pyrithyldione-3482 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the pyrithyldione-3482 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ABCB9 ATP-binding cassette, sub-family B (MDR/TAP), member 9
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
AOX1 aldehyde oxidase 1
APBA3 amyloid beta (A4) precursor protein-binding, family A, member 3
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12
ARL4C ADP-ribosylation factor-like 4C
ATF7IP activating transcription factor 7 interacting protein
AXIN1 axin 1
BAZ2A bromodomain adjacent to zinc finger domain, 2A
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit
CBX8 chromobox homolog 8
CENPI centromere protein I
CHKB choline kinase beta
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4
CTNS cystinosin, lysosomal cystine transporter
CTSF cathepsin F
DCAF13 DDB1 and CUL4 associated factor 13
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
DGAT1 diacylglycerol O-acyltransferase 1
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila)
DOK4 docking protein 4
DTNA dystrobrevin, alpha
EHMT2 euchromatic histone-lysine N-methyltransferase 2
EXD3 exonuclease 3'-5' domain containing 3
EXO5 exonuclease 5
F2R coagulation factor II (thrombin) receptor
GLS2 glutaminase 2 (liver, mitochondrial)
HIST1H1D histone cluster 1, H1d
HIST1H4E histone cluster 1, H4e
HOXC8 homeobox C8
IDS iduronate 2-sulfatase
IFI6 interferon, alpha-inducible protein 6
INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5
KDM7A lysine (K)-specific demethylase 7A
KIAA0930 KIAA0930
LAMP1 lysosomal-associated membrane protein 1
LPCAT4 lysophosphatidylcholine acyltransferase 4
LUZP1 leucine zipper protein 1
MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3
MARC2 mitochondrial amidoxime reducing component 2
MED18 mediator complex subunit 18
METTL7A methyltransferase like 7A
MKNK2 MAP kinase interacting serine/threonine kinase 2
MMP15 matrix metallopeptidase 15 (membrane-inserted)
MYO1D myosin ID
N4BP1 NEDD4 binding protein 1
NAB2 NGFI-A binding protein 2 (EGR1 binding protein 2)
NAT6 N-acetyltransferase 6 (GCN5-related)
NDUFA5 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5
NF1 neurofibromin 1
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2
PAX5 paired box 5
PBX2 pre-B-cell leukemia homeobox 2
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2
POFUT1 protein O-fucosyltransferase 1
PPIA peptidylprolyl isomerase A (cyclophilin A)
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha
PRMT7 protein arginine methyltransferase 7
PSD4 pleckstrin and Sec7 domain containing 4
PTK6 protein tyrosine kinase 6
PTPN14 protein tyrosine phosphatase, non-receptor type 14
PTPN2 protein tyrosine phosphatase, non-receptor type 2
RECQL5 RecQ protein-like 5
RER1 retention in endoplasmic reticulum sorting receptor 1
RHOQ ras homolog family member Q
RMND5A required for meiotic nuclear division 5 homolog A (S. cerevisiae)
RNF126 ring finger protein 126
RNF31 ring finger protein 31
RTEL1 regulator of telomere elongation helicase 1
S100A2 S100 calcium binding protein A2
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SLC4A8 solute carrier family 4, sodium bicarbonate cotransporter, member 8
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SOX15 SRY (sex determining region Y)-box 15
SRSF11 serine/arginine-rich splicing factor 11
STK24 serine/threonine kinase 24
SUGP2 SURP and G patch domain containing 2
SYNGR1 synaptogyrin 1
TAPBP TAP binding protein (tapasin)
TBL1X transducin (beta)-like 1X-linked
TLE4 transducin-like enhancer of split 4
TMEM120B transmembrane protein 120B
TMEM209 transmembrane protein 209
TNXB tenascin XB
TOP3B topoisomerase (DNA) III beta
TRIO trio Rho guanine nucleotide exchange factor
UNKL unkempt family zinc finger-like
USB1 U6 snRNA biogenesis 1
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2
ZBTB48 zinc finger and BTB domain containing 48
ZHX3 zinc fingers and homeoboxes 3
ZNF202 zinc finger protein 202
ZNF419 zinc finger protein 419
ZNF609 zinc finger protein 609
ZNF639 zinc finger protein 639
ZNF783 zinc finger family member 783

decreased expression

Symbol Name
ABI3BP ABI family, member 3 (NESH) binding protein
ALG12 ALG12, alpha-1,6-mannosyltransferase
AMPD1 adenosine monophosphate deaminase 1
APOD apolipoprotein D
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
C14ORF132 chromosome 14 open reading frame 132
C16ORF45 chromosome 16 open reading frame 45
C5 complement component 5
C5AR2 complement component 5a receptor 2
CASZ1 castor zinc finger 1
CCBL1 cysteine conjugate-beta lyase, cytoplasmic
CCDC130 coiled-coil domain containing 130
CCDC25 coiled-coil domain containing 25
CCDC9 coiled-coil domain containing 9
CDK3 cyclin-dependent kinase 3
CEP85 centrosomal protein 85kDa
CLIP4 CAP-GLY domain containing linker protein family, member 4
CORT cortistatin
CTAGE9 CTAGE family, member 9
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
ELSPBP1 epididymal sperm binding protein 1
EPHA2 EPH receptor A2
EPHX2 epoxide hydrolase 2, cytoplasmic
F3 coagulation factor III (thromboplastin, tissue factor)
FGF23 fibroblast growth factor 23
FKBP5 FK506 binding protein 5
FLJ10038 uncharacterized protein FLJ10038
FMOD fibromodulin
GPATCH2L G patch domain containing 2-like
GPATCH3 G patch domain containing 3
GPR143 G protein-coupled receptor 143
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa
GTPBP3 GTP binding protein 3 (mitochondrial)
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HIST1H2BO histone cluster 1, H2bo
HLA-DMB major histocompatibility complex, class II, DM beta
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IGFBP6 insulin-like growth factor binding protein 6
IL4R interleukin 4 receptor
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3
KIAA0319L KIAA0319-like
KIAA0355 KIAA0355
KLHL28 kelch-like family member 28
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
LOC257152 uncharacterized LOC257152
LPAR4 lysophosphatidic acid receptor 4
LYPLA2P1 lysophospholipase II pseudogene 1
MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2
MAPK10 mitogen-activated protein kinase 10
MAPK3 mitogen-activated protein kinase 3
MBNL3 muscleblind-like splicing regulator 3
MBTD1 mbt domain containing 1
MRPL2 mitochondrial ribosomal protein L2
MYO1E myosin IE
NECAB3 N-terminal EF-hand calcium binding protein 3
NEK11 NIMA-related kinase 11
NPFFR1 neuropeptide FF receptor 1
NPIPB15 nuclear pore complex interacting protein family, member B15
NPIPB3 nuclear pore complex interacting protein family, member B3
PAOX polyamine oxidase (exo-N4-amino)
PDPR pyruvate dehydrogenase phosphatase regulatory subunit
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PMM1 phosphomannomutase 1
PPT2 palmitoyl-protein thioesterase 2
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
RFTN1 raftlin, lipid raft linker 1
RPAP1 RNA polymerase II associated protein 1
RPGR retinitis pigmentosa GTPase regulator
SCN1B sodium channel, voltage gated, type I beta subunit
SCYL2 SCY1-like 2 (S. cerevisiae)
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SH2B3 SH2B adaptor protein 3
SIGLEC15 sialic acid binding Ig-like lectin 15
SIRT6 sirtuin 6
SLC12A6 solute carrier family 12 (potassium/chloride transporter), member 6
SLC22A14 solute carrier family 22, member 14
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
TAOK1 TAO kinase 1
TCTN2 tectonic family member 2
TMC5 transmembrane channel-like 5
TMEM110 transmembrane protein 110
TMEM53 transmembrane protein 53
TSNAXIP1 translin-associated factor X interacting protein 1
UBQLN4 ubiquilin 4
USP27X ubiquitin specific peptidase 27, X-linked
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae)
XAB2 XPA binding protein 2
ZBTB25 zinc finger and BTB domain containing 25
ZKSCAN4 zinc finger with KRAB and SCAN domains 4
ZNF205 zinc finger protein 205
ZNF276 zinc finger protein 276
ZNF747 zinc finger protein 747
ZSCAN26 zinc finger and SCAN domain containing 26