pyrazinamide-2478 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

194 genes differentially expressed following the pyrazinamide-2478 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
A2M alpha-2-macroglobulin
ACVR1B activin A receptor, type IB
ADGRD2 adhesion G protein-coupled receptor D2
AIM1L absent in melanoma 1-like
AKAP13 A kinase (PRKA) anchor protein 13
ALG12 ALG12, alpha-1,6-mannosyltransferase
ANGPTL2 angiopoietin-like 2
AQP9 aquaporin 9
ATP10A ATPase, class V, type 10A
BLZF1 basic leucine zipper nuclear factor 1
BTD biotinidase
CACNB1 calcium channel, voltage-dependent, beta 1 subunit
CLMN calmin (calponin-like, transmembrane)
CNN1 calponin 1, basic, smooth muscle
COL10A1 collagen, type X, alpha 1
COLQ collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
DAPK3 death-associated protein kinase 3
DCT dopachrome tautomerase
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6
DENND5B DENN/MADD domain containing 5B
DLG4 discs, large homolog 4 (Drosophila)
DNASE2B deoxyribonuclease II beta
DUSP4 dual specificity phosphatase 4
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2
ERBB2 erb-b2 receptor tyrosine kinase 2
EVX1 even-skipped homeobox 1
EXTL3 exostosin-like glycosyltransferase 3
FADS3 fatty acid desaturase 3
FXYD2 FXYD domain containing ion transport regulator 2
GLI3 GLI family zinc finger 3
GLIPR1 GLI pathogenesis-related 1
GPR22 G protein-coupled receptor 22
GPR35 G protein-coupled receptor 35
HBZ hemoglobin, zeta
HIST2H2AA3 histone cluster 2, H2aa3
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HOXA11 homeobox A11
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IHH indian hedgehog
IL2RB interleukin 2 receptor, beta
IL6ST interleukin 6 signal transducer
INO80B INO80 complex subunit B
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5
KCNQ3 potassium channel, voltage gated KQT-like subfamily Q, member 3
KIAA1644 KIAA1644
KIF5C kinesin family member 5C
KLHL35 kelch-like family member 35
LAG3 lymphocyte-activation gene 3
LAMP3 lysosomal-associated membrane protein 3
MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3
MARC1 mitochondrial amidoxime reducing component 1
MAX MYC associated factor X
MBL1P mannose-binding lectin (protein A) 1, pseudogene
MXD4 MAX dimerization protein 4
MYBPH myosin binding protein H
NDUFAF5 NADH dehydrogenase (ubiquinone) complex I, assembly factor 5
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NPEPL1 aminopeptidase-like 1
OLAH oleoyl-ACP hydrolase
OPRK1 opioid receptor, kappa 1
PLA2G16 phospholipase A2, group XVI
PPP1R12B protein phosphatase 1, regulatory subunit 12B
PPP1R13L protein phosphatase 1, regulatory subunit 13 like
PPP5C protein phosphatase 5, catalytic subunit
PTGER1 prostaglandin E receptor 1 (subtype EP1), 42kDa
RAB11B RAB11B, member RAS oncogene family
RANBP3 RAN binding protein 3
REEP2 receptor accessory protein 2
RQCD1 RCD1 required for cell differentiation1 homolog (S. pombe)
RUFY3 RUN and FYVE domain containing 3
RUNDC3A RUN domain containing 3A
SEMA6B sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B
SFRP4 secreted frizzled-related protein 4
SIPA1L3 signal-induced proliferation-associated 1 like 3
SLC13A3 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa
SOGA1 suppressor of glucose, autophagy associated 1
SOX15 SRY (sex determining region Y)-box 15
SPATA1 spermatogenesis associated 1
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SSH3 slingshot protein phosphatase 3
STS steroid sulfatase (microsomal), isozyme S
SYT12 synaptotagmin XII
TAPBP TAP binding protein (tapasin)
TAS2R4 taste receptor, type 2, member 4
TBC1D2 TBC1 domain family, member 2
TMEM180 transmembrane protein 180
TMEM19 transmembrane protein 19
TRAF2 TNF receptor-associated factor 2
TSPAN9 tetraspanin 9
ULBP2 UL16 binding protein 2
USP12 ubiquitin specific peptidase 12
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
ZNF365 zinc finger protein 365

decreased expression

Symbol Name
A1CF APOBEC1 complementation factor
ABCB4 ATP-binding cassette, sub-family B (MDR/TAP), member 4
AGPAT4 1-acylglycerol-3-phosphate O-acyltransferase 4
ALS2CL ALS2 C-terminal like
ANXA2P2 annexin A2 pseudogene 2
AUP1 ancient ubiquitous protein 1
BGLAP bone gamma-carboxyglutamate (gla) protein
BSPRY B-box and SPRY domain containing
C17ORF53 chromosome 17 open reading frame 53
CCDC176 coiled-coil domain containing 176
CDC73 cell division cycle 73
CPPED1 calcineurin-like phosphoesterase domain containing 1
CRY2 cryptochrome circadian clock 2
CTDSP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1
CYB5R1 cytochrome b5 reductase 1
DHRS3 dehydrogenase/reductase (SDR family) member 3
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DNM3 dynamin 3
DOC2A double C2-like domains, alpha
DOCK4 dedicator of cytokinesis 4
DPEP2 dipeptidase 2
DPY19L2P2 DPY19L2 pseudogene 2
EML4 echinoderm microtubule associated protein like 4
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7
ERCC2 excision repair cross-complementation group 2
ERO1LB ERO1-like beta (S. cerevisiae)
FADD Fas (TNFRSF6)-associated via death domain
FBP1 fructose-1,6-bisphosphatase 1
FBXO31 F-box protein 31
FBXW4P1 F-box and WD repeat domain containing 4 pseudogene 1
FCHO1 FCH domain only 1
GAB2 GRB2-associated binding protein 2
GMEB1 glucocorticoid modulatory element binding protein 1
GSTA4 glutathione S-transferase alpha 4
HAAO 3-hydroxyanthranilate 3,4-dioxygenase
HIST1H2BE histone cluster 1, H2be
IER3IP1 immediate early response 3 interacting protein 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IL3RA interleukin 3 receptor, alpha (low affinity)
IMPDH1 IMP (inosine 5'-monophosphate) dehydrogenase 1
INCENP inner centromere protein antigens 135/155kDa
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
KIAA1024 KIAA1024
LIN7B lin-7 homolog B (C. elegans)
LOC100287590 uncharacterized LOC100287590
LY6G6C lymphocyte antigen 6 complex, locus G6C
LYRM1 LYR motif containing 1
MAP2K1 mitogen-activated protein kinase kinase 1
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
MEGF8 multiple EGF-like-domains 8
MRAS muscle RAS oncogene homolog
MYO19 myosin XIX
NDRG3 NDRG family member 3
NECAB3 N-terminal EF-hand calcium binding protein 3
PCNP PEST proteolytic signal containing nuclear protein
PITX2 paired-like homeodomain 2
PRKCZ protein kinase C, zeta
PROCR protein C receptor, endothelial
PYGB phosphorylase, glycogen; brain
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RAD51AP1 RAD51 associated protein 1
RARS arginyl-tRNA synthetase
RBM47 RNA binding motif protein 47
RFPL1S RFPL1 antisense RNA 1
RNF31 ring finger protein 31
SCML2 sex comb on midleg-like 2 (Drosophila)
SERGEF secretion regulating guanine nucleotide exchange factor
SHFM1 split hand/foot malformation (ectrodactyly) type 1
SIGLEC15 sialic acid binding Ig-like lectin 15
SLC25A22 solute carrier family 25 (mitochondrial carrier: glutamate), member 22
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae)
SURF2 surfeit 2
TAOK1 TAO kinase 1
TCTN2 tectonic family member 2
TEC tec protein tyrosine kinase
TET3 tet methylcytosine dioxygenase 3
TIAM2 T-cell lymphoma invasion and metastasis 2
TMOD3 tropomodulin 3 (ubiquitous)
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain
TRIM16 tripartite motif containing 16
TRIM8 tripartite motif containing 8
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TTC4 tetratricopeptide repeat domain 4
TTPAL tocopherol (alpha) transfer protein-like
TUBA3C tubulin, alpha 3c
TUBA4B tubulin, alpha 4b
UPK3A uroplakin 3A
USB1 U6 snRNA biogenesis 1
WDR60 WD repeat domain 60
WDR91 WD repeat domain 91
YY2 YY2 transcription factor
ZBTB22 zinc finger and BTB domain containing 22
ZNF227 zinc finger protein 227
ZNF354A zinc finger protein 354A
ZNF862 zinc finger protein 862