pruritus Gene Set

Dataset HPO Gene-Disease Associations
Category disease or phenotype associations
Type phenotype
Description Pruritus is an itch or a sensation that makes a person want to scratch. This term refers to an abnormally increased disposition to experience pruritus. (Human Phenotype Ontology, HP_0000989)
External Link http://compbio.charite.de/hpoweb/showterm?id=HP:0000989
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Genes

70 genes associated with the pruritus phenotype by mapping known disease genes to disease phenotypes from the HPO Gene-Disease Associations dataset.

Symbol Name
ABCA12 ATP-binding cassette, sub-family A (ABC1), member 12
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11
ABCB4 ATP-binding cassette, sub-family B (MDR/TAP), member 4
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6
ADA adenosine deaminase
ALOX12B arachidonate 12-lipoxygenase, 12R type
ALOXE3 arachidonate lipoxygenase 3
APCDD1 adenomatosis polyposis coli down-regulated 1
AQP5 aquaporin 5
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1
BAAT bile acid CoA:amino acid N-acyltransferase
CARD14 caspase recruitment domain family, member 14
CARD9 caspase recruitment domain family, member 9
CDSN corneodesmosin
CERS3 ceramide synthase 3
CHD7 chromodomain helicase DNA binding protein 7
CLEC7A C-type lectin domain family 7, member A
COL7A1 collagen, type VII, alpha 1
CYP4F22 cytochrome P450, family 4, subfamily F, polypeptide 22
CYP7B1 cytochrome P450, family 7, subfamily B, polypeptide 1
DCLRE1C DNA cross-link repair 1C
DNASE1L3 deoxyribonuclease I-like 3
DSG4 desmoglein 4
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
EPOR erythropoietin receptor
FECH ferrochelatase
FH fumarate hydratase
HLA-DRA major histocompatibility complex, class II, DR alpha
HSD3B7 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
IL17F interleukin 17F
IL17RA interleukin 17 receptor A
IL2RG interleukin 2 receptor, gamma
IL31RA interleukin 31 receptor A
IL7R interleukin 7 receptor
JAK2 Janus kinase 2
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
LBR lamin B receptor
LIG4 ligase IV, DNA, ATP-dependent
LIPA lipase A, lysosomal acid, cholesterol esterase
LIPH lipase, member H
LIPN lipase, family member N
LPAR6 lysophosphatidic acid receptor 6
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
MMP1 matrix metallopeptidase 1
MPL MPL proto-oncogene, thrombopoietin receptor
MVK mevalonate kinase
NIPAL4 NIPA-like domain containing 4
NLRP3 NLR family, pyrin domain containing 3
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
OSMR oncostatin M receptor
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PEPD peptidase D
PKP1 plakophilin 1
PNPLA1 patatin-like phospholipase domain containing 1
PTPN3 protein tyrosine phosphatase, non-receptor type 3
RAG1 recombination activating gene 1
RAG2 recombination activating gene 2
RMRP RNA component of mitochondrial RNA processing endoribonuclease
RPL21 ribosomal protein L21
SCN9A sodium channel, voltage gated, type IX alpha subunit
SNRPE small nuclear ribonucleoprotein polypeptide E
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
TET2 tet methylcytosine dioxygenase 2
TGM1 transglutaminase 1
THPO thrombopoietin
TJP2 tight junction protein 2
TRAF3IP2 TRAF3 interacting protein 2
TRPV3 transient receptor potential cation channel, subfamily V, member 3