rad51 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description RAD51 recombinase|The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and strand transfer of DNA. This protein is also found to interact with BRCA1 and BRCA2, which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both the intracellular localization and DNA-binding ability of this protein. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009] (NCBI Entrez Gene Database, 5888)
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Genes

84 genes co-occuring with the biological term rad51 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
AGO2 argonaute RISC catalytic component 2
AKT1 v-akt murine thymoma viral oncogene homolog 1
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
ARL11 ADP-ribosylation factor-like 11
ATM ATM serine/threonine kinase
ATMIN ATM interactor
ATR ATR serine/threonine kinase
ATRX alpha thalassemia/mental retardation syndrome X-linked
AURKA aurora kinase A
BARD1 BRCA1 associated RING domain 1
BCCIP BRCA2 and CDKN1A interacting protein
BLM Bloom syndrome, RecQ helicase-like
BRCA1 breast cancer 1, early onset
BRCA2 breast cancer 2, early onset
BRIP1 BRCA1 interacting protein C-terminal helicase 1
CASP3 caspase 3, apoptosis-related cysteine peptidase
CHEK1 checkpoint kinase 1
CHEK2 checkpoint kinase 2
CREBBP CREB binding protein
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
DCLRE1C DNA cross-link repair 1C
DMC1 DNA meiotic recombinase 1
DUSP12 dual specificity phosphatase 12
E2F4 E2F transcription factor 4, p107/p130-binding
EP300 E1A binding protein p300
ERCC2 excision repair cross-complementation group 2
ESR2 estrogen receptor 2 (ER beta)
FANCD2 Fanconi anemia, complementation group D2
FBXO18 F-box protein, helicase, 18
FEN1 flap structure-specific endonuclease 1
FIGNL1 fidgetin-like 1
GSTA1 glutathione S-transferase alpha 1
GSTM1 glutathione S-transferase mu 1
GSTT1 glutathione S-transferase theta 1
H2AFX H2A histone family, member X
HELQ helicase, POLQ-like
IGF1R insulin-like growth factor 1 receptor
IRS1 insulin receptor substrate 1
MAPK1 mitogen-activated protein kinase 1
MCM8 minichromosome maintenance complex component 8
MCM9 minichromosome maintenance complex component 9
MDC1 mediator of DNA-damage checkpoint 1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MIR107 microRNA 107
MIR155 microRNA 155
MIR22 microRNA 22
MIR96 microRNA 96
MSH2 mutS homolog 2
NOLC1 nucleolar and coiled-body phosphoprotein 1
NQO1 NAD(P)H dehydrogenase, quinone 1
OGG1 8-oxoguanine DNA glycosylase
PALB2 partner and localizer of BRCA2
PARP1 poly (ADP-ribose) polymerase 1
PAXIP1 PAX interacting (with transcription-activation domain) protein 1
RAD18 RAD18 E3 ubiquitin protein ligase
RAD51 RAD51 recombinase
RAD51AP1 RAD51 associated protein 1
RAD51AP2 RAD51 associated protein 2
RAD51B RAD51 paralog B
RAD51C RAD51 paralog C
RAD51D RAD51 paralog D
RAD52 RAD52 homolog (S. cerevisiae)
RAD54L RAD54-like (S. cerevisiae)
RECQL5 RecQ protein-like 5
REV1 REV1, polymerase (DNA directed)
RNF8 ring finger protein 8, E3 ubiquitin protein ligase
RPA1 replication protein A1, 70kDa
RPA2 replication protein A2, 32kDa
RUVBL1 RuvB-like AAA ATPase 1
RUVBL2 RuvB-like AAA ATPase 2
SPIDR scaffolding protein involved in DNA repair
SYCP3 synaptonemal complex protein 3
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TGFB1 transforming growth factor, beta 1
TOP1 topoisomerase (DNA) I
TP53 tumor protein p53
TP53BP1 tumor protein p53 binding protein 1
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6
YARS tyrosyl-tRNA synthetase
YY1 YY1 transcription factor