Pseudobulbar signs result from injury to an upper motor neuron lesion to the corticobulbar pathways in the pyramidal tract. Patients have difficulty chewing, swallowing and demonstrate slurred speech (often initial presentation) as well as abnormal behavioral symptoms such as inappropriate emotional outbursts of uncontrolled laughter or weeping etc. (Human Phenotype Ontology, HP_0002200)
12 genes associated with the pseudobulbar signs phenotype by mapping known disease genes to disease phenotypes from the HPO Gene-Disease Associations dataset.
