rac2 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)|This gene encodes a member of the Ras superfamily of small guanosine triphosphate (GTP)-metabolizing proteins. The encoded protein localizes to the plasma membrane, where it regulates diverse processes, such as secretion, phagocytosis, and cell polarization. Activity of this protein is also involved in the generation of reactive oxygen species. Mutations in this gene are associated with neutrophil immunodeficiency syndrome. There is a pseudogene for this gene on chromosome 6. [provided by RefSeq, Jul 2013] (NCBI Entrez Gene Database, 5880)
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Genes

27 genes co-occuring with the biological term rac2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
CDC42 cell division cycle 42
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR4 chemokine (C-X-C motif) receptor 4
CYBB cytochrome b-245, beta polypeptide
DOCK1 dedicator of cytokinesis 1
DOCK2 dedicator of cytokinesis 2
DOCK9 dedicator of cytokinesis 9
ELMO1 engulfment and cell motility 1
GNAQ guanine nucleotide binding protein (G protein), q polypeptide
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1
GNB2L1 guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
GNG2 guanine nucleotide binding protein (G protein), gamma 2
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
NCF1 neutrophil cytosolic factor 1
NCF2 neutrophil cytosolic factor 2
NOS2 nitric oxide synthase 2, inducible
PLCB2 phospholipase C, beta 2
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PLD2 phospholipase D2
PREX1 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RHOH ras homolog family member H
SRC SRC proto-oncogene, non-receptor tyrosine kinase