protein-glutamine gamma-glutamyltransferase activity Gene Set

Dataset GO Molecular Function Annotations
Category structural or functional annotations
Type molecular function
Description Catalysis of the reaction: protein glutamine + alkylamine = protein N5-alkylglutamine + NH3. This reaction is the formation of the N6-(L-isoglutamyl)-L-lysine isopeptide, resulting in cross-linking polypeptide chains; the gamma-carboxamide groups of peptidyl-glutamine residues act as acyl donors, and the 6-amino-groups of peptidyl-lysine residues act as acceptors, to give intra- and intermolecular N6-(5-glutamyl)lysine cross-links. (Gene Ontology, GO_0003810)
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9 genes performing the protein-glutamine gamma-glutamyltransferase activity molecular function from the curated GO Molecular Function Annotations dataset.

Symbol Name
EPB42 erythrocyte membrane protein band 4.2
F13A1 coagulation factor XIII, A1 polypeptide
TGM1 transglutaminase 1
TGM2 transglutaminase 2
TGM3 transglutaminase 3
TGM4 transglutaminase 4
TGM5 transglutaminase 5
TGM6 transglutaminase 6
TGM7 transglutaminase 7