pyridoxine-7171 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

200 genes differentially expressed following the pyridoxine-7171 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
A2M alpha-2-macroglobulin
ABCB9 ATP-binding cassette, sub-family B (MDR/TAP), member 9
AGPAT2 1-acylglycerol-3-phosphate O-acyltransferase 2
ALOXE3 arachidonate lipoxygenase 3
AMACR alpha-methylacyl-CoA racemase
APOM apolipoprotein M
ARHGAP35 Rho GTPase activating protein 35
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10
ARL4C ADP-ribosylation factor-like 4C
ATP11A ATPase, class VI, type 11A
BMP1 bone morphogenetic protein 1
CAPN10 calpain 10
CBX8 chromobox homolog 8
CDK20 cyclin-dependent kinase 20
CEACAM21 carcinoembryonic antigen-related cell adhesion molecule 21
CES3 carboxylesterase 3
CRYBG3 beta-gamma crystallin domain containing 3
CSHL1 chorionic somatomammotropin hormone-like 1
CYLD cylindromatosis (turban tumor syndrome)
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
DCTN1 dynactin 1
DDX28 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DESI2 desumoylating isopeptidase 2
DGKQ diacylglycerol kinase, theta 110kDa
DPYSL4 dihydropyrimidinase-like 4
DTNA dystrobrevin, alpha
EML1 echinoderm microtubule associated protein like 1
ENPEP glutamyl aminopeptidase (aminopeptidase A)
ERCC2 excision repair cross-complementation group 2
ERCC4 excision repair cross-complementation group 4
ERP44 endoplasmic reticulum protein 44
FBXL7 F-box and leucine-rich repeat protein 7
FDPS farnesyl diphosphate synthase
GPR157 G protein-coupled receptor 157
GPRIN2 G protein regulated inducer of neurite outgrowth 2
GRTP1 growth hormone regulated TBC protein 1
HDAC4 histone deacetylase 4
HIST1H4E histone cluster 1, H4e
HIST1H4F histone cluster 1, H4f
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)
HNRNPA3P1 heterogeneous nuclear ribonucleoprotein A3 pseudogene 1
HOXC4 homeobox C4
HRK harakiri, BCL2 interacting protein
IFT140 intraflagellar transport 140
INE1 inactivation escape 1 (non-protein coding)
IPO8 importin 8
JUN jun proto-oncogene
KAZALD1 Kazal-type serine peptidase inhibitor domain 1
LPCAT4 lysophosphatidylcholine acyltransferase 4
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
LYPD1 LY6/PLAUR domain containing 1
MAPRE2 microtubule-associated protein, RP/EB family, member 2
MBD3 methyl-CpG binding domain protein 3
MEFV Mediterranean fever
MFSD11 major facilitator superfamily domain containing 11
MID2 midline 2
MTSS1L metastasis suppressor 1-like
MYO9B myosin IXB
NEB nebulin
PCDH9 protocadherin 9
PDE4DIP phosphodiesterase 4D interacting protein
PHF20 PHD finger protein 20
PIBF1 progesterone immunomodulatory binding factor 1
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRPH peripherin
PSAT1 phosphoserine aminotransferase 1
RNF122 ring finger protein 122
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1
RPL13 ribosomal protein L13
RPL18 ribosomal protein L18
RPUSD2 RNA pseudouridylate synthase domain containing 2
SAFB2 scaffold attachment factor B2
SGSM3 small G protein signaling modulator 3
SH3BP1 SH3-domain binding protein 1
SIGLEC8 sialic acid binding Ig-like lectin 8
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC23A2 solute carrier family 23 (ascorbic acid transporter), member 2
SLC48A1 solute carrier family 48 (heme transporter), member 1
SMAD3 SMAD family member 3
SMC1A structural maintenance of chromosomes 1A
SMEK1 SMEK homolog 1, suppressor of mek1 (Dictyostelium)
SORBS3 sorbin and SH3 domain containing 3
SP100 SP100 nuclear antigen
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
SRRT serrate, RNA effector molecule
STRN3 striatin, calmodulin binding protein 3
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TAF13 TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa
TEP1 telomerase-associated protein 1
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TLE3 transducin-like enhancer of split 3
TMEM254 transmembrane protein 254
TRIL TLR4 interactor with leucine-rich repeats
YIPF4 Yip1 domain family, member 4
ZC4H2 zinc finger, C4H2 domain containing
ZDHHC17 zinc finger, DHHC-type containing 17
ZNF473 zinc finger protein 473

decreased expression

Symbol Name
ABCA3 ATP-binding cassette, sub-family A (ABC1), member 3
AGBL5 ATP/GTP binding protein-like 5
APPL1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
ARFGAP1 ADP-ribosylation factor GTPase activating protein 1
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ATAD3A ATPase family, AAA domain containing 3A
BCORL1 BCL6 corepressor-like 1
BEX4 brain expressed, X-linked 4
BRIX1 BRX1, biogenesis of ribosomes
BTBD2 BTB (POZ) domain containing 2
BTBD3 BTB (POZ) domain containing 3
C19ORF40 chromosome 19 open reading frame 40
CAPN15 calpain 15
CBR4 carbonyl reductase 4
CCDC6 coiled-coil domain containing 6
CCDC88C coiled-coil domain containing 88C
CCNT1 cyclin T1
CDR2L cerebellar degeneration-related protein 2-like
CHMP6 charged multivesicular body protein 6
CHST12 carbohydrate (chondroitin 4) sulfotransferase 12
CIC capicua transcriptional repressor
CIR1 corepressor interacting with RBPJ, 1
CNKSR1 connector enhancer of kinase suppressor of Ras 1
CSNK1E casein kinase 1, epsilon
CYP20A1 cytochrome P450, family 20, subfamily A, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDX31 DEAD (Asp-Glu-Ala-Asp) box polypeptide 31
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54
DLEU2 deleted in lymphocytic leukemia 2 (non-protein coding)
DNMBP dynamin binding protein
DUSP8 dual specificity phosphatase 8
ELMO3 engulfment and cell motility 3
EPHA2 EPH receptor A2
FAM188A family with sequence similarity 188, member A
FBXL15 F-box and leucine-rich repeat protein 15
FZD4 frizzled class receptor 4
GALNT11 polypeptide N-acetylgalactosaminyltransferase 11
GBF1 golgi brefeldin A resistant guanine nucleotide exchange factor 1
GDAP2 ganglioside induced differentiation associated protein 2
GLB1L2 galactosidase, beta 1-like 2
GNL1 guanine nucleotide binding protein-like 1
GPR87 G protein-coupled receptor 87
GUCY1B2 guanylate cyclase 1, soluble, beta 2 (pseudogene)
HINFP histone H4 transcription factor
ING3 inhibitor of growth family, member 3
KATNBL1 katanin p80 subunit B-like 1
LOC202181 SUMO-interacting motifs containing 1 pseudogene
LRIG2 leucine-rich repeats and immunoglobulin-like domains 2
LRRC42 leucine rich repeat containing 42
MAP9 microtubule-associated protein 9
MBIP MAP3K12 binding inhibitory protein 1
METTL4 methyltransferase like 4
MON1B MON1 secretory trafficking family member B
MRPL44 mitochondrial ribosomal protein L44
MTCL1 microtubule crosslinking factor 1
NR1H2 nuclear receptor subfamily 1, group H, member 2
OGFRL1 opioid growth factor receptor-like 1
PCSK7 proprotein convertase subtilisin/kexin type 7
PDLIM2 PDZ and LIM domain 2 (mystique)
PIGL phosphatidylinositol glycan anchor biosynthesis, class L
PKD2 polycystic kidney disease 2 (autosomal dominant)
PLCG1 phospholipase C, gamma 1
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
PNPLA6 patatin-like phospholipase domain containing 6
PPAN peter pan homolog (Drosophila)
PYGB phosphorylase, glycogen; brain
RAB33B RAB33B, member RAS oncogene family
RAB5B RAB5B, member RAS oncogene family
RHBDF2 rhomboid 5 homolog 2 (Drosophila)
RNF31 ring finger protein 31
RPL13P5 ribosomal protein L13 pseudogene 5
RRAS related RAS viral (r-ras) oncogene homolog
SALL2 spalt-like transcription factor 2
SAV1 salvador family WW domain containing protein 1
SETD8 SET domain containing (lysine methyltransferase) 8
SMAD7 SMAD family member 7
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SMYD5 SMYD family member 5
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
SYNGR3 synaptogyrin 3
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TBC1D12 TBC1 domain family, member 12
TNRC6B trinucleotide repeat containing 6B
TOPORS topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase
TRAF2 TNF receptor-associated factor 2
TRIM25 tripartite motif containing 25
TTC31 tetratricopeptide repeat domain 31
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2
USP6 ubiquitin specific peptidase 6
VAV1 vav 1 guanine nucleotide exchange factor
VGF VGF nerve growth factor inducible
VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae)
WDR60 WD repeat domain 60
XAB2 XPA binding protein 2
YEATS2 YEATS domain containing 2
ZFHX3 zinc finger homeobox 3
ZFP36 ZFP36 ring finger protein
ZNF165 zinc finger protein 165
ZNF276 zinc finger protein 276