proxymetacaine-3113 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

200 genes differentially expressed following the proxymetacaine-3113 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABI2 abl-interactor 2
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2
ACOX2 acyl-CoA oxidase 2, branched chain
AGFG2 ArfGAP with FG repeats 2
ARHGDIG Rho GDP dissociation inhibitor (GDI) gamma
ATP2A3 ATPase, Ca++ transporting, ubiquitous
ATXN2L ataxin 2-like
BAIAP2 BAI1-associated protein 2
BMP7 bone morphogenetic protein 7
CD226 CD226 molecule
CD320 CD320 molecule
CDON cell adhesion associated, oncogene regulated
CES3 carboxylesterase 3
CLTC clathrin, heavy chain (Hc)
CNTNAP1 contactin associated protein 1
COBLL1 cordon-bleu WH2 repeat protein-like 1
COL1A2 collagen, type I, alpha 2
CRABP2 cellular retinoic acid binding protein 2
CST4 cystatin S
CUL3 cullin 3
CYFIP2 cytoplasmic FMR1 interacting protein 2
DCHS2 dachsous cadherin-related 2
DST dystonin
EFNA5 ephrin-A5
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
ELK4 ELK4, ETS-domain protein (SRF accessory protein 1)
ENG endoglin
FAM215A family with sequence similarity 215, member A (non-protein coding)
FBXL7 F-box and leucine-rich repeat protein 7
FGD1 FYVE, RhoGEF and PH domain containing 1
FGL1 fibrinogen-like 1
FOXG1 forkhead box G1
FRMPD4 FERM and PDZ domain containing 4
GAP43 growth associated protein 43
GATA3 GATA binding protein 3
GFOD2 glucose-fructose oxidoreductase domain containing 2
GJA8 gap junction protein, alpha 8, 50kDa
GRIK5 glutamate receptor, ionotropic, kainate 5
GRM8 glutamate receptor, metabotropic 8
HFE hemochromatosis
HOXB5 homeobox B5
HSPG2 heparan sulfate proteoglycan 2
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
IBSP integrin-binding sialoprotein
IDUA iduronidase, alpha-L-
IFNA14 interferon, alpha 14
IL17RC interleukin 17 receptor C
IL1A interleukin 1, alpha
IL36G interleukin 36, gamma
KCNE1 potassium channel, voltage gated subfamily E regulatory beta subunit 1
KCNE5 potassium channel, voltage gated subfamily E regulatory beta subunit 5
LECT1 leukocyte cell derived chemotaxin 1
LEF1 lymphoid enhancer-binding factor 1
MAP4 microtubule-associated protein 4
MED27 mediator complex subunit 27
MFAP3L microfibrillar-associated protein 3-like
MID1 midline 1
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
MPP2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)
MSRB2 methionine sulfoxide reductase B2
MX1 MX dynamin-like GTPase 1
MYL4 myosin, light chain 4, alkali; atrial, embryonic
MYO15A myosin XVA
NBL1 neuroblastoma 1, DAN family BMP antagonist
NEBL nebulette
NOTCH3 notch 3
NOVA2 neuro-oncological ventral antigen 2
NTSR1 neurotensin receptor 1 (high affinity)
OPTN optineurin
PDCD6 programmed cell death 6
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PEG3 paternally expressed 3
PLCG1 phospholipase C, gamma 1
PLXNC1 plexin C1
PPL periplakin
PPP2R5B protein phosphatase 2, regulatory subunit B', beta
PRKCA protein kinase C, alpha
PTGIS prostaglandin I2 (prostacyclin) synthase
RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1
RECQL5 RecQ protein-like 5
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
RYR1 ryanodine receptor 1 (skeletal)
SERHL2 serine hydrolase-like 2
SFI1 Sfi1 homolog, spindle assembly associated (yeast)
SLC12A7 solute carrier family 12 (potassium/chloride transporter), member 7
SLC17A2 solute carrier family 17, member 2
SLC30A3 solute carrier family 30 (zinc transporter), member 3
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2
SLIT1 slit homolog 1 (Drosophila)
SPDEF SAM pointed domain containing ETS transcription factor
SRCAP Snf2-related CREBBP activator protein
SYN2 synapsin II
TDRD1 tudor domain containing 1
TEF thyrotrophic embryonic factor
TGFB1 transforming growth factor, beta 1
TNFAIP1 tumor necrosis factor, alpha-induced protein 1 (endothelial)
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TUBG2 tubulin, gamma 2
ZNF771 zinc finger protein 771

decreased expression

Symbol Name
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ACO1 aconitase 1, soluble
AP1B1 adaptor-related protein complex 1, beta 1 subunit
ATAD3A ATPase family, AAA domain containing 3A
ATG16L1 autophagy related 16-like 1 (S. cerevisiae)
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
B3GNT1
BTBD18 BTB (POZ) domain containing 18
BZRAP1 benzodiazepine receptor (peripheral) associated protein 1
C14ORF159 chromosome 14 open reading frame 159
C7ORF43 chromosome 7 open reading frame 43
CA5BP1 carbonic anhydrase VB pseudogene 1
CCZ1B CCZ1 vacuolar protein trafficking and biogenesis associated homolog B (S. cerevisiae)
CD38 CD38 molecule
CEL carboxyl ester lipase
CGREF1 cell growth regulator with EF-hand domain 1
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHMP7 charged multivesicular body protein 7
CLCN5 chloride channel, voltage-sensitive 5
CNTN1 contactin 1
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CXCL2 chemokine (C-X-C motif) ligand 2
DCAF17 DDB1 and CUL4 associated factor 17
DEAF1 DEAF1 transcription factor
DECR2 2,4-dienoyl CoA reductase 2, peroxisomal
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
ECSIT ECSIT signalling integrator
EPHA4 EPH receptor A4
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ERCC2 excision repair cross-complementation group 2
FGF9 fibroblast growth factor 9
GSTZ1 glutathione S-transferase zeta 1
HIST1H1T histone cluster 1, H1t
HPS6 Hermansky-Pudlak syndrome 6
IDI2-AS1 IDI2 antisense RNA 1
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
IQSEC2 IQ motif and Sec7 domain 2
KANSL1L KAT8 regulatory NSL complex subunit 1-like
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KLRG1 killer cell lectin-like receptor subfamily G, member 1
LINC00260 long intergenic non-protein coding RNA 260
LNPEP leucyl/cystinyl aminopeptidase
LOC100286895 cell division cycle 27 homolog pseudogene
MAGOHB mago-nashi homolog B (Drosophila)
MATK megakaryocyte-associated tyrosine kinase
MED15 mediator complex subunit 15
MED22 mediator complex subunit 22
MGAT4A mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3
MKL2 MKL/myocardin-like 2
MYL5 myosin, light chain 5, regulatory
MYO9A myosin IXA
N4BP2L2-IT2 N4BPL2 intronic transcript 2
NCS1 neuronal calcium sensor 1
NHEJ1 nonhomologous end-joining factor 1
NINJ2 ninjurin 2
NOL10 nucleolar protein 10
NSUN6 NOP2/Sun domain family, member 6
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PELP1 proline, glutamate and leucine rich protein 1
PHC1 polyhomeotic homolog 1 (Drosophila)
PIR pirin (iron-binding nuclear protein)
POMGNT1 protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-)
PYGB phosphorylase, glycogen; brain
RAD9A RAD9 homolog A (S. pombe)
RFPL1S RFPL1 antisense RNA 1
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1
RRP9 ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast)
SATB1 SATB homeobox 1
SCML2 sex comb on midleg-like 2 (Drosophila)
SCN10A sodium channel, voltage gated, type X alpha subunit
SFT2D2 SFT2 domain containing 2
SGPP1 sphingosine-1-phosphate phosphatase 1
SIGLEC15 sialic acid binding Ig-like lectin 15
SIL1 SIL1 nucleotide exchange factor
SLC22A18AS solute carrier family 22 (organic cation transporter), member 18 antisense
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SMR3A submaxillary gland androgen regulated protein 3A
SNHG20 small nucleolar RNA host gene 20
SPATA20 spermatogenesis associated 20
SPIDR scaffolding protein involved in DNA repair
SPRYD7 SPRY domain containing 7
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TMEM254 transmembrane protein 254
TMEM8A transmembrane protein 8A
TRABD TraB domain containing
TRAF2 TNF receptor-associated factor 2
TRMU tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific
UNC13B unc-13 homolog B (C. elegans)
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae)
VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae)
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial
ZFHX3 zinc finger homeobox 3
ZNF177 zinc finger protein 177
ZNF286A zinc finger protein 286A