quinoline Gene Set

Dataset LINCS L1000 CMAP Chemical Perturbation Consensus Signatures
Category transcriptomics
Type small molecule perturbation
Description The simplest member of the quinoline class of compounds, comprising a benzene ring ortho fused to C-2 and C-3 of a pyridine ring. (Chemical Entities of Biological Interest Ontology, CHEBI_17362)
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Genes

19 genes differentially expressed following the quinoline small molecule perturbation from the LINCS L1000 CMAP Chemical Perturbation Consensus Signatures dataset.

increased expression

Symbol Name Standardized Value
EIF1AY eukaryotic translation initiation factor 1A, Y-linked 3.59784
ZFY zinc finger protein, Y-linked 3.46852
KDM5D lysine (K)-specific demethylase 5D 3.46625
EGFR epidermal growth factor receptor 3.2912
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 3.20071
BCL6 B-cell CLL/lymphoma 6 3.13251
RAB27B RAB27B, member RAS oncogene family 3.06009

decreased expression

Symbol Name Standardized Value
SMC1A structural maintenance of chromosomes 1A -5.1563
PGAM1 phosphoglycerate mutase 1 (brain) -3.92008
E2F2 E2F transcription factor 2 -3.84249
XIC X chromosome inactivation center -3.57447
EIF1AX eukaryotic translation initiation factor 1A, X-linked -3.3549
SMTN smoothelin -3.15004
JCAD junctional cadherin 5 associated -3.12877
KDM6A lysine (K)-specific demethylase 6A -3.11959
RPS5 ribosomal protein S5 -3.11445
TMEM74B transmembrane protein 74B -3.10596
RPL8 ribosomal protein L8 -3.0662
ARSL arylsulfatase L -3.05283