protein catabolic process Gene Set

Dataset GO Biological Process Annotations 2025
Category structural or functional annotations
Type biological process
Description The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. (Gene Ontology, GO_0030163)
External Link http://amigo.geneontology.org/amigo/term/GO:0030163
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Genes

108 genes participating in the protein catabolic process biological process from the curated GO Biological Process Annotations 2025 dataset.

Symbol Name
ACD adrenocortical dysplasia homolog (mouse)
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12
ADAMTS7 ADAM metallopeptidase with thrombospondin type 1 motif, 7
AFG1L AFG1 like ATPase
AFG3L2 AFG3-like AAA ATPase 2
APOC2 apolipoprotein C-II
ATE1 arginyltransferase 1
BAG6 BCL2-associated athanogene 6
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
CAPN2 calpain 2, (m/II) large subunit
CAPN3 calpain 3, (p94)
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP7 caspase 7, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CELA2A chymotrypsin-like elastase family, member 2A
CHEK2 checkpoint kinase 2
CLN5 ceroid-lipofuscinosis, neuronal 5
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant
CLN8 ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation)
CLPP caseinolytic mitochondrial matrix peptidase proteolytic subunit
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit
CPA2 carboxypeptidase A2 (pancreatic)
CTRL chymotrypsin-like
CTSB cathepsin B
CTSC cathepsin C
CTSD cathepsin D
CTSF cathepsin F
CTSH cathepsin H
CTSK cathepsin K
CTSL cathepsin L
CTSO cathepsin O
CTSS cathepsin S
CTSV cathepsin V
CTSW cathepsin W
CTSZ cathepsin Z
CUL4B cullin 4B
DAB2IP DAB2 interacting protein
DDB1 damage-specific DNA binding protein 1, 127kDa
DDI1 DNA-damage inducible 1 homolog 1 (S. cerevisiae)
DDI2 DNA-damage inducible 1 homolog 2 (S. cerevisiae)
DENND3 DENN/MADD domain containing 3
DTX4 deltex 4, E3 ubiquitin ligase
ELANE elastase, neutrophil expressed
FBXO17 F-box protein 17
FBXO2 F-box protein 2
FBXO27 F-box protein 27
FBXO44 F-box protein 44
FBXO6 F-box protein 6
GLB1 galactosidase, beta 1
GLMN glomulin, FKBP associated protein
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPA8 heat shock 70kDa protein 8
HTRA2 HtrA serine peptidase 2
IDE insulin-degrading enzyme
LAMP2 lysosomal-associated membrane protein 2
LGMN legumain
LONP1 lon peptidase 1, mitochondrial
LRSAM1 leucine rich repeat and sterile alpha motif containing 1
MAGEA2 melanoma antigen family A2
MAGEC2 melanoma antigen family C2
MALT1 MALT1 paracaspase
MANBA mannosidase, beta A, lysosomal
MARCHF6 membrane associated ring-CH-type finger 6
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MMP14 matrix metallopeptidase 14 (membrane-inserted)
NCCRP1 non-specific cytotoxic cell receptor protein 1 homolog (zebrafish)
NEU2 sialidase 2 (cytosolic sialidase)
NEU4 sialidase 4
NGLY1 N-glycanase 1
NR1D1 nuclear receptor subfamily 1, group D, member 1
OGA O-GlcNAcase
PCSK9 proprotein convertase subtilisin/kexin type 9
PISD phosphatidylserine decarboxylase
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPT1 palmitoyl-protein thioesterase 1
PRKCA protein kinase C, alpha
PRKN parkin RBR E3 ubiquitin protein ligase
PRPF19 pre-mRNA processing factor 19
PRSS16 protease, serine, 16 (thymus)
PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6
PSMA8 proteasome (prosome, macropain) subunit, alpha type, 8
PSMB1 proteasome (prosome, macropain) subunit, beta type, 1
RAB12 RAB12, member RAS oncogene family
RAB7A RAB7A, member RAS oncogene family
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
RNF123 ring finger protein 123
RNF41 ring finger protein 41, E3 ubiquitin protein ligase
RNF5 ring finger protein 5, E3 ubiquitin protein ligase
RSPRY1 ring finger and SPRY domain containing 1
SIAH1 siah E3 ubiquitin protein ligase 1
SLC6A7 solute carrier family 6 (neurotransmitter transporter), member 7
SOCS6 suppressor of cytokine signaling 6
SPATA18 spermatogenesis associated 18
SQSTM1 sequestosome 1
STT3B STT3B, subunit of the oligosaccharyltransferase complex (catalytic)
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
TRIM21 tripartite motif containing 21
TRIM24 tripartite motif containing 24
UBE2Z ubiquitin-conjugating enzyme E2Z
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
UTP25 UTP25 small subunit processome component
VCP valosin containing protein
YME1L1 YME1-like 1 ATPase