| Dataset | MPO Gene-Phenotype Associations |
| Category | disease or phenotype associations |
| Type | phenotype |
| Description | A common genetically determined, chronic, inflammatory skin disease characterized by rounded erythematous, dry, scaling patches. The lesions have a predilection for nails, scalp, genitalia, extensor surfaces, and the lumbosacral region. Accelerated epidermopoiesis is considered to be the fundamental pathologic feature in psoriasis. (Experimental Factor Ontology, EFO_0000676) |
| External Link | http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0001193 |
| Similar Terms | |
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8 gene mutations causing the psoriasis phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.
| Symbol | Name |
|---|---|
| IL17C | interleukin 17C |
| IL17RA | interleukin 17 receptor A |
| IL17RE | interleukin 17 receptor E |
| IL1RN | interleukin 1 receptor antagonist |
| IL36RN | interleukin 36 receptor antagonist |
| ITGB2 | integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) |
| LRIG1 | leucine-rich repeats and immunoglobulin-like domains 1 |
| PTPN6 | protein tyrosine phosphatase, non-receptor type 6 |
