proteasomal protein catabolic process Gene Set

Dataset GO Biological Process Annotations 2025
Category structural or functional annotations
Type biological process
Description The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome. (Gene Ontology, GO_0010498)
External Link http://amigo.geneontology.org/amigo/term/GO:0010498
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Genes

373 genes participating in the proteasomal protein catabolic process biological process from the curated GO Biological Process Annotations 2025 dataset.

Symbol Name
ADRM1 adhesion regulating molecule 1
AGAP3 ArfGAP with GTPase domain, ankyrin repeat and PH domain 3
AMBRA1 autophagy/beclin-1 regulator 1
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
ANKRD9 ankyrin repeat domain 9
ANKZF1 ankyrin repeat and zinc finger domain containing 1
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ARIH2 ariadne RBR E3 ubiquitin protein ligase 2
ARMC8 armadillo repeat containing 8
ARRB1 arrestin, beta 1
ARRB2 arrestin, beta 2
ASB1 ankyrin repeat and SOCS box containing 1
ASB11 ankyrin repeat and SOCS box containing 11, E3 ubiquitin protein ligase
ASB2 ankyrin repeat and SOCS box containing 2
ASB9 ankyrin repeat and SOCS box containing 9
ATE1 arginyltransferase 1
ATF6 activating transcription factor 6
ATXN3 ataxin 3
ATXN3L ataxin 3-like
AUP1 ancient ubiquitous protein 1
AXIN1 axin 1
AXIN2 axin 2
BAG6 BCL2-associated athanogene 6
BFAR bifunctional apoptosis regulator
BIRC2 baculoviral IAP repeat containing 2
BMAL1 basic helix-loop-helix ARNT like 1
BRSK2 BR serine/threonine kinase 2
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
CALR calreticulin
CALR3 calreticulin 3
CANX calnexin
CARD16 caspase recruitment domain family, member 16
CCDC47 coiled-coil domain containing 47
CCIN calicin
CDC34 cell division cycle 34
CLOCK clock circadian regulator
CRBN cereblon
CSNK1A1 casein kinase 1, alpha 1
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CUL1 cullin 1
CUL3 cullin 3
CUL4A cullin 4A
CUL4B cullin 4B
CUL5 cullin 5
DCAF1 DDB1 and CUL4 associated factor 1
DCAF11 DDB1 and CUL4 associated factor 11
DCAF13 DDB1 and CUL4 associated factor 13
DDB1 damage-specific DNA binding protein 1, 127kDa
DDI1 DNA-damage inducible 1 homolog 1 (S. cerevisiae)
DDI2 DNA-damage inducible 1 homolog 2 (S. cerevisiae)
DDIT3 DNA-damage-inducible transcript 3
DERL1 derlin 1
DERL2 derlin 2
DERL3 derlin 3
DNAJB12 DnaJ (Hsp40) homolog, subfamily B, member 12
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNAJC10 DnaJ (Hsp40) homolog, subfamily C, member 10
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DTX4 deltex 4, E3 ubiquitin ligase
ECPAS Ecm29 proteasome adaptor and scaffold
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
EDEM2 ER degradation enhancer, mannosidase alpha-like 2
EDEM3 ER degradation enhancer, mannosidase alpha-like 3
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ERCC8 excision repair cross-complementation group 8
ERLEC1 endoplasmic reticulum lectin 1
ERLIN1 ER lipid raft associated 1
ERLIN2 ER lipid raft associated 2
FAF1 Fas (TNFRSF6) associated factor 1
FAF2 Fas associated factor family member 2
FAM8A1 family with sequence similarity 8, member A1
FBXL17 F-box and leucine-rich repeat protein 17
FBXL19 F-box and leucine-rich repeat protein 19
FBXL22 F-box and leucine-rich repeat protein 22
FBXO11 F-box protein 11
FBXO17 F-box protein 17
FBXO2 F-box protein 2
FBXO27 F-box protein 27
FBXO44 F-box protein 44
FBXO45 F-box protein 45
FBXO6 F-box protein 6
FBXO7 F-box protein 7
FBXO9 F-box protein 9
FBXW11 F-box and WD repeat domain containing 11
FBXW5 F-box and WD repeat domain containing 5
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FEM1B fem-1 homolog b (C. elegans)
FEM1C fem-1 homolog c (C. elegans)
FOXRED2 FAD-dependent oxidoreductase domain containing 2
GAN gigaxonin
GET4 golgi to ER traffic protein 4 homolog (S. cerevisiae)
GID4 GID complex subunit 4
GID8 GID complex subunit 8
GSK3A glycogen synthase kinase 3 alpha
GSK3B glycogen synthase kinase 3 beta
HECTD3 HECT domain containing E3 ubiquitin protein ligase 3
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
IFI27 interferon, alpha-inducible protein 27
IPP intracisternal A particle-promoted polypeptide
ITCH itchy E3 ubiquitin protein ligase
IVNS1ABP influenza virus NS1A binding protein
JKAMP JNK1/MAPK8-associated membrane protein
KAT5 K(lysine) acetyltransferase 5
KBTBD12 kelch repeat and BTB (POZ) domain containing 12
KBTBD2 kelch repeat and BTB (POZ) domain containing 2
KBTBD3 kelch repeat and BTB (POZ) domain containing 3
KBTBD6 kelch repeat and BTB (POZ) domain containing 6
KBTBD7 kelch repeat and BTB (POZ) domain containing 7
KBTBD8 kelch repeat and BTB (POZ) domain containing 8
KCMF1 potassium channel modulatory factor 1
KCTD10 potassium channel tetramerization domain containing 10
KCTD13 potassium channel tetramerization domain containing 13
KCTD17 potassium channel tetramerization domain containing 17
KCTD2 potassium channel tetramerization domain containing 2
KCTD5 potassium channel tetramerization domain containing 5
KEAP1 kelch-like ECH-associated protein 1
KIF14 kinesin family member 14
KLHDC2 kelch domain containing 2
KLHDC3 kelch domain containing 3
KLHL1 kelch-like family member 1
KLHL10 kelch-like family member 10
KLHL11 kelch-like family member 11
KLHL12 kelch-like family member 12
KLHL17 kelch-like family member 17
KLHL18 kelch-like family member 18
KLHL2 kelch-like family member 2
KLHL20 kelch-like family member 20
KLHL21 kelch-like family member 21
KLHL22 kelch-like family member 22
KLHL23 kelch-like family member 23
KLHL24 kelch-like family member 24
KLHL28 kelch-like family member 28
KLHL29 kelch-like family member 29
KLHL3 kelch-like family member 3
KLHL30 kelch-like family member 30
KLHL35 kelch-like family member 35
KLHL38 kelch-like family member 38
KLHL4 kelch-like family member 4
KLHL40 kelch-like family member 40
KLHL41 kelch-like family member 41
KLHL42 kelch-like family member 42
KLHL5 kelch-like family member 5
KLHL6 kelch-like family member 6
KLHL7 kelch-like family member 7
KLHL8 kelch-like family member 8
LOC122513141 ring finger protein-like
LRRC75A leucine rich repeat containing 75A
MAEA macrophage erythroblast attacher
MAN1A1 mannosidase, alpha, class 1A, member 1
MAN1A2 mannosidase, alpha, class 1A, member 2
MAN1B1 mannosidase, alpha, class 1B, member 1
MAN1C1 mannosidase, alpha, class 1C, member 1
MARCHF6 membrane associated ring-CH-type finger 6
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MIDN midnolin
MMP1 matrix metallopeptidase 1
MTA1 metastasis associated 1
NCCRP1 non-specific cytotoxic cell receptor protein 1 homolog (zebrafish)
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NFE2L2 nuclear factor, erythroid 2-like 2
NHLRC1 NHL repeat containing E3 ubiquitin protein ligase 1
NHLRC3 NHL repeat containing 3
NPLOC4 nuclear protein localization 4 homolog (S. cerevisiae)
NR1D1 nuclear receptor subfamily 1, group D, member 1
NSFL1C NSFL1 (p97) cofactor (p47)
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin
OTULIN-DT OTULIN divergent transcript
PCBP2 poly(rC) binding protein 2
PCNP PEST proteolytic signal containing nuclear protein
PELI1 pellino E3 ubiquitin protein ligase 1
PEX10 peroxisomal biogenesis factor 10
PEX12 peroxisomal biogenesis factor 12
PJA2 praja ring finger 2, E3 ubiquitin protein ligase
PLAA phospholipase A2-activating protein
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PML promyelocytic leukemia
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma
PRAME preferentially expressed antigen in melanoma
PRAMEF1 PRAME family member 1
PRAMEF10 PRAME family member 10
PRAMEF11 PRAME family member 11
PRAMEF12 PRAME family member 12
PRAMEF13 PRAME family member 13
PRAMEF14 PRAME family member 14
PRAMEF15 PRAME family member 15
PRAMEF17 PRAME family member 17
PRAMEF18 PRAME family member 18
PRAMEF19 PRAME family member 19
PRAMEF2 PRAME family member 2
PRAMEF20 PRAME family member 20
PRAMEF22 PRAME family member 22
PRAMEF26 PRAME family member 26
PRAMEF33 PRAME family member 33
PRAMEF4 PRAME family member 4
PRAMEF5 PRAME family member 5
PRAMEF6 PRAME family member 6
PRAMEF7 PRAME family member 7
PRAMEF8 PRAME family member 8
PRAMEF9 PRAME family member 9
PRKN parkin RBR E3 ubiquitin protein ligase
PROC protein C (inactivator of coagulation factors Va and VIIIa)
PRPF19 pre-mRNA processing factor 19
PSMA1 proteasome (prosome, macropain) subunit, alpha type, 1
PSMA2 proteasome (prosome, macropain) subunit, alpha type, 2
PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3
PSMA4 proteasome (prosome, macropain) subunit, alpha type, 4
PSMA5 proteasome (prosome, macropain) subunit, alpha type, 5
PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7
PSMA8 proteasome (prosome, macropain) subunit, alpha type, 8
PSMB1 proteasome (prosome, macropain) subunit, beta type, 1
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10
PSMB11 proteasome (prosome, macropain) subunit, beta type, 11
PSMB2 proteasome (prosome, macropain) subunit, beta type, 2
PSMB3 proteasome (prosome, macropain) subunit, beta type, 3
PSMB4 proteasome (prosome, macropain) subunit, beta type, 4
PSMB5 proteasome (prosome, macropain) subunit, beta type, 5
PSMB6 proteasome (prosome, macropain) subunit, beta type, 6
PSMB7 proteasome (prosome, macropain) subunit, beta type, 7
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PSMC1 proteasome (prosome, macropain) 26S subunit, ATPase, 1
PSMC2 proteasome (prosome, macropain) 26S subunit, ATPase, 2
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3
PSMC4 proteasome (prosome, macropain) 26S subunit, ATPase, 4
PSMC5 proteasome (prosome, macropain) 26S subunit, ATPase, 5
PSMC6 proteasome (prosome, macropain) 26S subunit, ATPase, 6
PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
PSMD13 proteasome (prosome, macropain) 26S subunit, non-ATPase, 13
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
PSMD3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4
PSMD6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6
PSMD7 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7
PSMD8 proteasome (prosome, macropain) 26S subunit, non-ATPase, 8
PSME4 proteasome (prosome, macropain) activator subunit 4
RAD23A RAD23 homolog A (S. cerevisiae)
RAD23B RAD23 homolog B (S. cerevisiae)
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1
RBX1 ring-box 1, E3 ubiquitin protein ligase
RCN3 reticulocalbin 3, EF-hand calcium binding domain
RFFL ring finger and FYVE-like domain containing E3 ubiquitin protein ligase
RHBDD1 rhomboid domain containing 1
RHBDD2 rhomboid domain containing 2
RHOBTB3 Rho-related BTB domain containing 3
RMND5A required for meiotic nuclear division 5 homolog A (S. cerevisiae)
RMND5B required for meiotic nuclear division 5 homolog B (S. cerevisiae)
RNF103 ring finger protein 103
RNF121 ring finger protein 121
RNF122 ring finger protein 122
RNF126 ring finger protein 126
RNF139 ring finger protein 139
RNF145 ring finger protein 145
RNF175 ring finger protein 175
RNF185 ring finger protein 185
RNF186 ring finger protein 186
RNF187 ring finger protein 187
RNF216 ring finger protein 216
RNF34 ring finger protein 34, E3 ubiquitin protein ligase
RNF4 ring finger protein 4
RNF41 ring finger protein 41, E3 ubiquitin protein ligase
RNF5 ring finger protein 5, E3 ubiquitin protein ligase
RNF7 ring finger protein 7
SEC61B Sec61 beta subunit
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SEL1L2 sel-1 suppressor of lin-12-like 2 (C. elegans)
SELENOS selenoprotein S
SEM1 SEM1 26S proteasome subunit
SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
SH3BGRL SH3 domain binding glutamate-rich protein like
SHARPIN SHANK-associated RH domain interactor
SIAH1 siah E3 ubiquitin protein ligase 1
SIAH2 siah E3 ubiquitin protein ligase 2
SIAH3 siah E3 ubiquitin protein ligase family member 3
SIRT1 sirtuin 1
SIRT2 sirtuin 2
SKP1 S-phase kinase-associated protein 1
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SMURF1 SMAD specific E3 ubiquitin protein ligase 1
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SOCS2 suppressor of cytokine signaling 2
SOCS4 suppressor of cytokine signaling 4
SOCS6 suppressor of cytokine signaling 6
SPATA5L1 spermatogenesis associated 5-like 1
SPOP speckle-type POZ protein
SPOPL speckle-type POZ protein-like
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1
SPSB2 splA/ryanodine receptor domain and SOCS box containing 2
SPSB3 splA/ryanodine receptor domain and SOCS box containing 3
SPSB4 splA/ryanodine receptor domain and SOCS box containing 4
STT3B STT3B, subunit of the oligosaccharyltransferase complex (catalytic)
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
SYVN1 synovial apoptosis inhibitor 1, synoviolin
TBL1X transducin (beta)-like 1X-linked
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TBX21 T-box 21
TMEM129 transmembrane protein 129, E3 ubiquitin protein ligase
TMEM67 transmembrane protein 67
TMUB1 transmembrane and ubiquitin-like domain containing 1
TMUB2 transmembrane and ubiquitin-like domain containing 2
TNFAIP1 tumor necrosis factor, alpha-induced protein 1 (endothelial)
TOPORS topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase
TOR1A torsin family 1, member A (torsin A)
TRIM13 tripartite motif containing 13
TRIM2 tripartite motif containing 2
TRIM21 tripartite motif containing 21
TRIM25 tripartite motif containing 25
TRIM26 tripartite motif containing 26
TRIM28 tripartite motif containing 28
TRIM3 tripartite motif containing 3
TRIM45 tripartite motif containing 45
TRIM71 tripartite motif containing 71, E3 ubiquitin protein ligase
TRIM72 tripartite motif containing 72, E3 ubiquitin protein ligase
TRIM9 tripartite motif containing 9
TRIP12 thyroid hormone receptor interactor 12
UBE2A ubiquitin-conjugating enzyme E2A
UBE2B ubiquitin-conjugating enzyme E2B
UBE2C ubiquitin-conjugating enzyme E2C
UBE2D1 ubiquitin-conjugating enzyme E2D 1
UBE2D3 ubiquitin-conjugating enzyme E2D 3
UBE2G1 ubiquitin-conjugating enzyme E2G 1
UBE2G2 ubiquitin-conjugating enzyme E2G 2
UBE2J1 ubiquitin-conjugating enzyme E2, J1
UBE2J2 ubiquitin-conjugating enzyme E2, J2
UBE2N ubiquitin-conjugating enzyme E2N
UBE2S ubiquitin-conjugating enzyme E2S
UBE2U ubiquitin-conjugating enzyme E2U (putative)
UBE2W ubiquitin-conjugating enzyme E2W (putative)
UBE3A ubiquitin protein ligase E3A
UBE3D ubiquitin protein ligase E3D
UBE4A ubiquitination factor E4A
UBE4B ubiquitination factor E4B
UBQLN1 ubiquilin 1
UBQLN2 ubiquilin 2
UBR1 ubiquitin protein ligase E3 component n-recognin 1
UBR2 ubiquitin protein ligase E3 component n-recognin 2
UBR4 ubiquitin protein ligase E3 component n-recognin 4
UBR5 ubiquitin protein ligase E3 component n-recognin 5
UBXN1 UBX domain protein 1
UBXN10 UBX domain protein 10
UBXN11 UBX domain protein 11
UBXN2A UBX domain protein 2A
UBXN2B UBX domain protein 2B
UBXN4 UBX domain protein 4
UBXN6 UBX domain protein 6
UBXN7 UBX domain protein 7
UBXN8 UBX domain protein 8
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UFD1 ubiquitin recognition factor in ER associated degradation 1
USP19 ubiquitin specific peptidase 19
USP44 ubiquitin specific peptidase 44
UXT ubiquitously-expressed, prefoldin-like chaperone
VCP valosin containing protein
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
WDR26 WD repeat domain 26
WFS1 Wolfram syndrome 1 (wolframin)
WWP1 WW domain containing E3 ubiquitin protein ligase 1
WWP2 WW domain containing E3 ubiquitin protein ligase 2
XBP1 X-box binding protein 1
YOD1 YOD1 deubiquitinase
ZFAND2A zinc finger, AN1-type domain 2A
ZFAND2B zinc finger, AN1-type domain 2B
ZNRF1 zinc and ring finger 1, E3 ubiquitin protein ligase
ZNRF2 zinc and ring finger 2, E3 ubiquitin protein ligase
ZNRF4 zinc and ring finger 4
ZSWIM8 zinc finger, SWIM-type containing 8