rac1 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)|The protein encoded by this gene is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009] (NCBI Entrez Gene Database, 5879)
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Genes

360 genes co-occuring with the biological term rac1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABI1 abl-interactor 1
ACTA1 actin, alpha 1, skeletal muscle
ACTB actin, beta
ACTG1 actin gamma 1
ACTN1 actinin, alpha 1
ADAM10 ADAM metallopeptidase domain 10
AGER advanced glycosylation end product-specific receptor
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AIF1 allograft inflammatory factor 1
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT3 v-akt murine thymoma viral oncogene homolog 3
ALK anaplastic lymphoma receptor tyrosine kinase
ALS2 amyotrophic lateral sclerosis 2 (juvenile)
ANGPT1 angiopoietin 1
APP amyloid beta (A4) precursor protein
ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
ARF1 ADP-ribosylation factor 1
ARF6 ADP-ribosylation factor 6
ARFIP2 ADP-ribosylation factor interacting protein 2
ARHGAP12 Rho GTPase activating protein 12
ARHGAP15 Rho GTPase activating protein 15
ARHGAP24 Rho GTPase activating protein 24
ARHGAP35 Rho GTPase activating protein 35
ARHGAP44 Rho GTPase activating protein 44
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARHGEF18 Rho/Rac guanine nucleotide exchange factor (GEF) 18
ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7
ARL1 ADP-ribosylation factor-like 1
ARL2BP ADP-ribosylation factor-like 2 binding protein
ATP6V1E1 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1
BAD BCL2-associated agonist of cell death
BCAR1 breast cancer anti-estrogen resistance 1
BCL2 B-cell CLL/lymphoma 2
BCL6 B-cell CLL/lymphoma 6
BECN1 beclin 1, autophagy related
BIRC3 baculoviral IAP repeat containing 3
BIRC5 baculoviral IAP repeat containing 5
BRAF B-Raf proto-oncogene, serine/threonine kinase
BZW1 basic leucine zipper and W2 domains 1
CAV1 caveolin 1, caveolae protein, 22kDa
CCDC125 coiled-coil domain containing 125
CCND1 cyclin D1
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CD151 CD151 molecule (Raph blood group)
CD40LG CD40 ligand
CD44 CD44 molecule (Indian blood group)
CD81 CD81 molecule
CD82 CD82 molecule
CDC42 cell division cycle 42
CDC42EP2 CDC42 effector protein (Rho GTPase binding) 2
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDH13 cadherin 13
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CFL1 cofilin 1 (non-muscle)
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CGNL1 cingulin-like 1
CHN1 chimerin 1
CHN2 chimerin 2
CHRM3 cholinergic receptor, muscarinic 3
CLEC1B C-type lectin domain family 1, member B
CLIP1 CAP-GLY domain containing linker protein 1
COL1A1 collagen, type I, alpha 1
COL1A2 collagen, type I, alpha 2
CORO1A coronin, actin binding protein, 1A
CORO1C coronin, actin binding protein, 1C
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like
CSF3 colony stimulating factor 3 (granulocyte)
CTGF connective tissue growth factor
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTNND2 catenin (cadherin-associated protein), delta 2
CTTN cortactin
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR2 chemokine (C-X-C motif) receptor 2
CXCR4 chemokine (C-X-C motif) receptor 4
CYBB cytochrome b-245, beta polypeptide
CYCS cytochrome c, somatic
CYFIP1 cytoplasmic FMR1 interacting protein 1
CYFIP2 cytoplasmic FMR1 interacting protein 2
CYLD cylindromatosis (turban tumor syndrome)
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
DCC DCC netrin 1 receptor
DEF6 differentially expressed in FDCP 6 homolog (mouse)
DGKZ diacylglycerol kinase, zeta
DIAPH1 diaphanous-related formin 1
DNM1 dynamin 1
DNM2 dynamin 2
DOCK1 dedicator of cytokinesis 1
DOCK10 dedicator of cytokinesis 10
DOCK2 dedicator of cytokinesis 2
DOCK3 dedicator of cytokinesis 3
DOCK4 dedicator of cytokinesis 4
DOCK6 dedicator of cytokinesis 6
DSG3 desmoglein 3
DST dystonin
DUSP1 dual specificity phosphatase 1
ECT2 epithelial cell transforming 2
EGF epidermal growth factor
EGFR epidermal growth factor receptor
EHD2 EH-domain containing 2
EIF5A2 eukaryotic translation initiation factor 5A2
ELMO1 engulfment and cell motility 1
ENAH enabled homolog (Drosophila)
EPS8 epidermal growth factor receptor pathway substrate 8
ERBB2 erb-b2 receptor tyrosine kinase 2
ETV6 ets variant 6
EZR ezrin
F2 coagulation factor II (thrombin)
F2R coagulation factor II (thrombin) receptor
FAS Fas cell surface death receptor
FERMT3 fermitin family member 3
FGF2 fibroblast growth factor 2 (basic)
FLNA filamin A, alpha
FMNL1 formin-like 1
FPR1 formyl peptide receptor 1
FRMD7 FERM domain containing 7
FRMPD4 FERM and PDZ domain containing 4
FZD2 frizzled class receptor 2
FZD4 frizzled class receptor 4
FZD5 frizzled class receptor 5
FZD7 frizzled class receptor 7
GDI1 GDP dissociation inhibitor 1
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GIT2 G protein-coupled receptor kinase interacting ArfGAP 2
GJA1 gap junction protein, alpha 1, 43kDa
GLI1 GLI family zinc finger 1
GNAQ guanine nucleotide binding protein (G protein), q polypeptide
GPR55 G protein-coupled receptor 55
GSK3B glycogen synthase kinase 3 beta
GULP1 GULP, engulfment adaptor PTB domain containing 1
HACE1 HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HMGB1 high mobility group box 1
HRAS Harvey rat sarcoma viral oncogene homolog
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
ICAM1 intercellular adhesion molecule 1
ICMT isoprenylcysteine carboxyl methyltransferase
ICOS inducible T-cell co-stimulator
IFNG interferon, gamma
IGF1R insulin-like growth factor 1 receptor
IGF2R insulin-like growth factor 2 receptor
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
IL1B interleukin 1, beta
IL1R1 interleukin 1 receptor, type I
IL2 interleukin 2
ILK integrin-linked kinase
IQGAP1 IQ motif containing GTPase activating protein 1
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
ITGA6 integrin, alpha 6
ITGAV integrin, alpha V
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
ITGB4 integrin, beta 4
ITGB6 integrin, beta 6
JAK2 Janus kinase 2
JUN jun proto-oncogene
KDR kinase insert domain receptor
KLF6 Kruppel-like factor 6
KMT2A lysine (K)-specific methyltransferase 2A
KNG1 kininogen 1
KRAS Kirsten rat sarcoma viral oncogene homolog
LAMC2 laminin, gamma 2
LIMS1 LIM and senescent cell antigen-like domains 1
LRRK2 leucine-rich repeat kinase 2
MACC1 metastasis associated in colon cancer 1
MAP3K11 mitogen-activated protein kinase kinase kinase 11
MAPK1 mitogen-activated protein kinase 1
MAPK11 mitogen-activated protein kinase 11
MAPK3 mitogen-activated protein kinase 3
MAPK7 mitogen-activated protein kinase 7
MAPK8 mitogen-activated protein kinase 8
MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3
MARCKS myristoylated alanine-rich protein kinase C substrate
MARK2 MAP/microtubule affinity-regulating kinase 2
MCF2L MCF.2 cell line derived transforming sequence-like
MET MET proto-oncogene, receptor tyrosine kinase
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MIR142 microRNA 142
MIR146A microRNA 146a
MIR200B microRNA 200b
MIR320A microRNA 320a
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
MMP1 matrix metallopeptidase 1
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MMP2 matrix metallopeptidase 2
MMP9 matrix metallopeptidase 9
MTMR3 myotubularin related protein 3
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MTSS1L metastasis suppressor 1-like
MVK mevalonate kinase
MYADM myeloid-associated differentiation marker
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYD88 myeloid differentiation primary response 88
NAV1 neuron navigator 1
NCF1 neutrophil cytosolic factor 1
NCF2 neutrophil cytosolic factor 2
NCK1 NCK adaptor protein 1
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NEK3 NIMA-related kinase 3
NET1 neuroepithelial cell transforming 1
NEU3 sialidase 3 (membrane sialidase)
NEWENTRY Record to support submission of GeneRIFs for a gene not in Gene (human; man).
NFE2L2 nuclear factor, erythroid 2-like 2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NGEF neuronal guanine nucleotide exchange factor
NGF nerve growth factor (beta polypeptide)
NLRP3 NLR family, pyrin domain containing 3
NOD1 nucleotide-binding oligomerization domain containing 1
NOS3 nitric oxide synthase 3 (endothelial cell)
NOV nephroblastoma overexpressed
NOX1 NADPH oxidase 1
NOX3 NADPH oxidase 3
NOX5 NADPH oxidase, EF-hand calcium binding domain 5
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NR1H2 nuclear receptor subfamily 1, group H, member 2
NR1H3 nuclear receptor subfamily 1, group H, member 3
NRG1 neuregulin 1
NXPH1 neurexophilin 1
OCM oncomodulin
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1
PACSIN2 protein kinase C and casein kinase substrate in neurons 2
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PAK2 p21 protein (Cdc42/Rac)-activated kinase 2
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4
PARVB parvin, beta
PDE2A phosphodiesterase 2A, cGMP-stimulated
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PEA15 phosphoprotein enriched in astrocytes 15
PHF8 PHD finger protein 8
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIKFYVE phosphoinositide kinase, FYVE finger containing
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PKN1 protein kinase N1
PLA2G4B phospholipase A2, group IVB (cytosolic)
PLAU plasminogen activator, urokinase
PLAUR plasminogen activator, urokinase receptor
PLCB2 phospholipase C, beta 2
PLCD1 phospholipase C, delta 1
PLCG1 phospholipase C, gamma 1
PLD1 phospholipase D1, phosphatidylcholine-specific
PLD2 phospholipase D2
PLEKHG4 pleckstrin homology domain containing, family G (with RhoGef domain) member 4
PLXNB1 plexin B1
PLXNB3 plexin B3
PODXL podocalyxin-like
PPARG peroxisome proliferator-activated receptor gamma
PPP5C protein phosphatase 5, catalytic subunit
PRKCE protein kinase C, epsilon
PRKCI protein kinase C, iota
PRKCZ protein kinase C, zeta
PRKD1 protein kinase D1
PRKG1 protein kinase, cGMP-dependent, type I
PRPS1L1 phosphoribosyl pyrophosphate synthetase 1-like 1
PSD pleckstrin and Sec7 domain containing
PTEN phosphatase and tensin homolog
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTK2 protein tyrosine kinase 2
PTK2B protein tyrosine kinase 2 beta
PTK6 protein tyrosine kinase 6
PTPRA protein tyrosine phosphatase, receptor type, A
PVRL4 poliovirus receptor-related 4
PXN paxillin
PYGM phosphorylase, glycogen, muscle
RAB7A RAB7A, member RAS oncogene family
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
RACGAP1 Rac GTPase activating protein 1
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RAP1A RAP1A, member of RAS oncogene family
RAP1B RAP1B, member of RAS oncogene family
RAP1GDS1 RAP1, GTP-GDP dissociation stimulator 1
RAPGEF3 Rap guanine nucleotide exchange factor (GEF) 3
RCC2 regulator of chromosome condensation 2
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS3 regulator of G-protein signaling 3
RHOA ras homolog family member A
RHOD ras homolog family member D
RHOF ras homolog family member F (in filopodia)
RHOG ras homolog family member G
RND1 Rho family GTPase 1
ROCK1 Rho-associated, coiled-coil containing protein kinase 1
RPA3 replication protein A3, 14kDa
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
RUNX1 runt-related transcription factor 1
S100A10 S100 calcium binding protein A10
S1PR1 sphingosine-1-phosphate receptor 1
S1PR3 sphingosine-1-phosphate receptor 3
SEMA3F sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFRP1 secreted frizzled-related protein 1
SH3RF3 SH3 domain containing ring finger 3
SH3YL1 SH3 and SYLF domain containing 1
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SHH sonic hedgehog
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SLIT2 slit homolog 2 (Drosophila)
SMAD2 SMAD family member 2
SMAD3 SMAD family member 3
SMO smoothened, frizzled class receptor
SNTA1 syntrophin, alpha 1
SNX2 sorting nexin 2
SNX5 sorting nexin 5
SOD1 superoxide dismutase 1, soluble
SOS1 son of sevenless homolog 1 (Drosophila)
SOX9 SRY (sex determining region Y)-box 9
SPATA13 spermatogenesis associated 13
SPRY2 sprouty homolog 2 (Drosophila)
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1
SRGAP3 SLIT-ROBO Rho GTPase activating protein 3
STAP2 signal transducing adaptor family member 2
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
SYNJ2 synaptojanin 2
TACSTD2 tumor-associated calcium signal transducer 2
TEK TEK tyrosine kinase, endothelial
TGFB1 transforming growth factor, beta 1
THBS2 thrombospondin 2
TIAM1 T-cell lymphoma invasion and metastasis 1
TIAM2 T-cell lymphoma invasion and metastasis 2
TIMP2 TIMP metallopeptidase inhibitor 2
TIPE2 TNF alpha induced protein 8 like 2
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein
TLR2 toll-like receptor 2
TLR4 toll-like receptor 4
TNF tumor necrosis factor
TNFRSF19 tumor necrosis factor receptor superfamily, member 19
TNFSF12 tumor necrosis factor (ligand) superfamily, member 12
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TRIO trio Rho guanine nucleotide exchange factor
TSC2 tuberous sclerosis 2
TYK2 tyrosine kinase 2
USP6 ubiquitin specific peptidase 6
VASP vasodilator-stimulated phosphoprotein
VAV1 vav 1 guanine nucleotide exchange factor
VAV2 vav 2 guanine nucleotide exchange factor
VEGFA vascular endothelial growth factor A
WASF1 WAS protein family, member 1
WIF1 WNT inhibitory factor 1
WNK2 WNK lysine deficient protein kinase 2
WNT5A wingless-type MMTV integration site family, member 5A
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
ZYX zyxin