunit 2
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5
KCNQ3 potassium channel, voltage gated KQT-like subfamily Q, member 3
KCNV1 potassium channel, voltage gated modifier subfamily V, member 1
KIAA1467 KIAA1467
LLPH LLP homolog, long-term synaptic facilitation (Aplysia)
LTBP4 latent transforming growth factor beta binding protein 4
MFAP3L microfibrillar-associated protein 3-like
MMP24 matrix metallopeptidase 24 (membrane-inserted)
MSX2 msh homeobox 2
MVD mevalonate (diphospho) decarboxylase
MYH14 myosin, heavy chain 14, non-muscle
MYOZ3 myozenin 3
NF1 neurofibromin 1
OASL 2'-5'-oligoadenylate synthetase-like
OSGIN1 oxidative stress induced growth inhibitor 1
PADI1 peptidyl arginine deiminase, type I
PIN1P1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 pseudogene 1
PLXNB3 plexin B3
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PRKG1 protein kinase, cGMP-dependent, type I
PROX1 prospero homeobox 1
PTCRA pre T-cell antigen receptor alpha
PTPRB protein tyrosine phosphatase, receptor type, B
PTRF polymerase I and transcript release factor
RAB36 RAB36, member RAS oncogene family
RBM12B-AS1 RBM12B antisense RNA 1
RND2 Rho family GTPase 2
RUNX1 runt-related transcription factor 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SPTB spectrin, beta, erythrocytic
SSX7 synovial sarcoma, X breakpoint 7
TADA3 transcriptional adaptor 3
THSD7A thrombospondin, type I, domain containing 7A
TLR1 toll-like receptor 1
TLR4 toll-like receptor 4
TNS1 tensin 1
TRIM10 tripartite motif containing 10
TTC38 tetratricopeptide repeat domain 38
TXNRD2 thioredoxin reductase 2
UPK1B uroplakin 1B
WDR78 WD repeat domain 78
ZBTB17 zinc finger and BTB domain containing 17
ZBTB20 zinc finger and BTB domain containing 20
ZNF214 zinc finger protein 214
ZNF500 zinc finger protein 500
ZNF783 zinc finger family member 783
ZZEF1 zinc finger, ZZ-type with EF-hand domain 1

decreased expression

Symbol Name
AGPAT4 1-acylglycerol-3-phosphate O-acyltransferase 4
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle)
APLP1 amyloid beta (A4) precursor-like protein 1
ARHGAP5 Rho GTPase activating protein 5
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
ATAT1 alpha tubulin acetyltransferase 1
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
BEX1 brain expressed, X-linked 1
C14ORF93 chromosome 14 open reading frame 93
C17ORF70 chromosome 17 open reading frame 70
CAMTA2 calmodulin binding transcription activator 2
CCP110 centriolar coiled coil protein 110kDa
CEL carboxyl ester lipase
CEP131 centrosomal protein 131kDa
CHRDL1 chordin-like 1
CLCN6 chloride channel, voltage-sensitive 6
CLUHP3 clustered mitochondria (cluA/CLU1) homolog pseudogene 3
CNTLN centlein, centrosomal protein
CORO1A coronin, actin binding protein, 1A
CYP2R1 cytochrome P450, family 2, subfamily R, polypeptide 1
DENND3 DENN/MADD domain containing 3
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1
EFNB1 ephrin-B1
ERMP1 endoplasmic reticulum metallopeptidase 1
ERN2 endoplasmic reticulum to nucleus signaling 2
F3 coagulation factor III (thromboplastin, tissue factor)
FAM204A family with sequence similarity 204, member A
FANCC Fanconi anemia, complementation group C
FARP2 FERM, RhoGEF and pleckstrin domain protein 2
FAT4 FAT atypical cadherin 4
FLCN folliculin
FZD6 frizzled class receptor 6
GSTA3 glutathione S-transferase alpha 3
GUSBP3 glucuronidase, beta pseudogene 3
HAMP hepcidin antimicrobial peptide
HDAC7 histone deacetylase 7
HIST1H1T histone cluster 1, H1t
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HNRNPA3P1 heterogeneous nuclear ribonucleoprotein A3 pseudogene 1
HOOK1 hook microtubule-tethering protein 1
HP1BP3 heterochromatin protein 1, binding protein 3
IFI6 interferon, alpha-inducible protein 6
IL36RN interleukin 36 receptor antagonist
IRAK4 interleukin-1 receptor-associated kinase 4
KIAA0922 KIAA0922
KLHL28 kelch-like family member 28
LOC100287590 uncharacterized LOC100287590
LRRC61 leucine rich repeat containing 61
MANBA mannosidase, beta A, lysosomal
MOXD1 monooxygenase, DBH-like 1
MRPL44 mitochondrial ribosomal protein L44
MRPS18C mitochondrial ribosomal protein S18C
MUC3A mucin 3A, cell surface associated
NAG18 NAG18 mRNA
NAT6 N-acetyltransferase 6 (GCN5-related)
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
ODF2 outer dense fiber of sperm tails 2
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)
OSMR oncostatin M receptor
PCDHGB5 protocadherin gamma subfamily B, 5
PDE8B phosphodiesterase 8B
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PLAG1 pleiomorphic adenoma gene 1
PLD2 phospholipase D2
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit
PRF1 perforin 1 (pore forming protein)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
R3HCC1L R3H domain and coiled-coil containing 1-like
SCAMP5 secretory carrier membrane protein 5
SETD8 SET domain containing (lysine methyltransferase) 8
SH3TC2 SH3 domain and tetratricopeptide repeats 2
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STX5 syntaxin 5
TAOK1 TAO kinase 1
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TBX19 T-box 19
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TINAGL1 tubulointerstitial nephritis antigen-like 1
TMEM159 transmembrane protein 159
TMEM19 transmembrane protein 19
TNFSF12 tumor necrosis factor (ligand) superfamily, member 12
TRPM4 transient receptor potential cation channel, subfamily M, member 4
TRPV6 transient receptor potential cation channel, subfamily V, member 6
TXLNG taxilin gamma
USP19 ubiquitin specific peptidase 19
VEZT vezatin, adherens junctions transmembrane protein
WDR25 WD repeat domain 25
WDR33 WD repeat domain 33
YOD1 YOD1 deubiquitinase
ZBTB6 zinc finger and BTB domain containing 6
ZFAND3 zinc finger, AN1-type domain 3
ZNF141 zinc finger protein 141
ZNF408 zinc finger protein 408
ZNF629 zinc finger protein 629