protein processing Gene Set

Dataset GO Biological Process Annotations 2025
Category structural or functional annotations
Type biological process
Description Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein. (Gene Ontology, GO_0016485)
External Link http://amigo.geneontology.org/amigo/term/GO:0016485
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Genes

116 genes participating in the protein processing biological process from the curated GO Biological Process Annotations 2025 dataset.

Symbol Name
ACTMAP actin maturation protease
ADAM10 ADAM metallopeptidase domain 10
ADAM17 ADAM metallopeptidase domain 17
ADAM19 ADAM metallopeptidase domain 19
ADAM9 ADAM metallopeptidase domain 9
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13
ADAMTS3 ADAM metallopeptidase with thrombospondin type 1 motif, 3
AEBP1 AE binding protein 1
AFG3L2 AFG3-like AAA ATPase 2
APH1A APH1A gamma secretase subunit
APH1B APH1B gamma secretase subunit
ASPRV1 aspartic peptidase, retroviral-like 1
ATG4A autophagy related 4A, cysteine peptidase
ATG4B autophagy related 4B, cysteine peptidase
ATG4C autophagy related 4C, cysteine peptidase
ATG4D autophagy related 4D, cysteine peptidase
ATP23 ATP23 metallopeptidase and ATP synthase assembly factor homolog
BACE1 beta-site APP-cleaving enzyme 1
BACE2 beta-site APP-cleaving enzyme 2
BMP1 bone morphogenetic protein 1
C1R complement component 1, r subcomponent
C1RL complement component 1, r subcomponent-like
CASP1 caspase 1, apoptosis-related cysteine peptidase
CASP2 caspase 2, apoptosis-related cysteine peptidase
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP4 caspase 4, apoptosis-related cysteine peptidase
CASP6 caspase 6, apoptosis-related cysteine peptidase
CLN3 ceroid-lipofuscinosis, neuronal 3
CLN5 ceroid-lipofuscinosis, neuronal 5
CPE carboxypeptidase E
CPM carboxypeptidase M
CPNE1 copine I
CPZ carboxypeptidase Z
CSTL1 cystatin-like 1
CTSG cathepsin G
CTSH cathepsin H
CTSL cathepsin L
CTSS cathepsin S
DDI2 DNA-damage inducible 1 homolog 2 (S. cerevisiae)
DLC1 DLC1 Rho GTPase activating protein
ECE1 endothelin converting enzyme 1
ECEL1 endothelin converting enzyme-like 1
EEF1AKMT4-ECE2 EEF1AKMT4-ECE2 readthrough
F12 coagulation factor XII (Hageman factor)
F3 coagulation factor III (thromboplastin, tissue factor)
F7 coagulation factor VII (serum prothrombin conversion accelerator)
F9 coagulation factor IX
FAM111A family with sequence similarity 111, member A
FURIN furin (paired basic amino acid cleaving enzyme)
FXN frataxin
GGT1 gamma-glutamyltransferase 1
HGFAC HGF activator
HJV hemojuvelin BMP co-receptor
HM13 histocompatibility (minor) 13
HOMER2 homer scaffolding protein 2
HPR haptoglobin-related protein
HTRA2 HtrA serine peptidase 2
IMMP1L IMP1 inner mitochondrial membrane peptidase-like (S. cerevisiae)
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae)
KEL Kell blood group, metallo-endopeptidase
KLK1 kallikrein 1
KLK2 kallikrein-related peptidase 2
KLK6 kallikrein-related peptidase 6
KLKB1 kallikrein B, plasma (Fletcher factor) 1
LGMN legumain
LONP2 lon peptidase 2, peroxisomal
MBTPS1 membrane-bound transcription factor peptidase, site 1
MEP1A meprin A, alpha (PABA peptide hydrolase)
METAP2 methionyl aminopeptidase 2
MMEL1 membrane metallo-endopeptidase-like 1
MMP12 matrix metallopeptidase 12
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MMP16 matrix metallopeptidase 16 (membrane-inserted)
MYRF myelin regulatory factor
MYRFL myelin regulatory factor-like
NCSTN nicastrin
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
OMA1 OMA1 zinc metallopeptidase
PARL presenilin associated, rhomboid-like
PCSK4 proprotein convertase subtilisin/kexin type 4
PCSK5 proprotein convertase subtilisin/kexin type 5
PCSK6 proprotein convertase subtilisin/kexin type 6
PCSK7 proprotein convertase subtilisin/kexin type 7
PCSK9 proprotein convertase subtilisin/kexin type 9
PHEX phosphate regulating endopeptidase homolog, X-linked
PIDD1 p53-induced death domain protein 1
PITRM1 pitrilysin metallopeptidase 1
PRSS3 protease, serine, 3
PSEN1 presenilin 1
PSEN2 presenilin 2
PSENEN presenilin enhancer gamma secretase subunit
PTCH1 patched 1
RCE1 Ras converting CAAX endopeptidase 1
SDE2 SDE2 telomere maintenance homolog (S. pombe)
SEC11A SEC11 homolog A (S. cerevisiae)
SEC11C SEC11 homolog C (S. cerevisiae)
SPCS1 signal peptidase complex subunit 1 homolog (S. cerevisiae)
SPCS2 signal peptidase complex subunit 2 homolog (S. cerevisiae)
SPCS3 signal peptidase complex subunit 3 homolog (S. cerevisiae)
SPG7 spastic paraplegia 7 (pure and complicated autosomal recessive)
SPPL3 signal peptide peptidase like 3
SPRTN SprT-like N-terminal domain
SRGN serglycin
STOML2 stomatin (EPB72)-like 2
THBD thrombomodulin
TLL1 tolloid-like 1
TLL2 tolloid-like 2
TMEM208 transmembrane protein 208
TMPRSS2 transmembrane protease, serine 2
TMPRSS4 transmembrane protease, serine 4
TYSND1 trypsin domain containing 1
USP17L2 ubiquitin specific peptidase 17-like family member 2
VSIR V-set immunoregulatory receptor
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial
YME1L1 YME1-like 1 ATPase
ZMPSTE24 zinc metallopeptidase STE24