r2tp complex Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description A highly conserved protein complex comprised of two ATP-dependent DNA helicases (Rvb1p and Rvb2p in yeast, Pontin52 and Reptin52 in humans), Pih1p in yeast or PIH1D1 in humans, and Tah1 in yeast or RPAP3 in humans. The complex associates with Hsp90 and is thought to have a role in assembly of large protein or protein/nucleic acid complexes. In this role it is involved in multiple processes such as box C/D snoRNP biogenesis, phosphatidylinositol-3 kinase-related protein kinase (PIKK) signaling, RNA polymerase II assembly, and others. (Gene Ontology, GO_0097255)
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Genes

27 proteins co-occuring with the r2tp complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
PIH1D1 PIH1 domain containing 1 2.85375
RUVBL2 RuvB-like AAA ATPase 2 2.32721
RPAP3 RNA polymerase II associated protein 3 2.29239
ZNHIT3 zinc finger, HIT-type containing 3 1.77796
PDRG1 p53 and DNA-damage regulated 1 1.67629
RUVBL1 RuvB-like AAA ATPase 1 1.52202
WDR92 WD repeat domain 92 1.42598
URI1 URI1, prefoldin-like chaperone 1.2809
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 1.20498
TTI1 TELO2 interacting protein 1 1.20292
RTP1 receptor (chemosensory) transporter protein 1 1.15518
SHQ1 SHQ1, H/ACA ribonucleoprotein assembly factor 1.15211
NUFIP1 nuclear fragile X mental retardation protein interacting protein 1 1.13983
POLR2E polymerase (RNA) II (DNA directed) polypeptide E, 25kDa 0.992204
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.972263
POLR2G polymerase (RNA) II (DNA directed) polypeptide G 0.905996
POLR1A polymerase (RNA) I polypeptide A, 194kDa 0.875028
NOP58 NOP58 ribonucleoprotein 0.739614
NOP56 NOP56 ribonucleoprotein 0.727941
BRWD1 bromodomain and WD repeat domain containing 1 0.607818
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.578833
AREG amphiregulin 0.464397
MTOR mechanistic target of rapamycin (serine/threonine kinase) 0.357086
RPTOR regulatory associated protein of MTOR, complex 1 0.329084
BANF1 barrier to autointegration factor 1 0.276671
RICTOR RPTOR independent companion of MTOR, complex 2 0.26239
KAT5 K(lysine) acetyltransferase 5 0.215412