proteolysis Gene Set

Dataset GO Biological Process Annotations 2025
Category structural or functional annotations
Type biological process
Description The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. (Gene Ontology, GO_0006508)
External Link http://amigo.geneontology.org/amigo/term/GO:0006508
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Genes

322 genes participating in the proteolysis biological process from the curated GO Biological Process Annotations 2025 dataset.

Symbol Name
ACAN aggrecan
ACD adrenocortical dysplasia homolog (mouse)
ACE angiotensin I converting enzyme
ACTMAP actin maturation protease
ADAM10 ADAM metallopeptidase domain 10
ADAM11 ADAM metallopeptidase domain 11
ADAM12 ADAM metallopeptidase domain 12
ADAM15 ADAM metallopeptidase domain 15
ADAM17 ADAM metallopeptidase domain 17
ADAM18 ADAM metallopeptidase domain 18
ADAM19 ADAM metallopeptidase domain 19
ADAM2 ADAM metallopeptidase domain 2
ADAM20 ADAM metallopeptidase domain 20
ADAM21 ADAM metallopeptidase domain 21
ADAM22 ADAM metallopeptidase domain 22
ADAM23 ADAM metallopeptidase domain 23
ADAM28 ADAM metallopeptidase domain 28
ADAM29 ADAM metallopeptidase domain 29
ADAM30 ADAM metallopeptidase domain 30
ADAM32 ADAM metallopeptidase domain 32
ADAM33 ADAM metallopeptidase domain 33
ADAM7 ADAM metallopeptidase domain 7
ADAM8 ADAM metallopeptidase domain 8
ADAM9 ADAM metallopeptidase domain 9
ADAMDEC1 ADAM-like, decysin 1
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADAMTS10 ADAM metallopeptidase with thrombospondin type 1 motif, 10
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13
ADAMTS14 ADAM metallopeptidase with thrombospondin type 1 motif, 14
ADAMTS15 ADAM metallopeptidase with thrombospondin type 1 motif, 15
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16
ADAMTS17 ADAM metallopeptidase with thrombospondin type 1 motif, 17
ADAMTS18 ADAM metallopeptidase with thrombospondin type 1 motif, 18
ADAMTS19 ADAM metallopeptidase with thrombospondin type 1 motif, 19
ADAMTS2 ADAM metallopeptidase with thrombospondin type 1 motif, 2
ADAMTS20 ADAM metallopeptidase with thrombospondin type 1 motif, 20
ADAMTS3 ADAM metallopeptidase with thrombospondin type 1 motif, 3
ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif, 4
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6
ADAMTS7 ADAM metallopeptidase with thrombospondin type 1 motif, 7
ADAMTS8 ADAM metallopeptidase with thrombospondin type 1 motif, 8
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9
ADGRV1 adhesion G protein-coupled receptor V1
AEBP1 AE binding protein 1
AFG3L2 AFG3-like AAA ATPase 2
ANPEP alanyl (membrane) aminopeptidase
APEH acylaminoacyl-peptide hydrolase
APH1A APH1A gamma secretase subunit
APH1B APH1B gamma secretase subunit
ASPRV1 aspartic peptidase, retroviral-like 1
ATG4A autophagy related 4A, cysteine peptidase
ATG4B autophagy related 4B, cysteine peptidase
ATG4C autophagy related 4C, cysteine peptidase
ATG4D autophagy related 4D, cysteine peptidase
AZU1 azurocidin 1
BACE1 beta-site APP-cleaving enzyme 1
BACE2 beta-site APP-cleaving enzyme 2
BMP1 bone morphogenetic protein 1
BPNT1 3'(2'), 5'-bisphosphate nucleotidase 1
CAPN1 calpain 1, (mu/I) large subunit
CAPN10 calpain 10
CAPN11 calpain 11
CAPN12 calpain 12
CAPN13 calpain 13
CAPN14 calpain 14
CAPN15 calpain 15
CAPN2 calpain 2, (m/II) large subunit
CAPN3 calpain 3, (p94)
CAPN5 calpain 5
CAPN6 calpain 6
CAPN7 calpain 7
CAPN8 calpain 8
CAPN9 calpain 9
CAPNS1 calpain, small subunit 1
CARD8 caspase recruitment domain family, member 8
CASP1 caspase 1, apoptosis-related cysteine peptidase
CASP2 caspase 2, apoptosis-related cysteine peptidase
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP4 caspase 4, apoptosis-related cysteine peptidase
CASP6 caspase 6, apoptosis-related cysteine peptidase
CASP7 caspase 7, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CELA1 chymotrypsin-like elastase family, member 1
CELA2A chymotrypsin-like elastase family, member 2A
CELA2B chymotrypsin-like elastase family, member 2B
CELA3A chymotrypsin-like elastase family, member 3A
CELA3B chymotrypsin-like elastase family, member 3B
CFH complement factor H
CLN3 ceroid-lipofuscinosis, neuronal 3
CLPP caseinolytic mitochondrial matrix peptidase proteolytic subunit
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit
CNDP1 carnosine dipeptidase 1 (metallopeptidase M20 family)
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family)
COLEC10 collectin sub-family member 10 (C-type lectin)
COLEC11 collectin sub-family member 11
CPA1 carboxypeptidase A1 (pancreatic)
CPA2 carboxypeptidase A2 (pancreatic)
CPA4 carboxypeptidase A4
CPA5 carboxypeptidase A5
CPA6 carboxypeptidase A6
CPB1 carboxypeptidase B1 (tissue)
CPB2 carboxypeptidase B2 (plasma)
CPE carboxypeptidase E
CPM carboxypeptidase M
CPNE1 copine I
CPO carboxypeptidase O
CPQ carboxypeptidase Q
CPZ carboxypeptidase Z
CTRB1 chymotrypsinogen B1
CTRB2 chymotrypsinogen B2
CTRC chymotrypsin C (caldecrin)
CTRL chymotrypsin-like
CTSA cathepsin A
CTSB cathepsin B
CTSC cathepsin C
CTSD cathepsin D
CTSE cathepsin E
CTSF cathepsin F
CTSG cathepsin G
CTSH cathepsin H
CTSK cathepsin K
CTSL cathepsin L
CTSO cathepsin O
CTSS cathepsin S
CTSV cathepsin V
CTSW cathepsin W
CTSZ cathepsin Z
CUL7 cullin 7
DDI2 DNA-damage inducible 1 homolog 2 (S. cerevisiae)
DHH desert hedgehog
DPP3 dipeptidyl-peptidase 3
DPP4 dipeptidyl-peptidase 4
DPP8 dipeptidyl-peptidase 8
DPP9 dipeptidyl-peptidase 9
ECE1 endothelin converting enzyme 1
ECEL1 endothelin converting enzyme-like 1
EEF1AKMT4-ECE2 EEF1AKMT4-ECE2 readthrough
ELANE elastase, neutrophil expressed
ENDOU endonuclease, polyU-specific
ENPEP glutamyl aminopeptidase (aminopeptidase A)
ERAP1 endoplasmic reticulum aminopeptidase 1
ERAP2 endoplasmic reticulum aminopeptidase 2
ERMP1 endoplasmic reticulum metallopeptidase 1
F12 coagulation factor XII (Hageman factor)
F3 coagulation factor III (thromboplastin, tissue factor)
F7 coagulation factor VII (serum prothrombin conversion accelerator)
F9 coagulation factor IX
FAM111A family with sequence similarity 111, member A
FBXL2 F-box and leucine-rich repeat protein 2
FBXL6 F-box and leucine-rich repeat protein 6
FBXO2 F-box protein 2
FBXO3 F-box protein 3
FBXO6 F-box protein 6
FBXW2 F-box and WD repeat domain containing 2
FCN1 ficolin (collagen/fibrinogen domain containing) 1
FCN2 ficolin (collagen/fibrinogen domain containing lectin) 2
FCN3 ficolin (collagen/fibrinogen domain containing) 3
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
FURIN furin (paired basic amino acid cleaving enzyme)
GGT1 gamma-glutamyltransferase 1
GGT5 gamma-glutamyltransferase 5
GLMN glomulin, FKBP associated protein
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
HABP2 hyaluronan binding protein 2
HGFAC HGF activator
HM13 histocompatibility (minor) 13
HOMER2 homer scaffolding protein 2
HPN hepsin
HTRA1 HtrA serine peptidase 1
HTRA2 HtrA serine peptidase 2
HTRA3 HtrA serine peptidase 3
HTRA4 HtrA serine peptidase 4
IDE insulin-degrading enzyme
IHH indian hedgehog
KCTD11 potassium channel tetramerization domain containing 11
KEL Kell blood group, metallo-endopeptidase
KLK12 kallikrein-related peptidase 12
KLK13 kallikrein-related peptidase 13
KLK14 kallikrein-related peptidase 14
KLK4 kallikrein-related peptidase 4
KLKB1 kallikrein B, plasma (Fletcher factor) 1
LACTB lactamase, beta
LAP3 leucine aminopeptidase 3
LCN1 lipocalin 1
LGMN legumain
LNPEP leucyl/cystinyl aminopeptidase
LONP1 lon peptidase 1, mitochondrial
LONP2 lon peptidase 2, peroxisomal
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
LVRN laeverin
MALT1 MALT1 paracaspase
MBL2 mannose-binding lectin (protein C) 2, soluble
MBTPS1 membrane-bound transcription factor peptidase, site 1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
METAP2 methionyl aminopeptidase 2
MMEL1 membrane metallo-endopeptidase-like 1
MMP1 matrix metallopeptidase 1
MMP12 matrix metallopeptidase 12
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MMP15 matrix metallopeptidase 15 (membrane-inserted)
MMP16 matrix metallopeptidase 16 (membrane-inserted)
MMP17 matrix metallopeptidase 17 (membrane-inserted)
MMP19 matrix metallopeptidase 19
MMP2 matrix metallopeptidase 2
MMP24 matrix metallopeptidase 24 (membrane-inserted)
MMP26 matrix metallopeptidase 26
MMP28 matrix metallopeptidase 28
MMP3 matrix metallopeptidase 3
MMP7 matrix metallopeptidase 7
MMP8 matrix metallopeptidase 8
MMP9 matrix metallopeptidase 9
NAALAD2 N-acetylated alpha-linked acidic dipeptidase 2
NAPSA napsin A aspartic peptidase
NCSTN nicastrin
NEDD8 neural precursor cell expressed, developmentally down-regulated 8
NLN neurolysin (metallopeptidase M3 family)
NLRP1 NLR family, pyrin domain containing 1
NPEPL1 aminopeptidase-like 1
NPEPPS aminopeptidase puromycin sensitive
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1
PAPPA pregnancy-associated plasma protein A, pappalysin 1
PAPPA2 pappalysin 2
PARL presenilin associated, rhomboid-like
PCOLCE procollagen C-endopeptidase enhancer
PCSK1 proprotein convertase subtilisin/kexin type 1
PCSK2 proprotein convertase subtilisin/kexin type 2
PCSK4 proprotein convertase subtilisin/kexin type 4
PCSK5 proprotein convertase subtilisin/kexin type 5
PCSK6 proprotein convertase subtilisin/kexin type 6
PCSK7 proprotein convertase subtilisin/kexin type 7
PEPD peptidase D
PGA3 pepsinogen 3, group I (pepsinogen A)
PGA4 pepsinogen 4, group I (pepsinogen A)
PGA5 pepsinogen 5, group I (pepsinogen A)
PGC progastricsin (pepsinogen C)
PHEX phosphate regulating endopeptidase homolog, X-linked
PITRM1 pitrilysin metallopeptidase 1
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PLG plasminogen
PM20D2 peptidase M20 domain containing 2
PROC protein C (inactivator of coagulation factors Va and VIIIa)
PRSS2 protease, serine, 2 (trypsin 2)
PRSS21 protease, serine, 21 (testisin)
PRSS22 protease, serine, 22
PRSS3 protease, serine, 3
PRSS33 protease, serine, 33
PRSS38 protease, serine, 38
PRSS48 protease, serine, 48
PRSS50 protease, serine, 50
PRSS54 protease, serine, 54
PRSS56 protease, serine, 56
PRSS57 protease, serine, 57
PRSS58 protease, serine, 58
PRTN3 proteinase 3
PSEN1 presenilin 1
PSEN2 presenilin 2
PSENEN presenilin enhancer gamma secretase subunit
PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6
PSMB1 proteasome (prosome, macropain) subunit, beta type, 1
PSMB11 proteasome (prosome, macropain) subunit, beta type, 11
PSMB5 proteasome (prosome, macropain) subunit, beta type, 5
PSMC4 proteasome (prosome, macropain) 26S subunit, ATPase, 4
PTCH1 patched 1
RET ret proto-oncogene
RHBDD1 rhomboid domain containing 1
RNF123 ring finger protein 123
RNPEP arginyl aminopeptidase (aminopeptidase B)
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1
RSPRY1 ring finger and SPRY domain containing 1
SDE2 SDE2 telomere maintenance homolog (S. pombe)
SHH sonic hedgehog
SOS1 son of sevenless homolog 1 (Drosophila)
SPCS1 signal peptidase complex subunit 1 homolog (S. cerevisiae)
SPCS3 signal peptidase complex subunit 3 homolog (S. cerevisiae)
SPG7 spastic paraplegia 7 (pure and complicated autosomal recessive)
SPPL2A signal peptide peptidase like 2A
SPPL2B signal peptide peptidase like 2B
SPPL2C signal peptide peptidase like 2C
SPPL3 signal peptide peptidase like 3
SPRTN SprT-like N-terminal domain
SRGN serglycin
ST14 suppression of tumorigenicity 14 (colon carcinoma)
SVBP small vasohibin binding protein
TASP1 taspase, threonine aspartase, 1
TBL1X transducin (beta)-like 1X-linked
THBD thrombomodulin
THOP1 thimet oligopeptidase 1
TINAGL1 tubulointerstitial nephritis antigen-like 1
TLL1 tolloid-like 1
TLL2 tolloid-like 2
TMPRSS11D transmembrane protease, serine 11D
TMPRSS11E transmembrane protease, serine 11E
TMPRSS2 transmembrane protease, serine 2
TMPRSS3 transmembrane protease, serine 3
TMPRSS4 transmembrane protease, serine 4
TMPRSS5 transmembrane protease, serine 5
TMPRSS6 transmembrane protease, serine 6
TMPRSS7 transmembrane protease, serine 7
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TPSD1 tryptase delta 1
TPSG1 tryptase gamma 1
TRABD2A TraB domain containing 2A
TRABD2B TraB domain containing 2B
TRHDE thyrotropin-releasing hormone degrading enzyme
TYSND1 trypsin domain containing 1
UBA3 ubiquitin-like modifier activating enzyme 3
UBD ubiquitin D
UBE3A ubiquitin protein ligase E3A
UFSP2 UFM1-specific peptidase 2
VASH1 vasohibin 1
VASH2 vasohibin 2
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
WFDC2 WAP four-disulfide core domain 2
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial
ZMPSTE24 zinc metallopeptidase STE24