ptpn11 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description protein tyrosine phosphatase, non-receptor type 11|The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012] (NCBI Entrez Gene Database, 5781)
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Genes

26 genes co-occuring with the biological term ptpn11 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
AKT1 v-akt murine thymoma viral oncogene homolog 1
BRAF B-Raf proto-oncogene, serine/threonine kinase
FBN1 fibrillin 1
FLT3 fms-related tyrosine kinase 3
GATA2 GATA binding protein 2
GSK3B glycogen synthase kinase 3 beta
HRAS Harvey rat sarcoma viral oncogene homolog
IGF1 insulin-like growth factor 1 (somatomedin C)
IL10 interleukin 10
JUN jun proto-oncogene
KRAS Kirsten rat sarcoma viral oncogene homolog
KSR1 kinase suppressor of ras 1
MAP2K1 mitogen-activated protein kinase kinase 1
MAP2K2 mitogen-activated protein kinase kinase 2
MIR489 microRNA 489
NF1 neurofibromin 1
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NQO1 NAD(P)H dehydrogenase, quinone 1
PGC progastricsin (pepsinogen C)
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PTPN1 protein tyrosine phosphatase, non-receptor type 1
PTPN11 protein tyrosine phosphatase, non-receptor type 11
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
SOS1 son of sevenless homolog 1 (Drosophila)
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)