ptgs2 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)|Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes the inducible isozyme. It is regulated by specific stimulatory events, suggesting that it is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis. [provided by RefSeq, Feb 2009] (NCBI Entrez Gene Database, 5743)
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Genes

32 genes co-occuring with the biological term ptgs2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
AGTR1 angiotensin II receptor, type 1
CCK cholecystokinin
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CTGF connective tissue growth factor
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CXCL8 chemokine (C-X-C motif) ligand 8
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
EGFR epidermal growth factor receptor
ERCC5 excision repair cross-complementation group 5
GJA1 gap junction protein, alpha 1, 43kDa
GPX3 glutathione peroxidase 3
HNRNPK heterogeneous nuclear ribonucleoprotein K
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IL6 interleukin 6
LTA lymphotoxin alpha
MIR146A microRNA 146a
MMP19 matrix metallopeptidase 19
MMP3 matrix metallopeptidase 3
NAMPT nicotinamide phosphoribosyltransferase
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
SOD2 superoxide dismutase 2, mitochondrial
SPHK1 sphingosine kinase 1
STAT5A signal transducer and activator of transcription 5A
TLR2 toll-like receptor 2
TLR4 toll-like receptor 4
TNF tumor necrosis factor