pyrvinium-6339 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the pyrvinium-6339 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ACVR1B activin A receptor, type IB
ADAM29 ADAM metallopeptidase domain 29
AGFG1 ArfGAP with FG repeats 1
AMIGO2 adhesion molecule with Ig-like domain 2
AREG amphiregulin
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
ATP2B2 ATPase, Ca++ transporting, plasma membrane 2
BMP15 bone morphogenetic protein 15
C17ORF53 chromosome 17 open reading frame 53
C22ORF46 chromosome 22 open reading frame 46
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1
CALD1 caldesmon 1
CARS cysteinyl-tRNA synthetase
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDC25C cell division cycle 25C
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLIC5 chloride intracellular channel 5
CLUHP3 clustered mitochondria (cluA/CLU1) homolog pseudogene 3
CR1 complement component (3b/4b) receptor 1 (Knops blood group)
CREB3L1 cAMP responsive element binding protein 3-like 1
CXCL8 chemokine (C-X-C motif) ligand 8
CYTH1 cytohesin 1
DCTN1 dynactin 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAAF1 dynein, axonemal, assembly factor 1
DTX2P1-UPK3BP1-PMS2P11 DTX2P1-UPK3BP1-PMS2P11 readthrough transcribed pseudogene
DUSP1 dual specificity phosphatase 1
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
ENTPD4 ectonucleoside triphosphate diphosphohydrolase 4
ETV5 ets variant 5
FAM129A family with sequence similarity 129, member A
FGFR1 fibroblast growth factor receptor 1
FST follistatin
GARS glycyl-tRNA synthetase
GNG7 guanine nucleotide binding protein (G protein), gamma 7
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HOXC10 homeobox C10
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IL12A interleukin 12A
INHBA inhibin, beta A
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KLHL24 kelch-like family member 24
LARP6 La ribonucleoprotein domain family, member 6
LIMK2 LIM domain kinase 2
LMTK1 lemur tail kinase 1
MAP2K5 mitogen-activated protein kinase kinase 5
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
MXD4 MAX dimerization protein 4
NNMT nicotinamide N-methyltransferase
NOVA2 neuro-oncological ventral antigen 2
NR4A2 nuclear receptor subfamily 4, group A, member 2
NUPR1 nuclear protein, transcriptional regulator, 1
OSBPL10 oxysterol binding protein-like 10
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDCD2 programmed cell death 2
PDE4D phosphodiesterase 4D, cAMP-specific
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPARD peroxisome proliferator-activated receptor delta
PSPH phosphoserine phosphatase
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
S100P S100 calcium binding protein P
SBNO2 strawberry notch homolog 2 (Drosophila)
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
SETD8 SET domain containing (lysine methyltransferase) 8
SH3PXD2A SH3 and PX domains 2A
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC38A2 solute carrier family 38, member 2
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SLMO1 slowmo homolog 1 (Drosophila)
SPTLC1 serine palmitoyltransferase, long chain base subunit 1
STC2 stanniocalcin 2
TGFB2 transforming growth factor, beta 2
THBD thrombomodulin
TRIB3 tribbles pseudokinase 3
UBOX5 U-box domain containing 5
USB1 U6 snRNA biogenesis 1
VAC14 Vac14 homolog (S. cerevisiae)
VARS valyl-tRNA synthetase
XBP1 X-box binding protein 1
ZMYM4 zinc finger, MYM-type 4
ZNF419 zinc finger protein 419
ZNF44 zinc finger protein 44
ZNF821 zinc finger protein 821

decreased expression

Symbol Name
ADAT1 adenosine deaminase, tRNA-specific 1
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
B3GNT1
BAHD1 bromo adjacent homology domain containing 1
BTBD2 BTB (POZ) domain containing 2
C1GALT1C1 C1GALT1-specific chaperone 1
C5 complement component 5
CCDC106 coiled-coil domain containing 106
CCNE1 cyclin E1
CCRL2 chemokine (C-C motif) receptor-like 2
CDH3 cadherin 3, type 1, P-cadherin (placental)
CEP112 centrosomal protein 112kDa
CEP131 centrosomal protein 131kDa
CHCHD7 coiled-coil-helix-coiled-coil-helix domain containing 7
CINP cyclin-dependent kinase 2 interacting protein
DDX31 DEAD (Asp-Glu-Ala-Asp) box polypeptide 31
DIXDC1 DIX domain containing 1
DOCK1 dedicator of cytokinesis 1
DPY19L2P2 DPY19L2 pseudogene 2
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
EPHB6 EPH receptor B6
ERAL1 Era-like 12S mitochondrial rRNA chaperone 1
EXOC5 exocyst complex component 5
FCGRT Fc fragment of IgG, receptor, transporter, alpha
GLDC glycine dehydrogenase (decarboxylating)
GRAMD4 GRAM domain containing 4
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HOXC8 homeobox C8
HSPA2 heat shock 70kDa protein 2
KDM5C lysine (K)-specific demethylase 5C
KIFC1 kinesin family member C1
KLK6 kallikrein-related peptidase 6
KRT75 keratin 75, type II
LIMS2 LIM and senescent cell antigen-like domains 2
LMNB1 lamin B1
LOC100272216 uncharacterized LOC100272216
LOC730101 uncharacterized LOC730101
LPCAT1 lysophosphatidylcholine acyltransferase 1
LRP5L low density lipoprotein receptor-related protein 5-like
MICALL2 MICAL-like 2
MOB3B MOB kinase activator 3B
MRPL28 mitochondrial ribosomal protein L28
NBAS neuroblastoma amplified sequence
NDUFAF7 NADH dehydrogenase (ubiquinone) complex I, assembly factor 7
NHEJ1 nonhomologous end-joining factor 1
NMB neuromedin B
NOTCH1 notch 1
NPY1R neuropeptide Y receptor Y1
NRTN neurturin
NXPE3 neurexophilin and PC-esterase domain family, member 3
OCEL1 occludin/ELL domain containing 1
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
OLFML2A olfactomedin-like 2A
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
POLH polymerase (DNA directed), eta
PPAN peter pan homolog (Drosophila)
PPAP2B phosphatidic acid phosphatase type 2B
PPL periplakin
PRAME preferentially expressed antigen in melanoma
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PYCRL pyrroline-5-carboxylate reductase-like
RGL2 ral guanine nucleotide dissociation stimulator-like 2
RRP9 ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast)
RUSC2 RUN and SH3 domain containing 2
S100A9 S100 calcium binding protein A9
SFT2D2 SFT2 domain containing 2
SH3TC2 SH3 domain and tetratricopeptide repeats 2
SIGIRR single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
SLC25A15 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15
SLC43A1 solute carrier family 43 (amino acid system L transporter), member 1
SLC46A3 solute carrier family 46, member 3
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SPAG4 sperm associated antigen 4
SPTLC3 serine palmitoyltransferase, long chain base subunit 3
STAG3 stromal antigen 3
STX1A syntaxin 1A (brain)
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
TEAD3 TEA domain family member 3
TESK2 testis-specific kinase 2
TGFBR3 transforming growth factor, beta receptor III
TMEM8A transmembrane protein 8A
TOR4A torsin family 4, member A
TRMT1L tRNA methyltransferase 1 homolog (S. cerevisiae)-like
TSPAN1 tetraspanin 1
TUBA3C tubulin, alpha 3c
UBTD1 ubiquitin domain containing 1
UNG uracil-DNA glycosylase
WDR13 WD repeat domain 13
WDR46 WD repeat domain 46
XAB2 XPA binding protein 2
ZBTB44 zinc finger and BTB domain containing 44
ZFHX3 zinc finger homeobox 3
ZNF107 zinc finger protein 107
ZNF324 zinc finger protein 324
ZNF571 zinc finger protein 571