| Dataset | CMAP Signatures of Differentially Expressed Genes for Small Molecules |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis) |
| Similar Terms | |
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199 genes differentially expressed following the protriptyline-3119 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
| Symbol | Name |
|---|---|
| ABHD6 | abhydrolase domain containing 6 |
| AFF4 | AF4/FMR2 family, member 4 |
| AKAP8L | A kinase (PRKA) anchor protein 8-like |
| AKT2 | v-akt murine thymoma viral oncogene homolog 2 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 |
| ARVCF | armadillo repeat gene deleted in velocardiofacial syndrome |
| ATF6B | activating transcription factor 6 beta |
| ATP9A | ATPase, class II, type 9A |
| ATXN8OS | ATXN8 opposite strand (non-protein coding) |
| AURKA | aurora kinase A |
| BCAS1 | breast carcinoma amplified sequence 1 |
| BTN2A2 | butyrophilin, subfamily 2, member A2 |
| C4ORF19 | chromosome 4 open reading frame 19 |
| CDH1 | cadherin 1, type 1, E-cadherin (epithelial) |
| CDON | cell adhesion associated, oncogene regulated |
| CLTA | clathrin, light chain A |
| COL9A3 | collagen, type IX, alpha 3 |
| CTSE | cathepsin E |
| DNAJC16 | DnaJ (Hsp40) homolog, subfamily C, member 16 |
| DOCK6 | dedicator of cytokinesis 6 |
| DPYSL3 | dihydropyrimidinase-like 3 |
| DRD2 | dopamine receptor D2 |
| EFNB2 | ephrin-B2 |
| EFR3B | EFR3 homolog B (S. cerevisiae) |
| EIF1 | eukaryotic translation initiation factor 1 |
| ENOX1 | ecto-NOX disulfide-thiol exchanger 1 |
| ESR1 | estrogen receptor 1 |
| F2R | coagulation factor II (thrombin) receptor |
| FAM120C | family with sequence similarity 120C |
| FAM127B | family with sequence similarity 127, member B |
| FRAS1 | Fraser extracellular matrix complex subunit 1 |
| GABRR2 | gamma-aminobutyric acid (GABA) A receptor, rho 2 |
| GLYAT | glycine-N-acyltransferase |
| GZMB | granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) |
| HAP1 | huntingtin-associated protein 1 |
| HBB | hemoglobin, beta |
| HLA-DOA | major histocompatibility complex, class II, DO alpha |
| HLCS | holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase) |
| HMOX1 | heme oxygenase 1 |
| HYAL1 | hyaluronoglucosaminidase 1 |
| IFT27 | intraflagellar transport 27 |
| IGFBP5 | insulin-like growth factor binding protein 5 |
| IGHG1 | immunoglobulin heavy constant gamma 1 (G1m marker) |
| INF2 | inverted formin, FH2 and WH2 domain containing |
| KLHL25 | kelch-like family member 25 |
| LDLR | low density lipoprotein receptor |
| LOC257152 | uncharacterized LOC257152 |
| LPAL2 | lipoprotein, Lp(a)-like 2, pseudogene |
| MAOA | monoamine oxidase A |
| MAPK11 | mitogen-activated protein kinase 11 |
| MAST2 | microtubule associated serine/threonine kinase 2 |
| MMP24 | matrix metallopeptidase 24 (membrane-inserted) |
| MOBP | myelin-associated oligodendrocyte basic protein |
| MORN1 | MORN repeat containing 1 |
| MTCL1 | microtubule crosslinking factor 1 |
| MTRF1L | mitochondrial translational release factor 1-like |
| NBL1 | neuroblastoma 1, DAN family BMP antagonist |
| NR2F2 | nuclear receptor subfamily 2, group F, member 2 |
| NTRK2 | neurotrophic tyrosine kinase, receptor, type 2 |
| PAX2 | paired box 2 |
| PCDHA9 | protocadherin alpha 9 |
| PDGFB | platelet-derived growth factor beta polypeptide |
| PDK4 | pyruvate dehydrogenase kinase, isozyme 4 |
| PEG10 | paternally expressed 10 |
| PEX6 | peroxisomal biogenesis factor 6 |
| PLA2G2A | phospholipase A2, group IIA (platelets, synovial fluid) |
| PLEKHF1 | pleckstrin homology domain containing, family F (with FYVE domain) member 1 |
| POU6F1 | POU class 6 homeobox 1 |
| PRPH | peripherin |
| PTCRA | pre T-cell antigen receptor alpha |
| RARRES2 | retinoic acid receptor responder (tazarotene induced) 2 |
| RASGRP3 | RAS guanyl releasing protein 3 (calcium and DAG-regulated) |
| RCN3 | reticulocalbin 3, EF-hand calcium binding domain |
| RETN | resistin |
| RGS14 | regulator of G-protein signaling 14 |
| RRBP1 | ribosome binding protein 1 |
| RUNX1T1 | runt-related transcription factor 1; translocated to, 1 (cyclin D-related) |
| RYR2 | ryanodine receptor 2 (cardiac) |
| SCIN | scinderin |
| SCN11A | sodium channel, voltage gated, type XI alpha subunit |
| SCUBE3 | signal peptide, CUB domain, EGF-like 3 |
| SLC28A3 | solute carrier family 28 (concentrative nucleoside transporter), member 3 |
| SLCO4C1 | solute carrier organic anion transporter family, member 4C1 |
| SNAI1 | snail family zinc finger 1 |
| SOX13 | SRY (sex determining region Y)-box 13 |
| SPOCK3 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3 |
| SRR | serine racemase |
| STMN4 | stathmin-like 4 |
| SYT13 | synaptotagmin XIII |
| TAS2R9 | taste receptor, type 2, member 9 |
| TBX2 | T-box 2 |
| TEAD3 | TEA domain family member 3 |
| TEX40 | testis expressed 40 |
| TICAM1 | toll-like receptor adaptor molecule 1 |
| TM4SF4 | transmembrane 4 L six family member 4 |
| WASF3 | WAS protein family, member 3 |
| WDR4 | WD repeat domain 4 |
| YPEL1 | yippee-like 1 (Drosophila) |
| ZC3H7B | zinc finger CCCH-type containing 7B |
| ZNF696 | zinc finger protein 696 |
| Symbol | Name |
|---|---|
| AGPAT3 | 1-acylglycerol-3-phosphate O-acyltransferase 3 |
| ALPK1 | alpha-kinase 1 |
| ARAP3 | ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 |
| ARL15 | ADP-ribosylation factor-like 15 |
| ARL2 | ADP-ribosylation factor-like 2 |
| ARRB1 | arrestin, beta 1 |
| ASPSCR1 | alveolar soft part sarcoma chromosome region, candidate 1 |
| ATAD3A | ATPase family, AAA domain containing 3A |
| ATP8B2 | ATPase, aminophospholipid transporter, class I, type 8B, member 2 |
| BATF | basic leucine zipper transcription factor, ATF-like |
| BTBD18 | BTB (POZ) domain containing 18 |
| C14ORF93 | chromosome 14 open reading frame 93 |
| C7ORF43 | chromosome 7 open reading frame 43 |
| C8ORF60 | chromosome 8 open reading frame 60 |
| CCNJ | cyclin J |
| CD69 | CD69 molecule |
| COL15A1 | collagen, type XV, alpha 1 |
| CORT | cortistatin |
| CTDP1 | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1 |
| CXORF56 | chromosome X open reading frame 56 |
| CYP27B1 | cytochrome P450, family 27, subfamily B, polypeptide 1 |
| CYSLTR1 | cysteinyl leukotriene receptor 1 |
| DDX31 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 31 |
| DEPDC1 | DEP domain containing 1 |
| ERCC2 | excision repair cross-complementation group 2 |
| FAM204A | family with sequence similarity 204, member A |
| FOXN2 | forkhead box N2 |
| GABPA | GA binding protein transcription factor, alpha subunit 60kDa |
| GLTSCR1 | glioma tumor suppressor candidate region gene 1 |
| GSTA4 | glutathione S-transferase alpha 4 |
| HERC3 | HECT and RLD domain containing E3 ubiquitin protein ligase 3 |
| HIST1H1E | histone cluster 1, H1e |
| HIST1H2BC | histone cluster 1, H2bc |
| IGLV1-44 | immunoglobulin lambda variable 1-44 |
| IL12B | interleukin 12B |
| IPO4 | importin 4 |
| IRF7 | interferon regulatory factor 7 |
| JADE3 | jade family PHD finger 3 |
| JUNB | jun B proto-oncogene |
| KPTN | kaptin (actin binding protein) |
| LIMD2 | LIM domain containing 2 |
| LPAR6 | lysophosphatidic acid receptor 6 |
| LRRK1 | leucine-rich repeat kinase 1 |
| LY6E | lymphocyte antigen 6 complex, locus E |
| MAFB | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B |
| MAP3K1 | mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase |
| MDM4 | MDM4, p53 regulator |
| MED22 | mediator complex subunit 22 |
| METTL2B | methyltransferase like 2B |
| METTL8 | methyltransferase like 8 |
| MLYCD | malonyl-CoA decarboxylase |
| MMACHC | methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria |
| MMP9 | matrix metallopeptidase 9 |
| MTCP1 | mature T-cell proliferation 1 |
| MTG1 | mitochondrial ribosome-associated GTPase 1 |
| MTHFS | 5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase) |
| MXD3 | MAX dimerization protein 3 |
| MYBPH | myosin binding protein H |
| N6AMT1 | N-6 adenine-specific DNA methyltransferase 1 (putative) |
| NABP1 | nucleic acid binding protein 1 |
| NAGPA | N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase |
| NFKBIL1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1 |
| NOL6 | nucleolar protein 6 (RNA-associated) |
| NR1H3 | nuclear receptor subfamily 1, group H, member 3 |
| PAQR4 | progestin and adipoQ receptor family member IV |
| PHC1 | polyhomeotic homolog 1 (Drosophila) |
| PIAS3 | protein inhibitor of activated STAT, 3 |
| PILRB | paired immunoglobin-like type 2 receptor beta |
| PLCD1 | phospholipase C, delta 1 |
| PMCH | pro-melanin-concentrating hormone |
| PPIP5K1 | diphosphoinositol pentakisphosphate kinase 1 |
| PPOX | protoporphyrinogen oxidase |
| PRDM1 | PR domain containing 1, with ZNF domain |
| PRG2 | proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) |
| RPS6KA4 | ribosomal protein S6 kinase, 90kDa, polypeptide 4 |
| RRP1 | ribosomal RNA processing 1 |
| S100A12 | S100 calcium binding protein A12 |
| S100A9 | S100 calcium binding protein A9 |
| SALL2 | spalt-like transcription factor 2 |
| SCAI | suppressor of cancer cell invasion |
| SIRT6 | sirtuin 6 |
| SLC29A3 | solute carrier family 29 (equilibrative nucleoside transporter), member 3 |
| SLC35F6 | solute carrier family 35, member F6 |
| SOGA1 | suppressor of glucose, autophagy associated 1 |
| SPR | sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase) |
| SPTLC3 | serine palmitoyltransferase, long chain base subunit 3 |
| TASP1 | taspase, threonine aspartase, 1 |
| TCEA2 | transcription elongation factor A (SII), 2 |
| TGM5 | transglutaminase 5 |
| TRDMT1 | tRNA aspartic acid methyltransferase 1 |
| TUT1 | terminal uridylyl transferase 1, U6 snRNA-specific |
| WDR3 | WD repeat domain 3 |
| WDR46 | WD repeat domain 46 |
| YOD1 | YOD1 deubiquitinase |
| ZC3H12A | zinc finger CCCH-type containing 12A |
| ZHX2 | zinc fingers and homeoboxes 2 |
| ZNF480 | zinc finger protein 480 |
| ZNF593 | zinc finger protein 593 |
| ZNF93 | zinc finger protein 93 |
