protease binding Gene Set

Dataset GO Molecular Function Annotations 2025
Category structural or functional annotations
Type molecular function
Description Interacting selectively and non-covalently with any protease or peptidase. (Gene Ontology, GO_0002020)
External Link http://amigo.geneontology.org/amigo/term/GO:0002020
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Genes

120 genes performing the protease binding molecular function from the curated GO Molecular Function Annotations 2025 dataset.

Symbol Name
A2M alpha-2-macroglobulin
ACR acrosin
ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif, 4
ADAMTSL4 ADAMTS-like 4
ADRM1 adhesion regulating molecule 1
ALPP alkaline phosphatase, placental
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
ANXA2 annexin A2
ATP9A ATPase, class II, type 9A
BAG6 BCL2-associated athanogene 6
BANK1 B-cell scaffold protein with ankyrin repeats 1
BCL10 B-cell CLL/lymphoma 10
BCL2 B-cell CLL/lymphoma 2
BCL2L10 BCL2-like 10 (apoptosis facilitator)
BDKRB2 bradykinin receptor B2
BFAR bifunctional apoptosis regulator
BIN1 bridging integrator 1
BRCA2 breast cancer 2, early onset
CARD16 caspase recruitment domain family, member 16
CARD18 caspase recruitment domain family, member 18
CCBE1 collagen and calcium binding EGF domains 1
CD177 CD177 molecule
CFLAR CASP8 and FADD-like apoptosis regulator
CLTC clathrin, heavy chain (Hc)
COL1A1 collagen, type I, alpha 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COMP cartilage oligomeric matrix protein
CRADD CASP2 and RIPK1 domain containing adaptor with death domain
CST3 cystatin C
CST7 cystatin F (leukocystatin)
CSTA cystatin A (stefin A)
CSTB cystatin B (stefin B)
CTSG cathepsin G
DERL1 derlin 1
DPP4 dipeptidyl-peptidase 4
DVL3 dishevelled segment polarity protein 3
ECM1 extracellular matrix protein 1
ELANE elastase, neutrophil expressed
F2RL1 coagulation factor II (thrombin) receptor-like 1
F2RL3 coagulation factor II (thrombin) receptor-like 3
F3 coagulation factor III (thromboplastin, tissue factor)
FADD Fas (TNFRSF6)-associated via death domain
FAM20C family with sequence similarity 20, member C
FCER2 Fc fragment of IgE, low affinity II, receptor for (CD23)
FLOT1 flotillin 1
FLOT2 flotillin 2
FN1 fibronectin 1
FURIN furin (paired basic amino acid cleaving enzyme)
GLMN glomulin, FKBP associated protein
GSK3B glycogen synthase kinase 3 beta
INS insulin
INSL3 insulin-like 3 (Leydig cell)
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
ITGAV integrin, alpha V
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
LCOR ligand dependent nuclear receptor corepressor
LDLR low density lipoprotein receptor
LONP2 lon peptidase 2, peroxisomal
MAGEA3 melanoma antigen family A3
MARCHF6 membrane associated ring-CH-type finger 6
NFRKB nuclear factor related to kappaB binding protein
NHERF4 NHERF family PDZ scaffold protein 4
NLRC4 NLR family, CARD domain containing 4
NLRP7 NLR family, pyrin domain containing 7
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PARK7 parkinson protein 7
PINK1 PTEN induced putative kinase 1
PLG plasminogen
POLGARF POLG alternative reading frame
PRKN parkin RBR E3 ubiquitin protein ligase
PRNP prion protein
PTEN phosphatase and tensin homolog
PYCARD PYD and CARD domain containing
PZP pregnancy-zone protein
RAD23A RAD23 homolog A (S. cerevisiae)
RFFL ring finger and FYVE-like domain containing E3 ubiquitin protein ligase
RIOK3 RIO kinase 3
RIPK2 receptor-interacting serine-threonine kinase 2
RNF103-CHMP3 RNF103-CHMP3 readthrough
RNF139 ring finger protein 139
ROCK2 Rho-associated, coiled-coil containing protein kinase 2
SART3 squamous cell carcinoma antigen recognized by T cells 3
SELENOS selenoprotein S
SELL selectin L
SEMG2 semenogelin II
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPINB13 serpin peptidase inhibitor, clade B (ovalbumin), member 13
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINF2 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
SFTPA2 surfactant protein A2
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13
SPATA2 spermatogenesis associated 2
SRI sorcin
STIM1 stromal interaction molecule 1
SUMO1 small ubiquitin-like modifier 1
SYVN1 synovial apoptosis inhibitor 1, synoviolin
THAP5 THAP domain containing 5
THBS1 thrombospondin 1
TIMP2 TIMP metallopeptidase inhibitor 2
TNF tumor necrosis factor
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a
TNFRSF8 tumor necrosis factor receptor superfamily, member 8
TP53 tumor protein p53
TRIP4 thyroid hormone receptor interactor 4
TTR transthyretin
TWNK twinkle mtDNA helicase
TYSND1 trypsin domain containing 1
VCP valosin containing protein
VWF von Willebrand factor
XBP1 X-box binding protein 1