pten Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description phosphatase and tensin homolog|This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded by this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. The use of a non-canonical (CUG) upstream initiation site produces a longer isoform that initiates translation with a leucine, and is thought to be preferentially associated with the mitochondrial inner membrane. This longer isoform may help regulate energy metabolism in the mitochondria. A pseudogene of this gene is found on chromosome 9. Alternative splicing and the use of multiple translation start codons results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2015] (NCBI Entrez Gene Database, 5728)
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Genes

378 genes co-occuring with the biological term pten in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ADM adrenomedullin
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT2 v-akt murine thymoma viral oncogene homolog 2
AKT3 v-akt murine thymoma viral oncogene homolog 3
ALOX15 arachidonate 15-lipoxygenase
APC adenomatous polyposis coli
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
AR androgen receptor
ARL4A ADP-ribosylation factor-like 4A
ARRB1 arrestin, beta 1
ARRB2 arrestin, beta 2
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
ATF2 activating transcription factor 2
ATRX alpha thalassemia/mental retardation syndrome X-linked
ATXN3 ataxin 3
BAX BCL2-associated X protein
BCL2 B-cell CLL/lymphoma 2
BCL2L1 BCL2-like 1
BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB
BIRC5 baculoviral IAP repeat containing 5
BIRC7 baculoviral IAP repeat containing 7
BMI1 BMI1 proto-oncogene, polycomb ring finger
BMP2 bone morphogenetic protein 2
BMP4 bone morphogenetic protein 4
BMPR1A bone morphogenetic protein receptor, type IA
BNIPL BCL2/adenovirus E1B 19kD interacting protein like
BPIFA1 BPI fold containing family A, member 1
BRAF B-Raf proto-oncogene, serine/threonine kinase
BRCA1 breast cancer 1, early onset
BRCA2 breast cancer 2, early onset
BRMS1 breast cancer metastasis suppressor 1
CASP3 caspase 3, apoptosis-related cysteine peptidase
CAV1 caveolin 1, caveolae protein, 22kDa
CCND1 cyclin D1
CCND3 cyclin D3
CCNE2 cyclin E2
CD2 CD2 molecule
CD24 CD24 molecule
CD274 CD274 molecule
CD28 CD28 molecule
CD44 CD44 molecule (Indian blood group)
CDA cytidine deaminase
CDC42 cell division cycle 42
CDC6 cell division cycle 6
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CDX2 caudal type homeobox 2
CFL1 cofilin 1 (non-muscle)
CFLAR CASP8 and FADD-like apoptosis regulator
CHEK1 checkpoint kinase 1
CHGA chromogranin A
CHGB chromogranin B
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CLDN2 claudin 2
COL1A1 collagen, type I, alpha 1
CPEB1 cytoplasmic polyadenylation element binding protein 1
CREB1 cAMP responsive element binding protein 1
CREBBP CREB binding protein
CSF1 colony stimulating factor 1 (macrophage)
CSNK1E casein kinase 1, epsilon
CSNK2A1 casein kinase 2, alpha 1 polypeptide
CTGF connective tissue growth factor
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR4 chemokine (C-X-C motif) receptor 4
CYLD cylindromatosis (turban tumor syndrome)
DAPK1 death-associated protein kinase 1
DIABLO diablo, IAP-binding mitochondrial protein
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLC1 DLC1 Rho GTPase activating protein
DLG1 discs, large homolog 1 (Drosophila)
DNMT1 DNA (cytosine-5-)-methyltransferase 1
DROSHA drosha, ribonuclease type III
EDN1 endothelin 1
EDNRB endothelin receptor type B
EGFR epidermal growth factor receptor
EGR1 early growth response 1
EMX2 empty spiracles homeobox 2
EPAS1 endothelial PAS domain protein 1
EPHB1 EPH receptor B1
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
ERBB4 erb-b2 receptor tyrosine kinase 4
ERCC1 excision repair cross-complementation group 1
ERG v-ets avian erythroblastosis virus E26 oncogene homolog
ESR1 estrogen receptor 1
ESR2 estrogen receptor 2 (ER beta)
ESRRA estrogen-related receptor alpha
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
ETV1 ets variant 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
F3 coagulation factor III (thromboplastin, tissue factor)
FABP4 fatty acid binding protein 4, adipocyte
FAS Fas cell surface death receptor
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FGF2 fibroblast growth factor 2 (basic)
FGFR2 fibroblast growth factor receptor 2
FHIT fragile histidine triad
FOS FBJ murine osteosarcoma viral oncogene homolog
FOXC1 forkhead box C1
FOXO1 forkhead box O1
FRK fyn-related Src family tyrosine kinase
GATA2 GATA binding protein 2
GATA6 GATA binding protein 6
GLTSCR2 glioma tumor suppressor candidate region gene 2
GRP gastrin-releasing peptide
GSK3B glycogen synthase kinase 3 beta
HDAC1 histone deacetylase 1
HDAC2 histone deacetylase 2
HDAC4 histone deacetylase 4
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2)
HOTAIR HOX transcript antisense RNA
HRAS Harvey rat sarcoma viral oncogene homolog
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPB1 heat shock 27kDa protein 1
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
ICAM1 intercellular adhesion molecule 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF1R insulin-like growth factor 1 receptor
IGF2 insulin-like growth factor 2
IGF2BP1 insulin-like growth factor 2 mRNA binding protein 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP3 insulin-like growth factor binding protein 3
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
IL1RN interleukin 1 receptor antagonist
ILK integrin-linked kinase
ING4 inhibitor of growth family, member 4
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
INPP5D inositol polyphosphate-5-phosphatase, 145kDa
INPPL1 inositol polyphosphate phosphatase-like 1
IPCEF1 interaction protein for cytohesin exchange factors 1
IRS1 insulin receptor substrate 1
JUN jun proto-oncogene
KDM1A lysine (K)-specific demethylase 1A
KEAP1 kelch-like ECH-associated protein 1
KLK3 kallikrein-related peptidase 3
KLLN killin, p53-regulated DNA replication inhibitor
KMT2D lysine (K)-specific methyltransferase 2D
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRAS Kirsten rat sarcoma viral oncogene homolog
KRT10 keratin 10, type I
LEF1 lymphoid enhancer-binding factor 1
LEP leptin
LEPR leptin receptor
LGALS3 lectin, galactoside-binding, soluble, 3
LLGL1 lethal giant larvae homolog 1 (Drosophila)
MADD MAP-kinase activating death domain
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2
MAN2C1 mannosidase, alpha, class 2C, member 1
MAP2K1 mitogen-activated protein kinase kinase 1
MAP2K4 mitogen-activated protein kinase kinase 4
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MAPKAP1 mitogen-activated protein kinase associated protein 1
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
MCM7 minichromosome maintenance complex component 7
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MEF2A myocyte enhancer factor 2A
MET MET proto-oncogene, receptor tyrosine kinase
MGMT O-6-methylguanine-DNA methyltransferase
MIB1 mindbomb E3 ubiquitin protein ligase 1
MIR103A1 microRNA 103a-1
MIR103A2 microRNA 103a-2
MIR103B1 microRNA 103b-1
MIR103B2 microRNA 103b-2
MIR106B microRNA 106b
MIR10A microRNA 10a
MIR10B microRNA 10b
MIR125A microRNA 125a
MIR1297 microRNA 1297
MIR130B microRNA 130b
MIR148A microRNA 148a
MIR153-1 microRNA 153-1
MIR155 microRNA 155
MIR17 microRNA 17
MIR17HG miR-17-92 cluster host gene
MIR181A1 microRNA 181a-1
MIR181A2 microRNA 181a-2
MIR181B1 microRNA 181b-1
MIR183 microRNA 183
MIR185 microRNA 185
MIR18A microRNA 18a
MIR200A microRNA 200a
MIR200C microRNA 200c
MIR203A microRNA 203a
MIR205 microRNA 205
MIR20B microRNA 20b
MIR21 microRNA 21
MIR214 microRNA 214
MIR216A microRNA 216a
MIR22 microRNA 22
MIR221 microRNA 221
MIR222 microRNA 222
MIR23A microRNA 23a
MIR23B microRNA 23b
MIR26A1 microRNA 26a-1
MIR29A microRNA 29a
MIR29B1 microRNA 29b-1
MIR301A microRNA 301a
MIR31 microRNA 31
MIR32 microRNA 32
MIR519D microRNA 519d
MIR92B microRNA 92b
MIR93 microRNA 93
MITF microphthalmia-associated transcription factor
MLH1 mutL homolog 1
MMP1 matrix metallopeptidase 1
MMP2 matrix metallopeptidase 2
MMP3 matrix metallopeptidase 3
MMP7 matrix metallopeptidase 7
MMP9 matrix metallopeptidase 9
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MSH2 mutS homolog 2
MT1G metallothionein 1G
MTAP methylthioadenosine phosphorylase
MTM1 myotubularin 1
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MUC2 mucin 2, oligomeric mucus/gel-forming
MVP major vault protein
MXD1 MAX dimerization protein 1
MXI1 MAX interactor 1, dimerization protein
MYC v-myc avian myelocytomatosis viral oncogene homolog
NBN nibrin
NCOA3 nuclear receptor coactivator 3
NDRG1 N-myc downstream regulated 1
NDRG2 NDRG family member 2
NDUFB8 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
NF1 neurofibromin 1
NF2 neurofibromin 2 (merlin)
NFE2L2 nuclear factor, erythroid 2-like 2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NKX3-1 NK3 homeobox 1
NOTCH1 notch 1
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NR2E1 nuclear receptor subfamily 2, group E, member 1
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
NRP2 neuropilin 2
ODAM odontogenic, ameloblast asssociated
OLIG2 oligodendrocyte lineage transcription factor 2
PARK2 parkin RBR E3 ubiquitin protein ligase
PARK7 parkinson protein 7
PARP1 poly (ADP-ribose) polymerase 1
PAWR PRKC, apoptosis, WT1, regulator
PAX2 paired box 2
PAX8 paired box 8
PCAT4 prostate cancer associated transcript 4 (non-protein coding)
PDCD1 programmed cell death 1
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDPK1 3-phosphoinositide dependent protein kinase 1
PDPN podoplanin
PEA15 phosphoprotein enriched in astrocytes 15
PF4 platelet factor 4
PGR progesterone receptor
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1
PIAS2 protein inhibitor of activated STAT, 2
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PINK1 PTEN induced putative kinase 1
PKN3 protein kinase N3
PLK1 polo-like kinase 1
PLK3 polo-like kinase 3
PLXNB1 plexin B1
PML promyelocytic leukemia
PNKP polynucleotide kinase 3'-phosphatase
POLR1B polymerase (RNA) I polypeptide B, 128kDa
PPARD peroxisome proliferator-activated receptor delta
PPARG peroxisome proliferator-activated receptor gamma
PPM1A protein phosphatase, Mg2+/Mn2+ dependent, 1A
PPP1R10 protein phosphatase 1, regulatory subunit 10
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme
PPP2R2B protein phosphatase 2, regulatory subunit B, beta
PREX2 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
PRKCA protein kinase C, alpha
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PTEN phosphatase and tensin homolog
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa
PTGES prostaglandin E synthase
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTK2 protein tyrosine kinase 2
PTPN1 protein tyrosine phosphatase, non-receptor type 1
PTPN2 protein tyrosine phosphatase, non-receptor type 2
PTPRA protein tyrosine phosphatase, receptor type, A
PTPRJ protein tyrosine phosphatase, receptor type, J
PTTG1 pituitary tumor-transforming 1
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RAD52 RAD52 homolog (S. cerevisiae)
RAG1 recombination activating gene 1
RAN RAN, member RAS oncogene family
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RB1 retinoblastoma 1
RBPJ recombination signal binding protein for immunoglobulin kappa J region
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RETN resistin
RHOA ras homolog family member A
RICTOR RPTOR independent companion of MTOR, complex 2
RNH1 ribonuclease/angiogenin inhibitor 1
ROCK1 Rho-associated, coiled-coil containing protein kinase 1
ROCK2 Rho-associated, coiled-coil containing protein kinase 2
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
RPTOR regulatory associated protein of MTOR, complex 1
RRM1 ribonucleotide reductase M1
RSL1D1 ribosomal L1 domain containing 1
RUNX2 runt-related transcription factor 2
S1PR2 sphingosine-1-phosphate receptor 2
SALL1 spalt-like transcription factor 1
SALL4 spalt-like transcription factor 4
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SHARPIN SHANK-associated RH domain interactor
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SHH sonic hedgehog
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SMAD1 SMAD family member 1
SMAD2 SMAD family member 2
SMAD3 SMAD family member 3
SMAD4 SMAD family member 4
SNAI1 snail family zinc finger 1
SOCS3 suppressor of cytokine signaling 3
SOD1 superoxide dismutase 1, soluble
SOD2 superoxide dismutase 2, mitochondrial
SP1 Sp1 transcription factor
SPP1 secreted phosphoprotein 1
SPRY2 sprouty homolog 2 (Drosophila)
SREBF1 sterol regulatory element binding transcription factor 1
SRRT serrate, RNA effector molecule
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STK11 serine/threonine kinase 11
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
SULF1 sulfatase 1
SUMO1 small ubiquitin-like modifier 1
TAF1C TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa
TAF5L TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa
TBX3 T-box 3
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TGFA transforming growth factor, alpha
TGFB1 transforming growth factor, beta 1
TGM2 transglutaminase 2
THBS2 thrombospondin 2
TIMP1 TIMP metallopeptidase inhibitor 1
TIMP2 TIMP metallopeptidase inhibitor 2
TIMP3 TIMP metallopeptidase inhibitor 3
TNF tumor necrosis factor
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOB1 transducer of ERBB2, 1
TOP2A topoisomerase (DNA) II alpha 170kDa
TP53 tumor protein p53
TP63 tumor protein p63
TP73 tumor protein p73
TPTE2 transmembrane phosphoinositide 3-phosphatase and tensin homolog 2
TRIM27 tripartite motif containing 27
TRPC6 transient receptor potential cation channel, subfamily C, member 6
TXN thioredoxin
USP13 ubiquitin specific peptidase 13 (isopeptidase T-3)
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
VCAM1 vascular cell adhesion molecule 1
VEGFA vascular endothelial growth factor A
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
YY1 YY1 transcription factor