proteolysis Gene Set

Dataset Phosphosite Textmining Biological Term Annotations
Category structural or functional annotations
Type biological term
Description The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. (Gene Ontology, GO_0006508)
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Genes

223 proteins co-occuring with the biological term proteolysis in abstracts of publications describing phosphosites from the Phosphosite Textmining Biological Term Annotations dataset.

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ACO1 aconitase 1, soluble
ADD1 adducin 1 (alpha)
ADRBK1 adrenergic, beta, receptor kinase 1
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALDOA aldolase A, fructose-bisphosphate
ALDOB aldolase B, fructose-bisphosphate
ANXA2 annexin A2
APP amyloid beta (A4) precursor protein
AR androgen receptor
ATM ATM serine/threonine kinase
ATP7B ATPase, Cu++ transporting, beta polypeptide
AURKA aurora kinase A
BBC3 BCL2 binding component 3
BIK BCL2-interacting killer (apoptosis-inducing)
BLK BLK proto-oncogene, Src family tyrosine kinase
BLNK B-cell linker
BORA bora, aurora kinase A activator
BRCA1 breast cancer 1, early onset
CALD1 caldesmon 1
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CCDC6 coiled-coil domain containing 6
CCNA2 cyclin A2
CCND1 cyclin D1
CCNE1 cyclin E1
CCNE2 cyclin E2
CD34 CD34 molecule
CD44 CD44 molecule (Indian blood group)
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CDC6 cell division cycle 6
CDCA8 cell division cycle associated 8
CDK1 cyclin-dependent kinase 1
CDK10 cyclin-dependent kinase 10
CDK2 cyclin-dependent kinase 2
CDK5 cyclin-dependent kinase 5
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CDT1 chromatin licensing and DNA replication factor 1
CFLAR CASP8 and FADD-like apoptosis regulator
CHEK1 checkpoint kinase 1
CHEK2 checkpoint kinase 2
CHGA chromogranin A
CHRNG cholinergic receptor, nicotinic, gamma (muscle)
CHUK conserved helix-loop-helix ubiquitous kinase
CLSPN claspin
CREB1 cAMP responsive element binding protein 1
CREBBP CREB binding protein
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTNND2 catenin (cadherin-associated protein), delta 2
DCLK1 doublecortin-like kinase 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DPYSL2 dihydropyrimidinase-like 2
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP1 dual specificity phosphatase 1
DUSP6 dual specificity phosphatase 6
EEF2 eukaryotic translation elongation factor 2
EEF2K eukaryotic elongation factor 2 kinase
EGFR epidermal growth factor receptor
EIF4E eukaryotic translation initiation factor 4E
ELAVL1 ELAV like RNA binding protein 1
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
ELF4 E74-like factor 4 (ets domain transcription factor)
EP300 E1A binding protein p300
ERBB2 erb-b2 receptor tyrosine kinase 2
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
ESR2 estrogen receptor 2 (ER beta)
FBP1 fructose-1,6-bisphosphatase 1
FBXO31 F-box protein 31
FBXW8 F-box and WD repeat domain containing 8
FOXC1 forkhead box C1
FOXO1 forkhead box O1
FOXO3 forkhead box O3
FRS2 fibroblast growth factor receptor substrate 2
FUS FUS RNA binding protein
GAP43 growth associated protein 43
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GPSM3 G-protein signaling modulator 3
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B
GRK1 G protein-coupled receptor kinase 1
GSK3A glycogen synthase kinase 3 alpha
GSK3B glycogen synthase kinase 3 beta
GTF2IRD1 GTF2I repeat domain containing 1
H2AFX H2A histone family, member X
HIST1H3A histone cluster 1, H3a
HLA-A major histocompatibility complex, class I, A
HLA-B major histocompatibility complex, class I, B
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1
HSPB1 heat shock 27kDa protein 1
HSPB6 heat shock protein, alpha-crystallin-related, B6
IFNAR1 interferon (alpha, beta and omega) receptor 1
IGF1R insulin-like growth factor 1 receptor
IGFBP1 insulin-like growth factor binding protein 1
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IL1A interleukin 1, alpha
IL2RA interleukin 2 receptor, alpha
INSR insulin receptor
IRF3 interferon regulatory factor 3
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
JAK2 Janus kinase 2
JUNB jun B proto-oncogene
KCNB1 potassium channel, voltage gated Shab related subfamily B, member 1
KCNE2 potassium channel, voltage gated subfamily E regulatory beta subunit 2
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
KLF5 Kruppel-like factor 5 (intestinal)
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
LGALS3 lectin, galactoside-binding, soluble, 3
LIMA1 LIM domain and actin binding 1
LMNA lamin A/C
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MAPT microtubule-associated protein tau
MAZ MYC-associated zinc finger protein (purine-binding transcription factor)
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MDM4 MDM4, p53 regulator
MFN2 mitofusin 2
MIP major intrinsic protein of lens fiber
MITF microphthalmia-associated transcription factor
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MOS v-mos Moloney murine sarcoma viral oncogene homolog
MYB v-myb avian myeloblastosis viral oncogene homolog
MYBPC3 myosin binding protein C, cardiac
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYL12B myosin, light chain 12B, regulatory
MYL9 myosin, light chain 9, regulatory
NCF4 neutrophil cytosolic factor 4, 40kDa
NCOA3 nuclear receptor coactivator 3
NCOR1 nuclear receptor corepressor 1
NCOR2 nuclear receptor corepressor 2
NCSTN nicastrin
NEK11 NIMA-related kinase 11
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
NFE2L1 nuclear factor, erythroid 2-like 1
NFE2L2 nuclear factor, erythroid 2-like 2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
NOTCH1 notch 1
NPHS1 nephrosis 1, congenital, Finnish type (nephrin)
NR4A1 nuclear receptor subfamily 4, group A, member 1
NUCLEOLIN nucleolin multifunctional protein
PAH phenylalanine hydroxylase
PARVA parvin, alpha
PCNA proliferating cell nuclear antigen
PCSK9 proprotein convertase subtilisin/kexin type 9
PHB prohibitin
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1
PJA2 praja ring finger 2, E3 ubiquitin protein ligase
PLN phospholamban
POU5F1 POU class 5 homeobox 1
PPM1B protein phosphatase, Mg2+/Mn2+ dependent, 1B
PPP1R1A protein phosphatase 1, regulatory (inhibitor) subunit 1A
PPP2R5A protein phosphatase 2, regulatory subunit B', alpha
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
PRKCZ protein kinase C, zeta
PRKD1 protein kinase D1
PRKG1 protein kinase, cGMP-dependent, type I
PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7
PTK2 protein tyrosine kinase 2
PTPN5 protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched)
PTPN6 protein tyrosine phosphatase, non-receptor type 6
PTRF polymerase I and transcript release factor
PTTG1 pituitary tumor-transforming 1
PYGM phosphorylase, glycogen, muscle
RAP1GAP RAP1 GTPase activating protein
RARA retinoic acid receptor, alpha
RB1 retinoblastoma 1
RBL2 retinoblastoma-like 2
RBPJ recombination signal binding protein for immunoglobulin kappa J region
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
RUNX2 runt-related transcription factor 2
SATB1 SATB homeobox 1
SETD8 SET domain containing (lysine methyltransferase) 8
SH3PXD2A SH3 and PX domains 2A
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC2A4 solute carrier family 2 (facilitated glucose transporter), member 4
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3
SMC1A structural maintenance of chromosomes 1A
SNX18 sorting nexin 18
SPHK1 sphingosine kinase 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRF serum response factor (c-fos serum response element-binding transcription factor)
SRSF5 serine/arginine-rich splicing factor 5
STAG2 stromal antigen 2
STAR steroidogenic acute regulatory protein
STK4 serine/threonine kinase 4
SYK spleen tyrosine kinase
TAL1 T-cell acute lymphocytic leukemia 1
TBX21 T-box 21
TELO2 telomere maintenance 2
TERF1 telomeric repeat binding factor (NIMA-interacting) 1
TERF2 telomeric repeat binding factor 2
TFAM transcription factor A, mitochondrial
TK1 thymidine kinase 1, soluble
TLN1 talin 1
TNNI3 troponin I type 3 (cardiac)
TOP2A topoisomerase (DNA) II alpha 170kDa
TP53 tumor protein p53
TP63 tumor protein p63
TTI1 TELO2 interacting protein 1
UHRF1 ubiquitin-like with PHD and ring finger domains 1
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
VASP vasodilator-stimulated phosphoprotein
VIM vimentin
WEE1 WEE1 G2 checkpoint kinase
XBP1 X-box binding protein 1
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
ZFHX3 zinc finger homeobox 3