quinpirole-2977 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the quinpirole-2977 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABHD2 abhydrolase domain containing 2
ALDH8A1 aldehyde dehydrogenase 8 family, member A1
ANXA2 annexin A2
AREG amphiregulin
ARL4C ADP-ribosylation factor-like 4C
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
AVIL advillin
AXL AXL receptor tyrosine kinase
BIN1 bridging integrator 1
BMP6 bone morphogenetic protein 6
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCL22 chemokine (C-C motif) ligand 22
CD38 CD38 molecule
CD86 CD86 molecule
CFLAR CASP8 and FADD-like apoptosis regulator
CHN2 chimerin 2
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
COL4A2 collagen, type IV, alpha 2
CREM cAMP responsive element modulator
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa
CTSB cathepsin B
CUX1 cut-like homeobox 1
DNAH17 dynein, axonemal, heavy chain 17
DOCK4 dedicator of cytokinesis 4
DUSP1 dual specificity phosphatase 1
DUSP4 dual specificity phosphatase 4
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1
FADS3 fatty acid desaturase 3
FAM13A family with sequence similarity 13, member A
FLRT2 fibronectin leucine rich transmembrane protein 2
FOXO1 forkhead box O1
FTH1 ferritin, heavy polypeptide 1
FTH1P5 ferritin, heavy polypeptide 1 pseudogene 5
GABARAPL1 GABA(A) receptor-associated protein like 1
GEM GTP binding protein overexpressed in skeletal muscle
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GPR183 G protein-coupled receptor 183
HLA-DRA major histocompatibility complex, class II, DR alpha
HMGB3 high mobility group box 3
HOMER1 homer scaffolding protein 1
HOXA5 homeobox A5
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IFI30 interferon, gamma-inducible protein 30
IL10RA interleukin 10 receptor, alpha
IL11 interleukin 11
IL1RN interleukin 1 receptor antagonist
IL24 interleukin 24
INHBA inhibin, beta A
ISG20 interferon stimulated exonuclease gene 20kDa
KYNU kynureninase
MCTP2 multiple C2 domains, transmembrane 2
MIR22HG MIR22 host gene
MTUS1 microtubule associated tumor suppressor 1
MX2 MX dynamin-like GTPase 2
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NT5E 5'-nucleotidase, ecto (CD73)
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1
PDE4B phosphodiesterase 4B, cAMP-specific
PDE4D phosphodiesterase 4D, cAMP-specific
PDLIM2 PDZ and LIM domain 2 (mystique)
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLSCR1 phospholipid scramblase 1
PPP1R16B protein phosphatase 1, regulatory subunit 16B
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit
PRKCZ protein kinase C, zeta
PRL prolactin
RAB31 RAB31, member RAS oncogene family
RASAL1 RAS protein activator like 1 (GAP1 like)
SAT1 spermidine/spermine N1-acetyltransferase 1
SDC2 syndecan 2
SEC14L1 SEC14-like 1 (S. cerevisiae)
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SH2D2A SH2 domain containing 2A
SH3TC1 SH3 domain and tetratricopeptide repeats 1
SIPA1L1 signal-induced proliferation-associated 1 like 1
SKIL SKI-like proto-oncogene
SLC16A10 solute carrier family 16 (aromatic amino acid transporter), member 10
SLC16A4 solute carrier family 16, member 4
SMOX spermine oxidase
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SPTAN1 spectrin, alpha, non-erythrocytic 1
STAT4 signal transducer and activator of transcription 4
TCF4 transcription factor 4
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
THBS1 thrombospondin 1
TIMP1 TIMP metallopeptidase inhibitor 1
TKTL1 transketolase-like 1
TLR4 toll-like receptor 4
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TYMP thymidine phosphorylase
UNC119 unc-119 homolog (C. elegans)
WIPI1 WD repeat domain, phosphoinositide interacting 1
ZBTB20 zinc finger and BTB domain containing 20
ZBTB38 zinc finger and BTB domain containing 38

decreased expression

Symbol Name
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADGRA3 adhesion G protein-coupled receptor A3
ADRB2 adrenoceptor beta 2, surface
ANKRD55 ankyrin repeat domain 55
APOL6 apolipoprotein L, 6
ARRB1 arrestin, beta 1
BATF3 basic leucine zipper transcription factor, ATF-like 3
C10ORF2 chromosome 10 open reading frame 2
C12ORF29 chromosome 12 open reading frame 29
CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
CARD9 caspase recruitment domain family, member 9
CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3
CCDC86 coiled-coil domain containing 86
CCL2 chemokine (C-C motif) ligand 2
CCL4 chemokine (C-C motif) ligand 4
CCNA1 cyclin A1
CD69 CD69 molecule
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHST12 carbohydrate (chondroitin 4) sulfotransferase 12
CLTCL1 clathrin, heavy chain-like 1
COA7 cytochrome c oxidase assembly factor 7 (putative)
CTSG cathepsin G
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
DKC1 dyskeratosis congenita 1, dyskerin
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
DPY19L2P2 DPY19L2 pseudogene 2
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ENAH enabled homolog (Drosophila)
ERI3 ERI1 exoribonuclease family member 3
EXOSC5 exosome component 5
FAR2 fatty acyl CoA reductase 2
FARSA phenylalanyl-tRNA synthetase, alpha subunit
FLT3 fms-related tyrosine kinase 3
GPD1L glycerol-3-phosphate dehydrogenase 1-like
HCAR3 hydroxycarboxylic acid receptor 3
HOPX HOP homeobox
IFRD2 interferon-related developmental regulator 2
IMPDH1 IMP (inosine 5'-monophosphate) dehydrogenase 1
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
KAT2A K(lysine) acetyltransferase 2A
KBTBD11 kelch repeat and BTB (POZ) domain containing 11
KCNA3 potassium channel, voltage gated shaker related subfamily A, member 3
KIAA0020 KIAA0020
KIF21B kinesin family member 21B
LRP3 low density lipoprotein receptor-related protein 3
MAK16 MAK16 homolog (S. cerevisiae)
MAPK12 mitogen-activated protein kinase 12
METTL1 methyltransferase like 1
MMACHC methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria
MOCOS molybdenum cofactor sulfurase
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
MRPL12 mitochondrial ribosomal protein L12
MRTO4 mRNA turnover 4 homolog (S. cerevisiae)
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAT10 N-acetyltransferase 10 (GCN5-related)
NDUFAF4 NADH dehydrogenase (ubiquinone) complex I, assembly factor 4
NIP7 NIP7, nucleolar pre-rRNA processing protein
NOC3L nucleolar complex associated 3 homolog (S. cerevisiae)
NOL6 nucleolar protein 6 (RNA-associated)
NTHL1 nth endonuclease III-like 1 (E. coli)
PES1 pescadillo ribosomal biogenesis factor 1
PFAS phosphoribosylformylglycinamidine synthase
PLXND1 plexin D1
POLR1C polymerase (RNA) I polypeptide C, 30kDa
PPAN peter pan homolog (Drosophila)
PRDM13 PR domain containing 13
PRTN3 proteinase 3
PSAT1 phosphoserine aminotransferase 1
PSTPIP2 proline-serine-threonine phosphatase interacting protein 2
PUS1 pseudouridylate synthase 1
PUS7 pseudouridylate synthase 7 (putative)
PWP2 PWP2 periodic tryptophan protein homolog (yeast)
RCL1 RNA terminal phosphate cyclase-like 1
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RPIA ribose 5-phosphate isomerase A
RPP40 ribonuclease P/MRP 40kDa subunit
RRP1 ribosomal RNA processing 1
RRP15 ribosomal RNA processing 15 homolog (S. cerevisiae)
RRP7A ribosomal RNA processing 7 homolog A (S. cerevisiae)
RRP9 ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RUVBL1 RuvB-like AAA ATPase 1
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLC39A4 solute carrier family 39 (zinc transporter), member 4
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
TERT telomerase reverse transcriptase
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TNF tumor necrosis factor
TRHDE thyrotropin-releasing hormone degrading enzyme
TTLL12 tubulin tyrosine ligase-like family member 12
UBIAD1 UbiA prenyltransferase domain containing 1
URB2 URB2 ribosome biogenesis 2 homolog (S. cerevisiae)
WDR12 WD repeat domain 12
WDR3 WD repeat domain 3
WDR43 WD repeat domain 43
WT1 Wilms tumor 1