proscillaridin-4404 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the proscillaridin-4404 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADM adrenomedullin
AFF4 AF4/FMR2 family, member 4
AMOTL2 angiomotin like 2
ATF3 activating transcription factor 3
ATF7IP activating transcription factor 7 interacting protein
AVPI1 arginine vasopressin-induced 1
BCL6 B-cell CLL/lymphoma 6
CCNL1 cyclin L1
CDK19 cyclin-dependent kinase 19
CDKN2AIP CDKN2A interacting protein
CLDN1 claudin 1
CLK1 CDC-like kinase 1
CLK4 CDC-like kinase 4
CNOT4 CCR4-NOT transcription complex, subunit 4
CTGF connective tissue growth factor
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT3 DNA-damage-inducible transcript 3
DLX2 distal-less homeobox 2
DMWD dystrophia myotonica, WD repeat containing
DUSP1 dual specificity phosphatase 1
DUSP4 dual specificity phosphatase 4
EDN1 endothelin 1
EED embryonic ectoderm development
EFNA1 ephrin-A1
EGR1 early growth response 1
EGR2 early growth response 2
EIF1 eukaryotic translation initiation factor 1
EPHA2 EPH receptor A2
FLCN folliculin
FOS FBJ murine osteosarcoma viral oncogene homolog
GEM GTP binding protein overexpressed in skeletal muscle
HBP1 HMG-box transcription factor 1
HCFC2 host cell factor C2
HIC2 hypermethylated in cancer 2
HIST1H1T histone cluster 1, H1t
HIST1H4C histone cluster 1, H4c
HIST1H4E histone cluster 1, H4e
HOXC13 homeobox C13
IER2 immediate early response 2
IL11 interleukin 11
IL6 interleukin 6
IP6K2 inositol hexakisphosphate kinase 2
IRS2 insulin receptor substrate 2
JUN jun proto-oncogene
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1
KLF10 Kruppel-like factor 10
KLF6 Kruppel-like factor 6
KLHL20 kelch-like family member 20
KLHL24 kelch-like family member 24
LINS lines homolog (Drosophila)
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G
MCL1 myeloid cell leukemia 1
MCM3AP minichromosome maintenance complex component 3 associated protein
MED6 mediator complex subunit 6
MXD1 MAX dimerization protein 1
N4BP2L2 NEDD4 binding protein 2-like 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
OVOL1 ovo-like zinc finger 1
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
PNRC1 proline-rich nuclear receptor coactivator 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RBM5 RNA binding motif protein 5
RGS16 regulator of G-protein signaling 16
RLF rearranged L-myc fusion
RSRC2 arginine/serine-rich coiled-coil 2
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
SCUBE3 signal peptide, CUB domain, EGF-like 3
SERTAD3 SERTA domain containing 3
SKIL SKI-like proto-oncogene
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SMEK1 SMEK homolog 1, suppressor of mek1 (Dictyostelium)
SPRY4 sprouty homolog 4 (Drosophila)
SRSF5 serine/arginine-rich splicing factor 5
STX3 syntaxin 3
TCF25 transcription factor 25 (basic helix-loop-helix)
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TPP1 tripeptidyl peptidase I
TXNIP thioredoxin interacting protein
UBE2H ubiquitin-conjugating enzyme E2H
VCL vinculin
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing
YTHDC1 YTH domain containing 1
ZBTB40 zinc finger and BTB domain containing 40
ZBTB43 zinc finger and BTB domain containing 43
ZEB1 zinc finger E-box binding homeobox 1
ZMYM2 zinc finger, MYM-type 2
ZMYM5 zinc finger, MYM-type 5
ZNF335 zinc finger protein 335
ZNF654 zinc finger protein 654

decreased expression

Symbol Name
ABHD10 abhydrolase domain containing 10
ADAT1 adenosine deaminase, tRNA-specific 1
AMIGO2 adhesion molecule with Ig-like domain 2
ANKRD46 ankyrin repeat domain 46
ARMCX1 armadillo repeat containing, X-linked 1
ASB13 ankyrin repeat and SOCS box containing 13
ASTN2 astrotactin 2
BMP4 bone morphogenetic protein 4
C17ORF80 chromosome 17 open reading frame 80
C2ORF68 chromosome 2 open reading frame 68
CABYR calcium binding tyrosine-(Y)-phosphorylation regulated
CBR3 carbonyl reductase 3
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DEAF1 DEAF1 transcription factor
DET1 de-etiolated homolog 1 (Arabidopsis)
DNAAF2 dynein, axonemal, assembly factor 2
DNAJC17 DnaJ (Hsp40) homolog, subfamily C, member 17
ECHDC3 enoyl CoA hydratase domain containing 3
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase
EIF2B3 eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa
ERMAP erythroblast membrane-associated protein (Scianna blood group)
ETAA1 Ewing tumor-associated antigen 1
FADD Fas (TNFRSF6)-associated via death domain
FAM86B1 family with sequence similarity 86, member B1
FAM86C1 family with sequence similarity 86, member C1
FANCF Fanconi anemia, complementation group F
GEMIN4 gem (nuclear organelle) associated protein 4
GEMIN6 gem (nuclear organelle) associated protein 6
GPR19 G protein-coupled receptor 19
HIRIP3 HIRA interacting protein 3
HPS6 Hermansky-Pudlak syndrome 6
HSPA1L heat shock 70kDa protein 1-like
ICT1 immature colon carcinoma transcript 1
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IRF6 interferon regulatory factor 6
ITPKB inositol-trisphosphate 3-kinase B
JRKL JRK-like
KIZ kizuna centrosomal protein
KRCC1 lysine-rich coiled-coil 1
LOC100287590 uncharacterized LOC100287590
LOC730101 uncharacterized LOC730101
MKKS McKusick-Kaufman syndrome
MKS1 Meckel syndrome, type 1
ORC3 origin recognition complex, subunit 3
OXSM 3-oxoacyl-ACP synthase, mitochondrial
PAAF1 proteasomal ATPase-associated factor 1
PAGR1 PAXIP1 associated glutamate-rich protein 1
PALB2 partner and localizer of BRCA2
PCF11 PCF11 cleavage and polyadenylation factor subunit
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PPM1F protein phosphatase, Mg2+/Mn2+ dependent, 1F
PPP1R3D protein phosphatase 1, regulatory subunit 3D
PRMT7 protein arginine methyltransferase 7
PRR15L proline rich 15-like
PRR3 proline rich 3
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1
RDH14 retinol dehydrogenase 14 (all-trans/9-cis/11-cis)
RHOBTB1 Rho-related BTB domain containing 1
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
RPP40 ribonuclease P/MRP 40kDa subunit
RPUSD2 RNA pseudouridylate synthase domain containing 2
RSAD1 radical S-adenosyl methionine domain containing 1
RUFY2 RUN and FYVE domain containing 2
S100PBP S100P binding protein
SACS sacsin molecular chaperone
SCAI suppressor of cancer cell invasion
SCO2 SCO2 cytochrome c oxidase assembly protein
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5
SLC25A28 solute carrier family 25 (mitochondrial iron transporter), member 28
SLC33A1 solute carrier family 33 (acetyl-CoA transporter), member 1
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SPC25 SPC25, NDC80 kinetochore complex component
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
TFB1M transcription factor B1, mitochondrial
THAP7 THAP domain containing 7
THNSL1 threonine synthase-like 1 (S. cerevisiae)
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TRAPPC11 trafficking protein particle complex 11
TRIM16 tripartite motif containing 16
TRIM45 tripartite motif containing 45
TRMT1L tRNA methyltransferase 1 homolog (S. cerevisiae)-like
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TXNRD3 thioredoxin reductase 3
WDR25 WD repeat domain 25
WDR3 WD repeat domain 3
XBP1 X-box binding protein 1
ZBED8 zinc finger, BED-type containing 8
ZBTB24 zinc finger and BTB domain containing 24
ZFP69B ZFP69 zinc finger protein B
ZKSCAN3 zinc finger with KRAB and SCAN domains 3
ZNF23 zinc finger protein 23
ZNF239 zinc finger protein 239
ZNF248 zinc finger protein 248
ZNF623 zinc finger protein 623
ZNF696 zinc finger protein 696
ZSCAN31 zinc finger and SCAN domain containing 31
ZSCAN9 zinc finger and SCAN domain containing 9