raf-1 Gene Set

Dataset Phosphosite Textmining Biological Term Annotations
Category structural or functional annotations
Type biological term
Description Raf-1 proto-oncogene, serine/threonine kinase|This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 5894)
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Genes

56 proteins co-occuring with the biological term raf-1 in abstracts of publications describing phosphosites from the Phosphosite Textmining Biological Term Annotations dataset.

Symbol Name
AKT1 v-akt murine thymoma viral oncogene homolog 1
ARAF A-Raf proto-oncogene, serine/threonine kinase
ATM ATM serine/threonine kinase
BAD BCL2-associated agonist of cell death
BRAF B-Raf proto-oncogene, serine/threonine kinase
CDK10 cyclin-dependent kinase 10
CDK2 cyclin-dependent kinase 2
CREB1 cAMP responsive element binding protein 1
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
EGFR epidermal growth factor receptor
ELK1 ELK1, member of ETS oncogene family
GSK3A glycogen synthase kinase 3 alpha
GSK3B glycogen synthase kinase 3 beta
IFI16 interferon, gamma-inducible protein 16
JUN jun proto-oncogene
KRAS Kirsten rat sarcoma viral oncogene homolog
KSR1 kinase suppressor of ras 1
L1CAM L1 cell adhesion molecule
MAP2K1 mitogen-activated protein kinase kinase 1
MAP2K2 mitogen-activated protein kinase kinase 2
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PEBP1 phosphatidylethanolamine binding protein 1
PHB prohibitin
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLD1 phospholipase D1, phosphatidylcholine-specific
PPP1R12A protein phosphatase 1, regulatory subunit 12A
PRKCD protein kinase C, delta
PRKCZ protein kinase C, zeta
PTEN phosphatase and tensin homolog
PTK2 protein tyrosine kinase 2
PTPN3 protein tyrosine phosphatase, non-receptor type 3
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RAP1A RAP1A, member of RAS oncogene family
RB1 retinoblastoma 1
RGS19 regulator of G-protein signaling 19
RMDN3 regulator of microtubule dynamics 3
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STK3 serine/threonine kinase 3
STMN1 stathmin 1
TP53 tumor protein p53
TTK TTK protein kinase
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta