propoxycaine-3583 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the propoxycaine-3583 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AAK1 AP2 associated kinase 1
ALOXE3 arachidonate lipoxygenase 3
APOM apolipoprotein M
AQP1 aquaporin 1 (Colton blood group)
BAZ2A bromodomain adjacent to zinc finger domain, 2A
BCL3 B-cell CLL/lymphoma 3
BEST1 bestrophin 1
BRS3 bombesin-like receptor 3
BZRAP1 benzodiazepine receptor (peripheral) associated protein 1
CACNA1I calcium channel, voltage-dependent, T type, alpha 1I subunit
CACNG1 calcium channel, voltage-dependent, gamma subunit 1
CCDC57 coiled-coil domain containing 57
CCKAR cholecystokinin A receptor
CCPG1 cell cycle progression 1
CCRL2 chemokine (C-C motif) receptor-like 2
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CDKL5 cyclin-dependent kinase-like 5
CLCN7 chloride channel, voltage-sensitive 7
CLDN17 claudin 17
CLSTN2 calsyntenin 2
CRHR2 corticotropin releasing hormone receptor 2
DMP1 dentin matrix acidic phosphoprotein 1
EBF2 early B-cell factor 2
EFNA3 ephrin-A3
EIF3F eukaryotic translation initiation factor 3, subunit F
ELAVL3 ELAV like neuron-specific RNA binding protein 3
EPHB2 EPH receptor B2
EPHX2 epoxide hydrolase 2, cytoplasmic
FAM149A family with sequence similarity 149, member A
FBXO41 F-box protein 41
FFAR3 free fatty acid receptor 3
FGF4 fibroblast growth factor 4
FGFR3 fibroblast growth factor receptor 3
FLI1 Fli-1 proto-oncogene, ETS transcription factor
GPM6A glycoprotein M6A
HEG1 heart development protein with EGF-like domains 1
HOMER3 homer scaffolding protein 3
HPX hemopexin
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
IL11 interleukin 11
IL23A interleukin 23, alpha subunit p19
IRF2BP1 interferon regulatory factor 2 binding protein 1
KCNAB2 potassium channel, voltage gated subfamily A regulatory beta subunit 2
KIR2DL1 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1
KLK8 kallikrein-related peptidase 8
MAPK11 mitogen-activated protein kinase 11
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MMP19 matrix metallopeptidase 19
NBL1 neuroblastoma 1, DAN family BMP antagonist
NF1 neurofibromin 1
NOX1 NADPH oxidase 1
NPHP4 nephronophthisis 4
NPTXR neuronal pentraxin receptor
NR1I3 nuclear receptor subfamily 1, group I, member 3
OBSL1 obscurin-like 1
ONECUT2 one cut homeobox 2
OR7E87P olfactory receptor, family 7, subfamily E, member 87 pseudogene
PDE4DIP phosphodiesterase 4D interacting protein
PKD2L1 polycystic kidney disease 2-like 1
PKNOX2 PBX/knotted 1 homeobox 2
PLXNA2 plexin A2
PNPLA3 patatin-like phospholipase domain containing 3
PSG6 pregnancy specific beta-1-glycoprotein 6
PTCH1 patched 1
PTGER3 prostaglandin E receptor 3 (subtype EP3)
PTK7 protein tyrosine kinase 7 (inactive)
PTN pleiotrophin
PTPRM protein tyrosine phosphatase, receptor type, M
RARA retinoic acid receptor, alpha
RPH3A rabphilin 3A
RUNX1 runt-related transcription factor 1
SCN2B sodium channel, voltage gated, type II beta subunit
SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)
SETD1A SET domain containing 1A
SMAD1 SMAD family member 1
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SNCAIP synuclein, alpha interacting protein
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
SSTR4 somatostatin receptor 4
SYN3 synapsin III
TAOK2 TAO kinase 2
TAPBP TAP binding protein (tapasin)
TMEM246 transmembrane protein 246
TMEM63A transmembrane protein 63A
TRA T cell receptor alpha locus
TREM1 triggering receptor expressed on myeloid cells 1
TREM2 triggering receptor expressed on myeloid cells 2
TSHR thyroid stimulating hormone receptor
TTC38 tetratricopeptide repeat domain 38
UTRN utrophin
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2)
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
WWP2 WW domain containing E3 ubiquitin protein ligase 2
YIF1B Yip1 interacting factor homolog B (S. cerevisiae)
ZNF112 zinc finger protein 112
ZNF230 zinc finger protein 230
ZNF358 zinc finger protein 358
ZNF821 zinc finger protein 821
ZSCAN2 zinc finger and SCAN domain containing 2

decreased expression

Symbol Name
ACTL8 actin-like 8
ADAP2 ArfGAP with dual PH domains 2
ADGRE5 adhesion G protein-coupled receptor E5
ALDOC aldolase C, fructose-bisphosphate
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17
ARRB1 arrestin, beta 1
BCAS1 breast carcinoma amplified sequence 1
BCL9 B-cell CLL/lymphoma 9
BPHL biphenyl hydrolase-like (serine hydrolase)
BTF3P12 basic transcription factor 3 pseudogene 12
CCDC132 coiled-coil domain containing 132
CCNL2 cyclin L2
CD82 CD82 molecule
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant
CTAGE9 CTAGE family, member 9
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
CUL9 cullin 9
CUZD1 CUB and zona pellucida-like domains 1
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DECR2 2,4-dienoyl CoA reductase 2, peroxisomal
DNM1 dynamin 1
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DUSP2 dual specificity phosphatase 2
EFCAB2 EF-hand calcium binding domain 2
EIF5A2 eukaryotic translation initiation factor 5A2
EMID1 EMI domain containing 1
ENO2 enolase 2 (gamma, neuronal)
FAM189A2 family with sequence similarity 189, member A2
FBXL15 F-box and leucine-rich repeat protein 15
FBXL7 F-box and leucine-rich repeat protein 7
FKBP5 FK506 binding protein 5
FOXN2 forkhead box N2
GFPT2 glutamine-fructose-6-phosphate transaminase 2
GMEB1 glucocorticoid modulatory element binding protein 1
GPATCH3 G patch domain containing 3
HIST1H1D histone cluster 1, H1d
HOXC10 homeobox C10
IFITM1 interferon induced transmembrane protein 1
IFT140 intraflagellar transport 140
IRF2 interferon regulatory factor 2
LARP6 La ribonucleoprotein domain family, member 6
LIN7A lin-7 homolog A (C. elegans)
LOC202181 SUMO-interacting motifs containing 1 pseudogene
LPXN leupaxin
LRRC61 leucine rich repeat containing 61
LZTS3 leucine zipper, putative tumor suppressor family member 3
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
MED9 mediator complex subunit 9
MEFV Mediterranean fever
MFSD11 major facilitator superfamily domain containing 11
MMP15 matrix metallopeptidase 15 (membrane-inserted)
MPP2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)
MTERF4 mitochondrial transcription termination factor 4
NBEAL2 neurobeachin-like 2
NDUFAF7 NADH dehydrogenase (ubiquinone) complex I, assembly factor 7
NT5C 5', 3'-nucleotidase, cytosolic
PARD6A par-6 family cell polarity regulator alpha
PHC1 polyhomeotic homolog 1 (Drosophila)
PIGZ phosphatidylinositol glycan anchor biosynthesis, class Z
PKN1 protein kinase N1
PNPLA6 patatin-like phospholipase domain containing 6
PRKRIP1 PRKR interacting protein 1 (IL11 inducible)
PTPRU protein tyrosine phosphatase, receptor type, U
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
RNF31 ring finger protein 31
SCGB2A2 secretoglobin, family 2A, member 2
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SIX1 SIX homeobox 1
SKIV2L superkiller viralicidic activity 2-like (S. cerevisiae)
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SLMO1 slowmo homolog 1 (Drosophila)
SMEK2 SMEK homolog 2, suppressor of mek1 (Dictyostelium)
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SPINK4 serine peptidase inhibitor, Kazal type 4
ST5 suppression of tumorigenicity 5
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
TARP TCR gamma alternate reading frame protein
TDRKH tudor and KH domain containing
TEAD3 TEA domain family member 3
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TLN1 talin 1
TMEM120B transmembrane protein 120B
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
TPK1 thiamin pyrophosphokinase 1
TSSC4 tumor suppressing subtransferable candidate 4
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific
USP27X ubiquitin specific peptidase 27, X-linked
VAV1 vav 1 guanine nucleotide exchange factor
VAX2 ventral anterior homeobox 2
WDR76 WD repeat domain 76
ZDHHC24 zinc finger, DHHC-type containing 24
ZNF767P zinc finger family member 767, pseudogene
ZNRD1-AS1 ZNRD1 antisense RNA 1