pyrantel Gene Set
Genes
35 genes differentially expressed following the pyrantel small molecule perturbation from the LINCS L1000 CMAP Chemical Perturbation Consensus Signatures dataset.
increased expression
| Symbol |
Name |
Standardized Value |
|
CDC42
|
cell division cycle 42
|
3.68178
|
|
SYNM
|
synemin, intermediate filament protein
|
3.63966
|
|
POLR2I
|
polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
|
3.61821
|
|
NFKBIB
|
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
|
3.53529
|
|
TPST1
|
tyrosylprotein sulfotransferase 1
|
3.29979
|
|
GNA12
|
guanine nucleotide binding protein (G protein) alpha 12
|
3.29506
|
|
U2AF2
|
U2 small nuclear RNA auxiliary factor 2
|
3.27955
|
|
PRKAA2
|
protein kinase, AMP-activated, alpha 2 catalytic subunit
|
3.27792
|
|
RRP8
|
ribosomal RNA processing 8, methyltransferase, homolog (yeast)
|
3.26505
|
|
CRYGB
|
crystallin, gamma B
|
3.26007
|
|
DNAJC12
|
DnaJ (Hsp40) homolog, subfamily C, member 12
|
3.12402
|
|
ITCH
|
itchy E3 ubiquitin protein ligase
|
3.12074
|
|
DLK1
|
delta-like 1 homolog (Drosophila)
|
3.10275
|
|
BCAS1
|
breast carcinoma amplified sequence 1
|
3.06435
|
|
CANT1
|
calcium activated nucleotidase 1
|
3.0188
|
|
PGK2
|
phosphoglycerate kinase 2
|
3.01771
|
decreased expression
| Symbol |
Name |
Standardized Value |
|
MED31
|
mediator complex subunit 31
|
-4.67571
|
|
STUB1
|
STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
|
-4.04644
|
|
ARHGEF15
|
Rho guanine nucleotide exchange factor (GEF) 15
|
-3.8183
|
|
TRAPPC3
|
trafficking protein particle complex 3
|
-3.77253
|
|
FZD8
|
frizzled class receptor 8
|
-3.67388
|
|
TACR3
|
tachykinin receptor 3
|
-3.66396
|
|
C2ORF27A
|
chromosome 2 open reading frame 27A
|
-3.48027
|
|
PSAP
|
prosaposin
|
-3.45722
|
|
CADM3-AS1
|
CADM3 antisense RNA 1
|
-3.29623
|
|
MRPS18C
|
mitochondrial ribosomal protein S18C
|
-3.2748
|
|
EPB41
|
erythrocyte membrane protein band 4.1
|
-3.25682
|
|
GP2
|
glycoprotein 2 (zymogen granule membrane)
|
-3.22762
|
|
MTOR
|
mechanistic target of rapamycin (serine/threonine kinase)
|
-3.15581
|
|
KANSL3
|
KAT8 regulatory NSL complex subunit 3
|
-3.13782
|
|
ITGAX
|
integrin, alpha X (complement component 3 receptor 4 subunit)
|
-3.12026
|
|
SLC22A14
|
solute carrier family 22, member 14
|
-3.09699
|
|
NCF2
|
neutrophil cytosolic factor 2
|
-3.07061
|
|
ZNF549
|
zinc finger protein 549
|
-3.06995
|
|
ATXN8OS
|
ATXN8 opposite strand (non-protein coding)
|
-3.05347
|
