proteolytic Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
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Genes

420 genes co-occuring with the biological term proteolytic in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
A2M alpha-2-macroglobulin
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ADAM10 ADAM metallopeptidase domain 10
ADAM17 ADAM metallopeptidase domain 17
ADAM19 ADAM metallopeptidase domain 19
ADAM8 ADAM metallopeptidase domain 8
ADAM9 ADAM metallopeptidase domain 9
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13
ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif, 4
ADGRB2 adhesion G protein-coupled receptor B2
AGER advanced glycosylation end product-specific receptor
AKIP1 A kinase (PRKA) interacting protein 1
AKT1 v-akt murine thymoma viral oncogene homolog 1
ANGPTL4 angiopoietin-like 4
APAF1 apoptotic peptidase activating factor 1
APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
APH1A APH1A gamma secretase subunit
APLP2 amyloid beta (A4) precursor-like protein 2
APOA1 apolipoprotein A-I
APOE apolipoprotein E
APP amyloid beta (A4) precursor protein
ATP7A ATPase, Cu++ transporting, alpha polypeptide
ATXN3 ataxin 3
ATXN7 ataxin 7
AURKA aurora kinase A
AVPR2 arginine vasopressin receptor 2
BACE1 beta-site APP-cleaving enzyme 1
BACE2 beta-site APP-cleaving enzyme 2
BAK1 BCL2-antagonist/killer 1
BAX BCL2-associated X protein
BCAN brevican
BCL2 B-cell CLL/lymphoma 2
BDNF brain-derived neurotrophic factor
BID BH3 interacting domain death agonist
BIRC3 baculoviral IAP repeat containing 3
BMP1 bone morphogenetic protein 1
BMP2 bone morphogenetic protein 2
BRCA1 breast cancer 1, early onset
BSG basigin (Ok blood group)
C3 complement component 3
C9ORF3 chromosome 9 open reading frame 3
CAMP cathelicidin antimicrobial peptide
CAPN1 calpain 1, (mu/I) large subunit
CAPN10 calpain 10
CAPN2 calpain 2, (m/II) large subunit
CAPN3 calpain 3, (p94)
CAPN7 calpain 7
CASP1 caspase 1, apoptosis-related cysteine peptidase
CASP12 caspase 12 (gene/pseudogene)
CASP14 caspase 14, apoptosis-related cysteine peptidase
CASP2 caspase 2, apoptosis-related cysteine peptidase
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP7 caspase 7, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CASP9 caspase 9, apoptosis-related cysteine peptidase
CCL14 chemokine (C-C motif) ligand 14
CCL2 chemokine (C-C motif) ligand 2
CCNE1 cyclin E1
CD109 CD109 molecule
CD34 CD34 molecule
CD44 CD44 molecule (Indian blood group)
CD82 CD82 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDH3 cadherin 3, type 1, P-cadherin (placental)
CDH5 cadherin 5, type 2 (vascular endothelium)
CDKN2A cyclin-dependent kinase inhibitor 2A
CFD complement factor D (adipsin)
CFI complement factor I
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CHGA chromogranin A
CHM choroideremia (Rab escort protein 1)
CLPP caseinolytic mitochondrial matrix peptidase proteolytic subunit
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit
CMA1 chymase 1, mast cell
CMKLR1 chemerin chemokine-like receptor 1
COL6A2 collagen, type VI, alpha 2
CR1 complement component (3b/4b) receptor 1 (Knops blood group)
CSF1R colony stimulating factor 1 receptor
CSK c-src tyrosine kinase
CSNK2A1 casein kinase 2, alpha 1 polypeptide
CST1 cystatin SN
CSTA cystatin A (stefin A)
CSTB cystatin B (stefin B)
CTF1 cardiotrophin 1
CTSB cathepsin B
CTSD cathepsin D
CTSG cathepsin G
CTSK cathepsin K
CTSL cathepsin L
CTSS cathepsin S
CUL4A cullin 4A
CUX1 cut-like homeobox 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL12 chemokine (C-X-C motif) ligand 12
CXCR4 chemokine (C-X-C motif) receptor 4
DAPK1 death-associated protein kinase 1
DCD dermcidin
DDB2 damage-specific DNA binding protein 2, 48kDa
DIRC2 disrupted in renal carcinoma 2
DLD dihydrolipoamide dehydrogenase
DMPK dystrophia myotonica-protein kinase
DSG2 desmoglein 2
DSG3 desmoglein 3
ECM1 extracellular matrix protein 1
EEF2 eukaryotic translation elongation factor 2
EGF epidermal growth factor
EGFR epidermal growth factor receptor
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2
ELANE elastase, neutrophil expressed
EPCAM epithelial cell adhesion molecule
EPOR erythropoietin receptor
ERAP1 endoplasmic reticulum aminopeptidase 1
ERBB4 erb-b2 receptor tyrosine kinase 4
ERN1 endoplasmic reticulum to nucleus signaling 1
ESX1 ESX homeobox 1
F11 coagulation factor XI
F12 coagulation factor XII (Hageman factor)
F2 coagulation factor II (thrombin)
F2R coagulation factor II (thrombin) receptor
F3 coagulation factor III (thromboplastin, tissue factor)
F5 coagulation factor V (proaccelerin, labile factor)
F7 coagulation factor VII (serum prothrombin conversion accelerator)
F8 coagulation factor VIII, procoagulant component
FANCC Fanconi anemia, complementation group C
FAP fibroblast activation protein, alpha
FBXL5 F-box and leucine-rich repeat protein 5
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FCN3 ficolin (collagen/fibrinogen domain containing) 3
FGF1 fibroblast growth factor 1 (acidic)
FGF23 fibroblast growth factor 23
FGFR1 fibroblast growth factor receptor 1
FLG2 filaggrin family member 2
FLT4 fms-related tyrosine kinase 4
FN1 fibronectin 1
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
FOXO3 forkhead box O3
FSHR follicle stimulating hormone receptor
FURIN furin (paired basic amino acid cleaving enzyme)
FXN frataxin
GAA glucosidase, alpha; acid
GALE UDP-galactose-4-epimerase
GGA1 golgi-associated, gamma adaptin ear containing, ARF binding protein 1
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)
GNRH2 gonadotropin-releasing hormone 2
GP6 glycoprotein VI (platelet)
GPNMB glycoprotein (transmembrane) nmb
GPX1 glutathione peroxidase 1
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B
GRN granulin
GSK3B glycogen synthase kinase 3 beta
GSN gelsolin
GSPT1 G1 to S phase transition 1
GSPT2 G1 to S phase transition 2
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
GZMH granzyme H (cathepsin G-like 2, protein h-CCPX)
GZMM granzyme M (lymphocyte met-ase 1)
H2AFJ H2A histone family, member J
H2AFX H2A histone family, member X
HABP2 hyaluronan binding protein 2
HAMP hepcidin antimicrobial peptide
HAVCR2 hepatitis A virus cellular receptor 2
HCFC1 host cell factor C1
HGSNAT heparan-alpha-glucosaminide N-acetyltransferase
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HLA-G major histocompatibility complex, class I, G
HMOX1 heme oxygenase 1
HP haptoglobin
HPN hepsin
HPSE heparanase
HRG histidine-rich glycoprotein
HRNR hornerin
HSPB1 heat shock 27kDa protein 1
HTRA1 HtrA serine peptidase 1
HTRA2 HtrA serine peptidase 2
HTT huntingtin
IFNAR1 interferon (alpha, beta and omega) receptor 1
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF2 insulin-like growth factor 2
IGFBP1 insulin-like growth factor binding protein 1
IGFBP3 insulin-like growth factor binding protein 3
IGFBP4 insulin-like growth factor binding protein 4
IGFBP5 insulin-like growth factor binding protein 5
IGFBP7 insulin-like growth factor binding protein 7
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IL15 interleukin 15
IL15RA interleukin 15 receptor, alpha
IL17A interleukin 17A
IL1A interleukin 1, alpha
IL1R2 interleukin 1 receptor, type II
IL6R interleukin 6 receptor
INHA inhibin, alpha
INHBB inhibin, beta B
INS insulin
INSIG1 insulin induced gene 1
IRF3 interferon regulatory factor 3
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITGB4 integrin, beta 4
ITM2B integral membrane protein 2B
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KDR kinase insert domain receptor
KITLG KIT ligand
KLK14 kallikrein-related peptidase 14
KLK3 kallikrein-related peptidase 3
KLK5 kallikrein-related peptidase 5
KLK7 kallikrein-related peptidase 7
L1CAM L1 cell adhesion molecule
LACRT lacritin
LAMA3 laminin, alpha 3
LAMB3 laminin, beta 3
LAMC2 laminin, gamma 2
LDLR low density lipoprotein receptor
LECT1 leukocyte cell derived chemotaxin 1
LGALS3 lectin, galactoside-binding, soluble, 3
LGALS9 lectin, galactoside-binding, soluble, 9
LGMN legumain
LONP2 lon peptidase 2, peroxisomal
LRP1 low density lipoprotein receptor-related protein 1
LRP1B low density lipoprotein receptor-related protein 1B
LRP6 low density lipoprotein receptor-related protein 6
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
LTBP1 latent transforming growth factor beta binding protein 1
MALT1 MALT1 paracaspase
MAP3K11 mitogen-activated protein kinase kinase kinase 11
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MAPT microtubule-associated protein tau
MASP1 mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)
MBL2 mannose-binding lectin (protein C) 2, soluble
MBP myelin basic protein
MBTPS1 membrane-bound transcription factor peptidase, site 1
MCOLN1 mucolipin 1
MDM4 MDM4, p53 regulator
MEP1B meprin A, beta
MET MET proto-oncogene, receptor tyrosine kinase
MICA MHC class I polypeptide-related sequence A
MME membrane metallo-endopeptidase
MMP1 matrix metallopeptidase 1
MMP12 matrix metallopeptidase 12
MMP13 matrix metallopeptidase 13
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MMP19 matrix metallopeptidase 19
MMP2 matrix metallopeptidase 2
MMP25 matrix metallopeptidase 25
MMP3 matrix metallopeptidase 3
MMP7 matrix metallopeptidase 7
MMP8 matrix metallopeptidase 8
MMP9 matrix metallopeptidase 9
MPL MPL proto-oncogene, thrombopoietin receptor
MUC1 mucin 1, cell surface associated
MUC4 mucin 4, cell surface associated
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
MYOC myocilin, trabecular meshwork inducible glucocorticoid response
NCAM1 neural cell adhesion molecule 1
NCSTN nicastrin
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
NFE2L1 nuclear factor, erythroid 2-like 1
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NOS1 nitric oxide synthase 1 (neuronal)
NOS3 nitric oxide synthase 3 (endothelial cell)
NOTCH2 notch 2
NPPB natriuretic peptide B
NQO2 NAD(P)H dehydrogenase, quinone 2
NUCB2 nucleobindin 2
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
OMA1 OMA1 zinc metallopeptidase
OPA1 optic atrophy 1 (autosomal dominant)
PAPPA pregnancy-associated plasma protein A, pappalysin 1
PARL presenilin associated, rhomboid-like
PCDH12 protocadherin 12
PCNA proliferating cell nuclear antigen
PCOLCE2 procollagen C-endopeptidase enhancer 2
PCSK1 proprotein convertase subtilisin/kexin type 1
PCSK5 proprotein convertase subtilisin/kexin type 5
PDGFA platelet-derived growth factor alpha polypeptide
PDGFB platelet-derived growth factor beta polypeptide
PDGFD platelet derived growth factor D
PDZD2 PDZ domain containing 2
PENK proenkephalin
PF4 platelet factor 4
PGC progastricsin (pepsinogen C)
PI3 peptidase inhibitor 3, skin-derived
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PITRM1 pitrilysin metallopeptidase 1
PKD1 polycystic kidney disease 1 (autosomal dominant)
PKHD1 polycystic kidney and hepatic disease 1 (autosomal recessive)
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PLAUR plasminogen activator, urokinase receptor
PLG plasminogen
PLTP phospholipid transfer protein
PMEL premelanosome protein
POU2F3 POU class 2 homeobox 3
POU3F1 POU class 3 homeobox 1
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PPP3R2 protein phosphatase 3, regulatory subunit B, beta
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PRKCD protein kinase C, delta
PRKCZ protein kinase C, zeta
PRKD2 protein kinase D2
PRNP prion protein
PROS1 protein S (alpha)
PRSS2 protease, serine, 2 (trypsin 2)
PRSS3 protease, serine, 3
PRSS8 protease, serine, 8
PSAP prosaposin
PSEN1 presenilin 1
PSEN2 presenilin 2
PSENEN presenilin enhancer gamma secretase subunit
PSMA5 proteasome (prosome, macropain) subunit, alpha type, 5
PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1
PTAFR platelet-activating factor receptor
PTBP1 polypyrimidine tract binding protein 1
PTEN phosphatase and tensin homolog
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTK2 protein tyrosine kinase 2
PTK6 protein tyrosine kinase 6
PTPN1 protein tyrosine phosphatase, non-receptor type 1
PTPRA protein tyrosine phosphatase, receptor type, A
PTPRF protein tyrosine phosphatase, receptor type, F
PTRF polymerase I and transcript release factor
RAB5A RAB5A, member RAS oncogene family
RAD23B RAD23 homolog B (S. cerevisiae)
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RBMX RNA binding motif protein, X-linked
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RELN reelin
RHBDL2 rhomboid, veinlet-like 2 (Drosophila)
RHO rhodopsin
RHOA ras homolog family member A
RPA1 replication protein A1, 70kDa
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SCNN1D sodium channel, non voltage gated 1 delta subunit
SCNN1G sodium channel, non voltage gated 1 gamma subunit
SCUBE3 signal peptide, CUB domain, EGF-like 3
SDC1 syndecan 1
SELPLG selectin P ligand
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINF2 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
SFTPB surfactant protein B
SIAH1 siah E3 ubiquitin protein ligase 1
SLC26A3 solute carrier family 26 (anion exchanger), member 3
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group)
SLPI secretory leukocyte peptidase inhibitor
SMAD2 SMAD family member 2
SMAD3 SMAD family member 3
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SOD1 superoxide dismutase 1, soluble
SOD3 superoxide dismutase 3, extracellular
SOX9 SRY (sex determining region Y)-box 9
SP1 Sp1 transcription factor
SPINK5 serine peptidase inhibitor, Kazal type 5
SPINK9 serine peptidase inhibitor, Kazal type 9
SPINT1 serine peptidase inhibitor, Kunitz type 1
SPP1 secreted phosphoprotein 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SREBF1 sterol regulatory element binding transcription factor 1
SREBF2 sterol regulatory element binding transcription factor 2
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)
ST14 suppression of tumorigenicity 14 (colon carcinoma)
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
STARD3 StAR-related lipid transfer (START) domain containing 3
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STK24 serine/threonine kinase 24
STK39 serine threonine kinase 39
STOM stomatin
STX2 syntaxin 2
TDP2 tyrosyl-DNA phosphodiesterase 2
TEK TEK tyrosine kinase, endothelial
TF transferrin
TGFB1 transforming growth factor, beta 1
TGFBI transforming growth factor, beta-induced, 68kDa
THBS1 thrombospondin 1
TICAM1 toll-like receptor adaptor molecule 1
TIMP2 TIMP metallopeptidase inhibitor 2
TIMP3 TIMP metallopeptidase inhibitor 3
TK1 thymidine kinase 1, soluble
TLR3 toll-like receptor 3
TLR5 toll-like receptor 5
TLR9 toll-like receptor 9
TMPRSS11D transmembrane protease, serine 11D
TMPRSS13 transmembrane protease, serine 13
TMPRSS2 transmembrane protease, serine 2
TMPRSS3 transmembrane protease, serine 3
TMPRSS4 transmembrane protease, serine 4
TMPRSS6 transmembrane protease, serine 6
TNF tumor necrosis factor
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNS2 tensin 2
TOP2A topoisomerase (DNA) II alpha 170kDa
TOP2B topoisomerase (DNA) II beta 180kDa
TP53 tumor protein p53
TP53I3 tumor protein p53 inducible protein 3
TPP1 tripeptidyl peptidase I
TPSAB1 tryptase alpha/beta 1
TREM1 triggering receptor expressed on myeloid cells 1
TYSND1 trypsin domain containing 1
UBE3A ubiquitin protein ligase E3A
UCP3 uncoupling protein 3 (mitochondrial, proton carrier)
UMOD uromodulin
USP11 ubiquitin specific peptidase 11
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
USP8 ubiquitin specific peptidase 8
VEGFA vascular endothelial growth factor A
VLDLR very low density lipoprotein receptor
VTN vitronectin
VWF von Willebrand factor
WFDC2 WAP four-disulfide core domain 2
XPC xeroderma pigmentosum, complementation group C
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6
YME1L1 YME1-like 1 ATPase
ZMPSTE24 zinc metallopeptidase STE24
ZNF395 zinc finger protein 395