protein heterodimerization activity Gene Set

Dataset GO Molecular Function Annotations 2025
Category structural or functional annotations
Type molecular function
Description Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer. (Gene Ontology, GO_0046982)
External Link http://amigo.geneontology.org/amigo/term/GO:0046982
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Genes

217 genes performing the protein heterodimerization activity molecular function from the curated GO Molecular Function Annotations 2025 dataset.

Symbol Name
ABCD2 ATP-binding cassette, sub-family D (ALD), member 2
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ABCG4 ATP-binding cassette, sub-family G (WHITE), member 4
ABCG5 ATP-binding cassette, sub-family G (WHITE), member 5
ABCG8 ATP-binding cassette, sub-family G (WHITE), member 8
ADCY8 adenylate cyclase 8 (brain)
ADD1 adducin 1 (alpha)
ADD2 adducin 2 (beta)
ADRA1A adrenoceptor alpha 1A
ADRA1B adrenoceptor alpha 1B
ADRA2A adrenoceptor alpha 2A
ADRA2C adrenoceptor alpha 2C
ADRB1 adrenoceptor beta 1
AGTR1 angiotensin II receptor, type 1
AHR aryl hydrocarbon receptor
AOC3 amine oxidase, copper containing 3
APOA2 apolipoprotein A-II
APP amyloid beta (A4) precursor protein
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
ATF6 activating transcription factor 6
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP1B2 ATPase, Na+/K+ transporting, beta 2 polypeptide
AURKA aurora kinase A
BAK1 BCL2-antagonist/killer 1
BARD1 BRCA1 associated RING domain 1
BAX BCL2-associated X protein
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BCL2 B-cell CLL/lymphoma 2
BDKRB2 bradykinin receptor B2
BHLHA9 basic helix-loop-helix family, member a9
BHLHE40 basic helix-loop-helix family, member e40
BHLHE41 basic helix-loop-helix family, member e41
BIRC5 baculoviral IAP repeat containing 5
BMP6 bone morphogenetic protein 6
BOK BCL2-related ovarian killer
BUD23 BUD23 rRNA methyltransferase and ribosome maturation factor
CCDC169-SOHLH2 CCDC169-SOHLH2 readthrough
CD247 CD247 molecule
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEACAM8 carcinoembryonic antigen-related cell adhesion molecule 8
CFHR5 complement factor H-related 5
CHUK conserved helix-loop-helix ubiquitous kinase
CLU clusterin
CREB3L3 cAMP responsive element binding protein 3-like 3
CYBA cytochrome b-245, alpha polypeptide
CYBB cytochrome b-245, beta polypeptide
DDIT3 DNA-damage-inducible transcript 3
DGKD diacylglycerol kinase, delta 130kDa
EPAS1 endothelial PAS domain protein 1
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
EXT1 exostosin glycosyltransferase 1
EXT2 exostosin glycosyltransferase 2
FBXO7 F-box protein 7
FMR1 fragile X mental retardation 1
FXR1 fragile X mental retardation, autosomal homolog 1
FXR2 fragile X mental retardation, autosomal homolog 2
FZD4 frizzled class receptor 4
FZD9 frizzled class receptor 9
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GCA grancalcin, EF-hand calcium binding protein
GPHA2 glycoprotein hormone alpha 2
GPHB5 glycoprotein hormone beta 5
GTF2A1 general transcription factor IIA, 1, 19/37kDa
GTF2A2 general transcription factor IIA, 2, 12kDa
HEXA hexosaminidase A (alpha polypeptide)
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HIP1 huntingtin interacting protein 1
HNF1A HNF1 homeobox A
HSF1 heat shock transcription factor 1
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
IKZF3 IKAROS family zinc finger 3 (Aiolos)
IL12A interleukin 12A
IL12B interleukin 12B
IRAK1 interleukin-1 receptor-associated kinase 1
IRAK2 interleukin-1 receptor-associated kinase 2
IRAK3 interleukin-1 receptor-associated kinase 3
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
KATNA1 katanin p60 (ATPase containing) subunit A 1
KATNB1 katanin p80 (WD repeat containing) subunit B 1
KCNB1 potassium channel, voltage gated Shab related subfamily B, member 1
KCNB2 potassium channel, voltage gated Shab related subfamily B, member 2
KCNK1 potassium channel, two pore domain subfamily K, member 1
KCNK12 potassium channel, two pore domain subfamily K, member 12
KCNK13 potassium channel, two pore domain subfamily K, member 13
KCNK16 potassium channel, two pore domain subfamily K, member 16
KCNK17 potassium channel, two pore domain subfamily K, member 17
KCNK2 potassium channel, two pore domain subfamily K, member 2
KCNK3 potassium channel, two pore domain subfamily K, member 3
KCNK5 potassium channel, two pore domain subfamily K, member 5
KCNK9 potassium channel, two pore domain subfamily K, member 9
KRT1 keratin 1, type II
KRT10 keratin 10, type I
KRT25 keratin 25, type I
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MCL1 myeloid cell leukemia 1
MEF2A myocyte enhancer factor 2A
MEF2C myocyte enhancer factor 2C
METTL3 methyltransferase like 3
MIA3 melanoma inhibitory activity family, member 3
MICU1 mitochondrial calcium uptake 1
MICU2 mitochondrial calcium uptake 2
MICU3 mitochondrial calcium uptake family, member 3
MIGA1 mitoguardin 1
MIGA2 mitoguardin 2
MLXIPL MLX interacting protein-like
MTTP microsomal triglyceride transfer protein
NAE1 NEDD8 activating enzyme E1 subunit 1
NEUROD1 neuronal differentiation 1
NEUROD2 neuronal differentiation 2
NFE2L1 nuclear factor, erythroid 2-like 1
NOLC1 nucleolar and coiled-body phosphoprotein 1
NPAS1 neuronal PAS domain protein 1
NPAS3 neuronal PAS domain protein 3
NPAS4 neuronal PAS domain protein 4
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
P4HB prolyl 4-hydroxylase, beta polypeptide
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
PDCD6 programmed cell death 6
PDGFA platelet-derived growth factor alpha polypeptide
PDGFB platelet-derived growth factor beta polypeptide
PEF1 penta-EF-hand domain containing 1
PGLYRP3 peptidoglycan recognition protein 3
PGLYRP4 peptidoglycan recognition protein 4
PHB1 prohibitin 1
PHB2 prohibitin 2
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PML promyelocytic leukemia
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha
PRMT5 protein arginine methyltransferase 5
PSMF1 proteasome (prosome, macropain) inhibitor subunit 1 (PI31)
QTRT1 queuine tRNA-ribosyltransferase 1
QTRT2 queuine tRNA-ribosyltransferase accessory subunit 2
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic)
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic)
RALGAPB Ral GTPase activating protein, beta subunit (non-catalytic)
RAN RAN, member RAS oncogene family
RCC1 regulator of chromosome condensation 1
ROPN1B rhophilin associated tail protein 1B
RRAGA Ras-related GTP binding A
RRAGC Ras-related GTP binding C
RRAGD Ras-related GTP binding D
RUNX1 runt-related transcription factor 1
SAE1 SUMO1 activating enzyme subunit 1
SDCBP syndecan binding protein (syntenin)
SDCBP2 syndecan binding protein (syntenin) 2
SEPHS1 selenophosphate synthetase 1
SIM1 single-minded family bHLH transcription factor 1
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC51A solute carrier family 51, alpha subunit
SLC51B solute carrier family 51, beta subunit
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SLC7A9 solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9
SMC1A structural maintenance of chromosomes 1A
SMC3 structural maintenance of chromosomes 3
SNX1 sorting nexin 1
SNX2 sorting nexin 2
SOHLH1 spermatogenesis and oogenesis specific basic helix-loop-helix 1
SRGAP2C SLIT-ROBO Rho GTPase activating protein 2C
SRI sorcin
SUPT4H1 suppressor of Ty 4 homolog 1 (S. cerevisiae)
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae)
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa
TAF7 TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa
TCF7L1 transcription factor 7-like 1 (T-cell specific, HMG-box)
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TCOF1 Treacher Collins-Franceschetti syndrome 1
TENM1 teneurin transmembrane protein 1
TENM2 teneurin transmembrane protein 2
TENM3 teneurin transmembrane protein 3
TENM4 teneurin transmembrane protein 4
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TLR4 toll-like receptor 4
TLR6 toll-like receptor 6
TOP2A topoisomerase (DNA) II alpha 170kDa
TP53 tumor protein p53
TPM1 tropomyosin 1 (alpha)
TPM2 tropomyosin 2 (beta)
TPM4 tropomyosin 4
TRMT112 tRNA methyltransferase 11-2 homolog (S. cerevisiae)
TUBB2B tubulin, beta 2B class IIb
UBA2 ubiquitin-like modifier activating enzyme 2
UBA3 ubiquitin-like modifier activating enzyme 3
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1
UGT1A10 UDP glucuronosyltransferase 1 family, polypeptide A10
UGT1A3 UDP glucuronosyltransferase 1 family, polypeptide A3
UGT1A4 UDP glucuronosyltransferase 1 family, polypeptide A4
UGT1A6 UDP glucuronosyltransferase 1 family, polypeptide A6
UGT1A7 UDP glucuronosyltransferase 1 family, polypeptide A7
UGT1A8 UDP glucuronosyltransferase 1 family, polypeptide A8
UGT1A9 UDP glucuronosyltransferase 1 family, polypeptide A9
USF1 upstream transcription factor 1
USF2 upstream transcription factor 2, c-fos interacting
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa
VAPB VAMP (vesicle-associated membrane protein)-associated protein B and C
XBP1 X-box binding protein 1
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
ZBTB1 zinc finger and BTB domain containing 1
ZHX1 zinc fingers and homeoboxes 1
ZHX2 zinc fingers and homeoboxes 2
ZHX3 zinc fingers and homeoboxes 3
ZNF396 zinc finger protein 396
ZNF397 zinc finger protein 397