proximal convoluted tubule brush border loss Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description attenuation or degeneration of the microvillus brush border normally present on the luminal surface of epithelial cells of the proximal convoluted tubule; may be associated with renal tubular injury and/or cystic changes (Mammalian Phenotype Ontology, MP_0011352)
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10 gene mutations causing the proximal convoluted tubule brush border loss phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
AQP11 aquaporin 11
HMOX1 heme oxygenase 1
INVS inversin
MEP1A meprin A, alpha (PABA peptide hydrolase)
MEP1B meprin A, beta
MYO1E myosin IE
PKHD1 polycystic kidney and hepatic disease 1 (autosomal recessive)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
REN renin
RRM2B ribonucleotide reductase M2 B (TP53 inducible)