rad50 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description RAD50 homolog (S. cerevisiae)|The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Rad50, a protein involved in DNA double-strand break repair. This protein forms a complex with MRE11 and NBS1. The protein complex binds to DNA and displays numerous enzymatic activities that are required for nonhomologous joining of DNA ends. This protein, cooperating with its partners, is important for DNA double-strand break repair, cell cycle checkpoint activation, telomere maintenance, and meiotic recombination. Knockout studies of the mouse homolog suggest this gene is essential for cell growth and viability. Mutations in this gene are the cause of Nijmegen breakage syndrome-like disorder.[provided by RefSeq, Apr 2010] (NCBI Entrez Gene Database, 10111)
Similar Terms
Downloads & Tools

Genes

21 genes co-occuring with the biological term rad50 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ATM ATM serine/threonine kinase
BRCA1 breast cancer 1, early onset
BTF3 basic transcription factor 3
CARD9 caspase recruitment domain family, member 9
CCL5 chemokine (C-C motif) ligand 5
CHEK2 checkpoint kinase 2
FANCD2 Fanconi anemia, complementation group D2
H2AFX H2A histone family, member X
IL4R interleukin 4 receptor
ING1 inhibitor of growth family, member 1
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
NBN nibrin
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PTPRE protein tyrosine phosphatase, receptor type, E
RAD17 RAD17 homolog (S. pombe)
RAD50 RAD50 homolog (S. cerevisiae)
RBBP8 retinoblastoma binding protein 8
RPA1 replication protein A1, 70kDa
SMC1A structural maintenance of chromosomes 1A
TBXA2R thromboxane A2 receptor
TP53 tumor protein p53