pyrantel-2260 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the pyrantel-2260 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AAGAB alpha- and gamma-adaptin binding protein
ADGRB2 adhesion G protein-coupled receptor B2
ANGPT4 angiopoietin 4
ANPEP alanyl (membrane) aminopeptidase
ATN1 atrophin 1
ATP2A1 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1
BET1L Bet1 golgi vesicular membrane trafficking protein-like
BTBD7 BTB (POZ) domain containing 7
CABP2 calcium binding protein 2
CACNG1 calcium channel, voltage-dependent, gamma subunit 1
CAMK2B calcium/calmodulin-dependent protein kinase II beta
CBX2 chromobox homolog 2
CD1E CD1e molecule
CHAT choline O-acetyltransferase
CNTNAP2 contactin associated protein-like 2
COL13A1 collagen, type XIII, alpha 1
COL5A2 collagen, type V, alpha 2
CTSF cathepsin F
CUL7 cullin 7
DOK4 docking protein 4
DVL3 dishevelled segment polarity protein 3
FAIM2 Fas apoptotic inhibitory molecule 2
FAM46C family with sequence similarity 46, member C
FBXL18 F-box and leucine-rich repeat protein 18
FGFBP1 fibroblast growth factor binding protein 1
FGFR1 fibroblast growth factor receptor 1
FGFR3 fibroblast growth factor receptor 3
FRMD4A FERM domain containing 4A
FRMD4B FERM domain containing 4B
FUT3 fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group)
FZD9 frizzled class receptor 9
HAO2 hydroxyacid oxidase 2 (long chain)
HDAC11 histone deacetylase 11
HMGN5 high mobility group nucleosome binding domain 5
HOXB2 homeobox B2
HUS1 HUS1 checkpoint homolog (S. pombe)
ICAM2 intercellular adhesion molecule 2
IFT27 intraflagellar transport 27
IFT54 intraflagellar transport 54
ITGA8 integrin, alpha 8
ITM2C integral membrane protein 2C
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
JAM3 junctional adhesion molecule 3
KIR2DL1 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1
KLK2 kallikrein-related peptidase 2
KMT2A lysine (K)-specific methyltransferase 2A
LRRK1 leucine-rich repeat kinase 1
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2
MID1 midline 1
MZF1 myeloid zinc finger 1
NF2 neurofibromin 2 (merlin)
NPIPB3 nuclear pore complex interacting protein family, member B3
NR2E3 nuclear receptor subfamily 2, group E, member 3
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR6A1 nuclear receptor subfamily 6, group A, member 1
NT5M 5',3'-nucleotidase, mitochondrial
NUDCD3 NudC domain containing 3
OR10J1 olfactory receptor, family 10, subfamily J, member 1
OSBP2 oxysterol binding protein 2
PDE9A phosphodiesterase 9A
PDGFD platelet derived growth factor D
PI4K2A phosphatidylinositol 4-kinase type 2 alpha
PIGR polymeric immunoglobulin receptor
PLK3 polo-like kinase 3
PML promyelocytic leukemia
PRB1 proline-rich protein BstNI subfamily 1
PRDM10 PR domain containing 10
PRDM2 PR domain containing 2, with ZNF domain
PTAFR platelet-activating factor receptor
RAB6A RAB6A, member RAS oncogene family
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RASGRP2 RAS guanyl releasing protein 2 (calcium and DAG-regulated)
SERHL2 serine hydrolase-like 2
SFI1 Sfi1 homolog, spindle assembly associated (yeast)
SFRP5 secreted frizzled-related protein 5
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
SLC2A11 solute carrier family 2 (facilitated glucose transporter), member 11
SLCO1A2 solute carrier organic anion transporter family, member 1A2
SNAP25 synaptosomal-associated protein, 25kDa
SOS2 son of sevenless homolog 2 (Drosophila)
SOX2 SRY (sex determining region Y)-box 2
TBXA2R thromboxane A2 receptor
TEX15 testis expressed 15
TIMP3 TIMP metallopeptidase inhibitor 3
TMPRSS2 transmembrane protease, serine 2
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B
TNS1 tensin 1
TNXB tenascin XB
TP53I11 tumor protein p53 inducible protein 11
TRPC1 transient receptor potential cation channel, subfamily C, member 1
TUBB7P tubulin, beta 7, pseudogene
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UPF3A UPF3 regulator of nonsense transcripts homolog A (yeast)
VIPR1 vasoactive intestinal peptide receptor 1
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble
ZNF589 zinc finger protein 589
ZNF646 zinc finger protein 646
ZNF682 zinc finger protein 682
ZNF750 zinc finger protein 750

decreased expression

Symbol Name
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ANXA2P3 annexin A2 pseudogene 3
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1
B3GALT4 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4
BATF basic leucine zipper transcription factor, ATF-like
C22ORF46 chromosome 22 open reading frame 46
C7ORF43 chromosome 7 open reading frame 43
C9ORF9 chromosome 9 open reading frame 9
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CALML5 calmodulin-like 5
CCRN4L CCR4 carbon catabolite repression 4-like (S. cerevisiae)
CD83 CD83 molecule
CPPED1 calcineurin-like phosphoesterase domain containing 1
CXXC4 CXXC finger protein 4
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DUSP9 dual specificity phosphatase 9
ERCC4 excision repair cross-complementation group 4
EXD3 exonuclease 3'-5' domain containing 3
FAM212B family with sequence similarity 212, member B
FAM76A family with sequence similarity 76, member A
FARP2 FERM, RhoGEF and pleckstrin domain protein 2
FBXL7 F-box and leucine-rich repeat protein 7
FGD1 FYVE, RhoGEF and PH domain containing 1
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2
GFI1 growth factor independent 1 transcription repressor
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GTF2H3 general transcription factor IIH, polypeptide 3, 34kDa
GUSBP3 glucuronidase, beta pseudogene 3
HAUS2 HAUS augmin-like complex, subunit 2
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HIST1H1D histone cluster 1, H1d
HIST1H2AL histone cluster 1, H2al
HOXC4 homeobox C4
HOXC8 homeobox C8
IGSF1 immunoglobulin superfamily, member 1
INPP5J inositol polyphosphate-5-phosphatase J
IPO8 importin 8
JPH3 junctophilin 3
KDM8 lysine (K)-specific demethylase 8
KLK5 kallikrein-related peptidase 5
LRP2 low density lipoprotein receptor-related protein 2
MALL mal, T-cell differentiation protein-like
MAPK10 mitogen-activated protein kinase 10
MBTD1 mbt domain containing 1
MED18 mediator complex subunit 18
MMP3 matrix metallopeptidase 3
MTCP1 mature T-cell proliferation 1
MVP major vault protein
NR1D2 nuclear receptor subfamily 1, group D, member 2
NRSN2 neurensin 2
NT5DC3 5'-nucleotidase domain containing 3
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)
PAIP2B poly(A) binding protein interacting protein 2B
PLA2G3 phospholipase A2, group III
PLA2G4C phospholipase A2, group IVC (cytosolic, calcium-independent)
PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2
PLEKHG6 pleckstrin homology domain containing, family G (with RhoGef domain) member 6
POM121 POM121 transmembrane nucleoporin
PRICKLE3 prickle homolog 3 (Drosophila)
PRODH proline dehydrogenase (oxidase) 1
PRR14L proline rich 14-like
PRR4 proline rich 4 (lacrimal)
PTPRCAP protein tyrosine phosphatase, receptor type, C-associated protein
PTPRS protein tyrosine phosphatase, receptor type, S
PYHIN1 pyrin and HIN domain family, member 1
RAB3A RAB3A, member RAS oncogene family
RNF122 ring finger protein 122
RPL10L ribosomal protein L10-like
SAYSD1 SAYSVFN motif domain containing 1
SCAMP5 secretory carrier membrane protein 5
SLC16A7 solute carrier family 16 (monocarboxylate transporter), member 7
SLC30A3 solute carrier family 30 (zinc transporter), member 3
SLC43A1 solute carrier family 43 (amino acid system L transporter), member 1
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SNTA1 syntrophin, alpha 1
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma)
STAG3 stromal antigen 3
STMN3 stathmin-like 3
TBKBP1 TBK1 binding protein 1
TM6SF1 transmembrane 6 superfamily member 1
TMEM159 transmembrane protein 159
TMEM209 transmembrane protein 209
TMPRSS4 transmembrane protease, serine 4
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator
TRMT2B tRNA methyltransferase 2 homolog B (S. cerevisiae)
TSPAN5 tetraspanin 5
VASH2 vasohibin 2
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae)
XDH xanthine dehydrogenase
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2
ZBTB33 zinc finger and BTB domain containing 33
ZFHX3 zinc finger homeobox 3
ZIC3 Zic family member 3
ZNF136 zinc finger protein 136
ZNF205 zinc finger protein 205
ZNF219 zinc finger protein 219
ZNF329 zinc finger protein 329