proteolysis Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. (Gene Ontology, GO_0006508)
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Genes

334 genes co-occuring with the biological term proteolysis in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
A2M alpha-2-macroglobulin
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ADAM10 ADAM metallopeptidase domain 10
ADAM17 ADAM metallopeptidase domain 17
ADAM22 ADAM metallopeptidase domain 22
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ADGRE2 adhesion G protein-coupled receptor E2
ADRM1 adhesion regulating molecule 1
AFG3L2 AFG3-like AAA ATPase 2
AGER advanced glycosylation end product-specific receptor
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AKAP10 A kinase (PRKA) anchor protein 10
AKT1S1 AKT1 substrate 1 (proline-rich)
ALCAM activated leukocyte cell adhesion molecule
ANAPC1 anaphase promoting complex subunit 1
ANXA1 annexin A1
APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
APC adenomatous polyposis coli
APH1A APH1A gamma secretase subunit
APOB apolipoprotein B
APP amyloid beta (A4) precursor protein
ATXN3 ataxin 3
AVEN apoptosis, caspase activation inhibitor
B2M beta-2-microglobulin
BCAR1 breast cancer anti-estrogen resistance 1
BLMH bleomycin hydrolase
BRAF B-Raf proto-oncogene, serine/threonine kinase
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
CAMP cathelicidin antimicrobial peptide
CAPN1 calpain 1, (mu/I) large subunit
CAPN2 calpain 2, (m/II) large subunit
CAPN3 calpain 3, (p94)
CASP1 caspase 1, apoptosis-related cysteine peptidase
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP7 caspase 7, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CAST calpastatin
CCNB1 cyclin B1
CCND1 cyclin D1
CCNE1 cyclin E1
CCNF cyclin F
CD40 CD40 molecule, TNF receptor superfamily member 5
CD44 CD44 molecule (Indian blood group)
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CDSN corneodesmosin
CEP250 centrosomal protein 250kDa
CHEK1 checkpoint kinase 1
CHEK2 checkpoint kinase 2
CLEC2A C-type lectin domain family 2, member A
COIL coilin
COMMD1 copper metabolism (Murr1) domain containing 1
COPS5 COP9 signalosome subunit 5
CREB3 cAMP responsive element binding protein 3
CREB3L2 cAMP responsive element binding protein 3-like 2
CREB3L3 cAMP responsive element binding protein 3-like 3
CST3 cystatin C
CST7 cystatin F (leukocystatin)
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTNND1 catenin (cadherin-associated protein), delta 1
CTSD cathepsin D
CTSG cathepsin G
CTSL cathepsin L
CTSS cathepsin S
CTSZ cathepsin Z
CUL4A cullin 4A
CUL4B cullin 4B
CXCL12 chemokine (C-X-C motif) ligand 12
CXCR4 chemokine (C-X-C motif) receptor 4
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DCD dermcidin
DDB1 damage-specific DNA binding protein 1, 127kDa
DDIT4 DNA-damage-inducible transcript 4
DEC1 deleted in esophageal cancer 1
DEFA1B defensin, alpha 1B
DEFB1 defensin, beta 1
DIO2 deiodinase, iodothyronine, type II
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DLL1 delta-like 1 (Drosophila)
DMD dystrophin
DPP4 dipeptidyl-peptidase 4
DST dystonin
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP1 dual specificity phosphatase 1
ECSCR endothelial cell surface expressed chemotaxis and apoptosis regulator
EDNRB endothelin receptor type B
EEF1A1 eukaryotic translation elongation factor 1 alpha 1
EGFR epidermal growth factor receptor
EIF3E eukaryotic translation initiation factor 3, subunit E
EIF4E eukaryotic translation initiation factor 4E
ELANE elastase, neutrophil expressed
ELAVL1 ELAV like RNA binding protein 1
ENG endoglin
EPCAM epithelial cell adhesion molecule
ERBB2 erb-b2 receptor tyrosine kinase 2
ESR1 estrogen receptor 1
F13A1 coagulation factor XIII, A1 polypeptide
F13B coagulation factor XIII, B polypeptide
F2 coagulation factor II (thrombin)
F3 coagulation factor III (thromboplastin, tissue factor)
F5 coagulation factor V (proaccelerin, labile factor)
F8 coagulation factor VIII, procoagulant component
FAM20C family with sequence similarity 20, member C
FBLN1 fibulin 1
FBXO7 F-box protein 7
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FBXW8 F-box and WD repeat domain containing 8
FGF2 fibroblast growth factor 2 (basic)
FGF23 fibroblast growth factor 23
FLNC filamin C, gamma
FN1 fibronectin 1
FOXM1 forkhead box M1
FOXO3 forkhead box O3
FURIN furin (paired basic amino acid cleaving enzyme)
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GAS2L3 growth arrest-specific 2 like 3
GATA6 GATA binding protein 6
GDF2 growth differentiation factor 2
GFAP glial fibrillary acidic protein
GHR growth hormone receptor
GLI1 GLI family zinc finger 1
GLI2 GLI family zinc finger 2
GLI3 GLI family zinc finger 3
GRN granulin
GSK3A glycogen synthase kinase 3 alpha
GSK3B glycogen synthase kinase 3 beta
HABP2 hyaluronan binding protein 2
HDAC1 histone deacetylase 1
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HLA-B major histocompatibility complex, class I, B
HMGB1 high mobility group box 1
HRAS Harvey rat sarcoma viral oncogene homolog
HSPB1 heat shock 27kDa protein 1
HSPB2 heat shock 27kDa protein 2
HSPE1 heat shock 10kDa protein 1
HSPG2 heparan sulfate proteoglycan 2
HTRA2 HtrA serine peptidase 2
HTT huntingtin
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
IDE insulin-degrading enzyme
IFNAR2 interferon (alpha, beta and omega) receptor 2
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2
IGFBP3 insulin-like growth factor binding protein 3
IGFBP4 insulin-like growth factor binding protein 4
IGFBP5 insulin-like growth factor binding protein 5
IGSF1 immunoglobulin superfamily, member 1
IL33 interleukin 33
IL6 interleukin 6
IL6R interleukin 6 receptor
IRF9 interferon regulatory factor 9
IRS1 insulin receptor substrate 1
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
JAG1 jagged 1
JAK2 Janus kinase 2
JPH1 junctophilin 1
JPH2 junctophilin 2
JUNB jun B proto-oncogene
KDR kinase insert domain receptor
KIAA0368 KIAA0368
KLF5 Kruppel-like factor 5 (intestinal)
KLK3 kallikrein-related peptidase 3
KMT2A lysine (K)-specific methyltransferase 2A
KRT8 keratin 8, type II
LIG3 ligase III, DNA, ATP-dependent
LONP1 lon peptidase 1, mitochondrial
LONP2 lon peptidase 2, peroxisomal
LRP1 low density lipoprotein receptor-related protein 1
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
LY96 lymphocyte antigen 96
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPT microtubule-associated protein tau
MARCKS myristoylated alanine-rich protein kinase C substrate
MBL2 mannose-binding lectin (protein C) 2, soluble
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MET MET proto-oncogene, receptor tyrosine kinase
MIR490 microRNA 490
MLH1 mutL homolog 1
MME membrane metallo-endopeptidase
MMP1 matrix metallopeptidase 1
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MMP3 matrix metallopeptidase 3
MMP7 matrix metallopeptidase 7
MMP9 matrix metallopeptidase 9
MSTN myostatin
MUC2 mucin 2, oligomeric mucus/gel-forming
MUC7 mucin 7, secreted
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYOD1 myogenic differentiation 1
NAE1 NEDD8 activating enzyme E1 subunit 1
NCF1 neutrophil cytosolic factor 1
NCOR1 nuclear receptor corepressor 1
NCSTN nicastrin
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NGFR nerve growth factor receptor
NLRP1 NLR family, pyrin domain containing 1
NMRAL1 NmrA-like family domain containing 1
NOTCH1 notch 1
NPEPPS aminopeptidase puromycin sensitive
NPPA natriuretic peptide A
NPR1 natriuretic peptide receptor 1
NPR2 natriuretic peptide receptor 2
NPR3 natriuretic peptide receptor 3
NPSA novel prostate-specific antigen
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NUB1 negative regulator of ubiquitin-like proteins 1
NUP98 nucleoporin 98kDa
OPA1 optic atrophy 1 (autosomal dominant)
OSM oncostatin M
PAH phenylalanine hydroxylase
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PAPPA pregnancy-associated plasma protein A, pappalysin 1
PARK7 parkinson protein 7
PARL presenilin associated, rhomboid-like
PCNA proliferating cell nuclear antigen
PCSK9 proprotein convertase subtilisin/kexin type 9
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PKD1 polycystic kidney disease 1 (autosomal dominant)
PLAT plasminogen activator, tissue
PLAUR plasminogen activator, urokinase receptor
PLG plasminogen
PLK1 polo-like kinase 1
PML promyelocytic leukemia
POLQ polymerase (DNA directed), theta
PPARG peroxisome proliferator-activated receptor gamma
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PREP prolyl endopeptidase
PRKD1 protein kinase D1
PRSS12 protease, serine, 12 (neurotrypsin, motopsin)
PSEN1 presenilin 1
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4
PSMD7 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7
PSME3 proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTK2 protein tyrosine kinase 2
PTK7 protein tyrosine kinase 7 (inactive)
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PTPRM protein tyrosine phosphatase, receptor type, M
PXN paxillin
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAD17 RAD17 homolog (S. pombe)
RAD21 RAD21 homolog (S. pombe)
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RARA retinoic acid receptor, alpha
RBL2 retinoblastoma-like 2
RBP3 retinol binding protein 3, interstitial
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
REST RE1-silencing transcription factor
RFWD2 ring finger and WD repeat domain 2, E3 ubiquitin protein ligase
RPA1 replication protein A1, 70kDa
RPS2 ribosomal protein S2
RTN4R reticulon 4 receptor
SENP8 SUMO/sentrin specific peptidase family member 8
SERPINA7 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SETD8 SET domain containing (lysine methyltransferase) 8
SFTPD surfactant protein D
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SHH sonic hedgehog
SKI SKI proto-oncogene
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal
SOCS6 suppressor of cytokine signaling 6
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPINT1 serine peptidase inhibitor, Kunitz type 1
SPN sialophorin
SPPL2A signal peptide peptidase like 2A
SPPL2B signal peptide peptidase like 2B
SPTAN1 spectrin, alpha, non-erythrocytic 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SSRP1 structure specific recognition protein 1
ST14 suppression of tumorigenicity 14 (colon carcinoma)
STAR steroidogenic acute regulatory protein
STAT2 signal transducer and activator of transcription 2, 113kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STEAP3 STEAP family member 3, metalloreductase
TFRC transferrin receptor
TGFA transforming growth factor, alpha
TGFB1 transforming growth factor, beta 1
TGM2 transglutaminase 2
THYN1 thymocyte nuclear protein 1
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM106B transmembrane protein 106B
TNF tumor necrosis factor
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b
TNNI3 troponin I type 3 (cardiac)
TP53 tumor protein p53
TPI1 triosephosphate isomerase 1
TPO thyroid peroxidase
TRIM25 tripartite motif containing 25
TRIM28 tripartite motif containing 28
TSPAN12 tetraspanin 12
TTR transthyretin
TXNL1 thioredoxin-like 1
TYK2 tyrosine kinase 2
TYMS thymidylate synthetase
UBA2 ubiquitin-like modifier activating enzyme 2
UBC ubiquitin C
UBD ubiquitin D
UBE3A ubiquitin protein ligase E3A
UBQLN2 ubiquilin 2
UCHL5 ubiquitin carboxyl-terminal hydrolase L5
UNG uracil-DNA glycosylase
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)
USP17L9P ubiquitin specific peptidase 17-like family member 9, pseudogene
USP18 ubiquitin specific peptidase 18
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
UTRN utrophin
VAV1 vav 1 guanine nucleotide exchange factor
VCAN versican
VCP valosin containing protein
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
VLDLR very low density lipoprotein receptor
VWF von Willebrand factor
WT1 Wilms tumor 1
WWP1 WW domain containing E3 ubiquitin protein ligase 1
XPC xeroderma pigmentosum, complementation group C
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
YY1 YY1 transcription factor