pyrazinamide-4962 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the pyrazinamide-4962 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAM8 ADAM metallopeptidase domain 8
AK1 adenylate kinase 1
ARR3 arrestin 3, retinal (X-arrestin)
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
B9D2 B9 protein domain 2
BAZ1B bromodomain adjacent to zinc finger domain, 1B
BRINP2 bone morphogenetic protein/retinoic acid inducible neural-specific 2
C1QB complement component 1, q subcomponent, B chain
CABIN1 calcineurin binding protein 1
CAMK4 calcium/calmodulin-dependent protein kinase IV
CD82 CD82 molecule
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEND1 cell cycle exit and neuronal differentiation 1
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal)
CHRNG cholinergic receptor, nicotinic, gamma (muscle)
CLCN7 chloride channel, voltage-sensitive 7
CORO7 coronin 7
CPB1 carboxypeptidase B1 (tissue)
CSHL1 chorionic somatomammotropin hormone-like 1
CTSO cathepsin O
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6
DEF6 differentially expressed in FDCP 6 homolog (mouse)
DLC1 DLC1 Rho GTPase activating protein
DOCK6 dedicator of cytokinesis 6
ELL2 elongation factor, RNA polymerase II, 2
ELN elastin
EMP1 epithelial membrane protein 1
EPHA1 EPH receptor A1
ERC2-IT1 ERC2 intronic transcript 1
ERO1LB ERO1-like beta (S. cerevisiae)
EXOSC1 exosome component 1
FGF18 fibroblast growth factor 18
FGF23 fibroblast growth factor 23
FMO5 flavin containing monooxygenase 5
FURIN furin (paired basic amino acid cleaving enzyme)
FYB FYN binding protein
GJB3 gap junction protein, beta 3, 31kDa
GLIPR1 GLI pathogenesis-related 1
GMPR guanosine monophosphate reductase
GPR137 G protein-coupled receptor 137
GRIP2 glutamate receptor interacting protein 2
GSTTP1 glutathione S-transferase theta pseudogene 1
HHAT hedgehog acyltransferase
HIPK2 homeodomain interacting protein kinase 2
HIST1H2AJ histone cluster 1, H2aj
HSPB11 heat shock protein family B (small), member 11
HTR1D 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled
IGHM immunoglobulin heavy constant mu
IL9R interleukin 9 receptor
INHBA inhibin, beta A
KIF13A kinesin family member 13A
KRTAP9-9 keratin associated protein 9-9
LAIR1 leukocyte-associated immunoglobulin-like receptor 1
LEFTY1 left-right determination factor 1
LRRC40 leucine rich repeat containing 40
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
LTBP2 latent transforming growth factor beta binding protein 2
MAL mal, T-cell differentiation protein
MAP1S microtubule-associated protein 1S
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
NOD2 nucleotide-binding oligomerization domain containing 2
NTF3 neurotrophin 3
OSGIN1 oxidative stress induced growth inhibitor 1
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4
PAX3 paired box 3
PCDHB13 protocadherin beta 13
PDCD6 programmed cell death 6
PDLIM5 PDZ and LIM domain 5
PI4K2A phosphatidylinositol 4-kinase type 2 alpha
PIK3R5 phosphoinositide-3-kinase, regulatory subunit 5
PKNOX2 PBX/knotted 1 homeobox 2
PLXNA2 plexin A2
PLXNB2 plexin B2
POFUT1 protein O-fucosyltransferase 1
PRKACG protein kinase, cAMP-dependent, catalytic, gamma
RGS12 regulator of G-protein signaling 12
RIF1 replication timing regulatory factor 1
S100A7 S100 calcium binding protein A7
SEMA3F sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
SFTPC surfactant protein C
SIDT2 SID1 transmembrane family, member 2
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SNRPN small nuclear ribonucleoprotein polypeptide N
SUGP1 SURP and G patch domain containing 1
SVEP1 sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
TFDP3 transcription factor Dp family, member 3
TP63 tumor protein p63
TRIM36 tripartite motif containing 36
TTC9 tetratricopeptide repeat domain 9
UBE3A ubiquitin protein ligase E3A
UNC93B1 unc-93 homolog B1 (C. elegans)
USP22 ubiquitin specific peptidase 22
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
WNT10B wingless-type MMTV integration site family, member 10B
ZBTB43 zinc finger and BTB domain containing 43
ZNF446 zinc finger protein 446
ZNF484 zinc finger protein 484
ZNF576 zinc finger protein 576
ZNF783 zinc finger family member 783

decreased expression

Symbol Name
ACVR2B activin A receptor, type IIB
ALPK1 alpha-kinase 1
AMT aminomethyltransferase
ANKZF1 ankyrin repeat and zinc finger domain containing 1
ANO10 anoctamin 10
ARID4A AT rich interactive domain 4A (RBP1-like)
ATP13A2 ATPase type 13A2
CABYR calcium binding tyrosine-(Y)-phosphorylation regulated
CDKL3 cyclin-dependent kinase-like 3
CHMP7 charged multivesicular body protein 7
CHRM3 cholinergic receptor, muscarinic 3
CHST10 carbohydrate sulfotransferase 10
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11
CLCN5 chloride channel, voltage-sensitive 5
CRABP1 cellular retinoic acid binding protein 1
CRYBG3 beta-gamma crystallin domain containing 3
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
DGCR11 DiGeorge syndrome critical region gene 11 (non-protein coding)
DNAJC24 DnaJ (Hsp40) homolog, subfamily C, member 24
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7
ERN2 endoplasmic reticulum to nucleus signaling 2
FAM86C1 family with sequence similarity 86, member C1
FANCE Fanconi anemia, complementation group E
FBXO31 F-box protein 31
FLRT3 fibronectin leucine rich transmembrane protein 3
FRS2 fibroblast growth factor receptor substrate 2
GBP2 guanylate binding protein 2, interferon-inducible
GLS2 glutaminase 2 (liver, mitochondrial)
GSTZ1 glutathione S-transferase zeta 1
HINFP histone H4 transcription factor
HIST1H1E histone cluster 1, H1e
HOXC10 homeobox C10
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IFT22 intraflagellar transport 22
IL15RA interleukin 15 receptor, alpha
IRF6 interferon regulatory factor 6
IRF9 interferon regulatory factor 9
ISG15 ISG15 ubiquitin-like modifier
ITPKB inositol-trisphosphate 3-kinase B
KCTD15 potassium channel tetramerization domain containing 15
KIAA0232 KIAA0232
LINC00115 long intergenic non-protein coding RNA 115
LZTS3 leucine zipper, putative tumor suppressor family member 3
MOSPD3 motile sperm domain containing 3
MYL5 myosin, light chain 5, regulatory
MYO1E myosin IE
NPM3 nucleophosmin/nucleoplasmin 3
NPY1R neuropeptide Y receptor Y1
NR1H3 nuclear receptor subfamily 1, group H, member 3
NRGN neurogranin (protein kinase C substrate, RC3)
PCSK7 proprotein convertase subtilisin/kexin type 7
PLCD1 phospholipase C, delta 1
PLD3 phospholipase D family, member 3
PMM1 phosphomannomutase 1
POLR3D polymerase (RNA) III (DNA directed) polypeptide D, 44kDa
PPAN peter pan homolog (Drosophila)
PRODH proline dehydrogenase (oxidase) 1
PRSS16 protease, serine, 16 (thymus)
PSKH1 protein serine kinase H1
PTPRU protein tyrosine phosphatase, receptor type, U
RBM42 RNA binding motif protein 42
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SIK1 salt-inducible kinase 1
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SLC26A6 solute carrier family 26 (anion exchanger), member 6
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SNHG3 small nucleolar RNA host gene 3
SPINK4 serine peptidase inhibitor, Kazal type 4
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STRN striatin, calmodulin binding protein
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
THUMPD2 THUMP domain containing 2
TMEM104 transmembrane protein 104
TMEM51 transmembrane protein 51
TOM1 target of myb1 (chicken)
TRAPPC2 trafficking protein particle complex 2
TRAPPC6A trafficking protein particle complex 6A
TSPAN1 tetraspanin 1
TSPO translocator protein (18kDa)
TSSC4 tumor suppressing subtransferable candidate 4
TTC26 tetratricopeptide repeat domain 26
TUBA3C tubulin, alpha 3c
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1
UBXN6 UBX domain protein 6
ULBP2 UL16 binding protein 2
USP18 ubiquitin specific peptidase 18
XYLT2 xylosyltransferase II
ZBTB48 zinc finger and BTB domain containing 48
ZC3H3 zinc finger CCCH-type containing 3
ZNF219 zinc finger protein 219
ZNF227 zinc finger protein 227
ZNF273 zinc finger protein 273
ZNF350 zinc finger protein 350
ZNF557 zinc finger protein 557
ZNF665 zinc finger protein 665
ZNF675 zinc finger protein 675